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Quality of Life Research
Published in: Quality of Life Research 2/2022

Open Access 01-02-2022 | Central Nervous System Trauma

Development of prognostic models for Health-Related Quality of Life following traumatic brain injury

Authors: Isabel R. A. Retel Helmrich, David van Klaveren, Simone A. Dijkland, Hester F. Lingsma, Suzanne Polinder, Lindsay Wilson, Nicole von Steinbuechel, Joukje van der Naalt, Andrew I. R. Maas, Ewout W. Steyerberg, CENTER-TBI Collaborators

Published in: Quality of Life Research | Issue 2/2022

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Abstract

Background

Traumatic brain injury (TBI) is a leading cause of impairments affecting Health-Related Quality of Life (HRQoL). We aimed to identify predictors of and develop prognostic models for HRQoL following TBI.

Methods

We used data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Core study, including patients with a clinical diagnosis of TBI and an indication for computed tomography presenting within 24 h of injury. The primary outcome measures were the SF-36v2 physical (PCS) and mental (MCS) health component summary scores and the Quality of Life after Traumatic Brain Injury (QOLIBRI) total score 6 months post injury. We considered 16 patient and injury characteristics in linear regression analyses. Model performance was expressed as proportion of variance explained (R2) and corrected for optimism with bootstrap procedures.

Results

2666 Adult patients completed the HRQoL questionnaires. Most were mild TBI patients (74%). The strongest predictors for PCS were Glasgow Coma Scale, major extracranial injury, and pre-injury health status, while MCS and QOLIBRI were mainly related to pre-injury mental health problems, level of education, and type of employment. R2 of the full models was 19% for PCS, 9% for MCS, and 13% for the QOLIBRI. In a subset of patients following predominantly mild TBI (N = 436), including 2 week HRQoL assessment improved model performance substantially (R2 PCS 15% to 37%, MCS 12% to 36%, and QOLIBRI 10% to 48%).

Conclusion

Medical and injury-related characteristics are of greatest importance for the prediction of PCS, whereas patient-related characteristics are more important for the prediction of MCS and the QOLIBRI following TBI.
Appendix
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Metadata
Title
Development of prognostic models for Health-Related Quality of Life following traumatic brain injury
Authors
Isabel R. A. Retel Helmrich
David van Klaveren
Simone A. Dijkland
Hester F. Lingsma
Suzanne Polinder
Lindsay Wilson
Nicole von Steinbuechel
Joukje van der Naalt
Andrew I. R. Maas
Ewout W. Steyerberg
CENTER-TBI Collaborators
Publication date
01-02-2022
Publisher
Springer International Publishing
Published in
Quality of Life Research / Issue 2/2022
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-021-02932-z

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