Top

Quality of Life Research

Published in:

Open Access 01-12-2020 | Psycho-oncology

Quality of life and distress assessed with self and external assessment screening tools in patients with hematologic malignancies attending treatment in an acute hospital

Authors: Bianca Senf, Kirsten Grabowski, Natascha Spielmann, Jens Fettel

Published in: Quality of Life Research | Issue 12/2020

Abstract

Purpose

In this study, we examined distress levels and quality of life (QoL) of patients with hematologic malignancies under treatment in an acute setting. We used external- and self-assessment instruments for distress. Additionally, we investigated the relation between distress and QoL as well as whether highly distressed patients differed from less distressed patients concerning their QoL.

Methods

A cross-sectional study with patients of the Medical Clinic II of the University Hospital Frankfurt was conducted. One hundred and nine patients were assessed with an expert rating scale and completed self-report questionnaires. Data were exploratively analyzed and group comparisons between patients who scored above the cut-off of the respective screening instruments and those who did not were conducted.

Results

Patients with hematologic malignancies experience high levels of distress and low QoL. Especially, role and social functioning are affected. Patients suffer most from fatigue, appetite loss, and insomnia. Using established cut-offs, all screening instruments were able to differentiate between patients regarding distress and QoL. Patients scoring above the cut-off were significantly more distressed and had a lower QoL. There was a medium-to-strong correlation between distress and QoL indicators.

Conclusion

Cancer-specific screening instruments seem to be able to identify treatment needs more specifically. They also allowed a better differentiation concerning QoL. The close link between distress and QoL needs to be recognized to enable a holistic approach to treatment and thereby optimize the quality of treatment.

Robert Koch-Institut. (2017). Krebs in Deutschland für 2013/2014.

Manitta, V., Zordan, R., Cole-Sinclair, M., Nandurkar, H., & Philip, J. (2011). The symptom burden of patients with hematological malignancy: A cross-sectional observational study. Journal of Pain and Symptom Management, 42(3), 432–442. https://doi.org/10.1016/j.jpainsymman.2010.12.008.CrossRefPubMed

Bailer, H., & Grulke, N. (2016). Hämatologisch-onkologische Systemerkrankungen unter besonderer Berücksichtigung der Stammzelltransplantation. In A. Mehnert & U. Koch (Eds.), Handbuch Psychoonkologie (1st ed., pp. 180–184). Göttingen: Hogrefe.

Riba, M. B., Donovan, K. A., Andersen, B., Braun, I., Breitbart, W. S., Brewer, B. W., et al. (2019). Distress Management, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network: JNCCN, 17(10), 1229–1249. https://doi.org/10.6004/jnccn.2019.0048.CrossRefPubMed

Sellick, S. M., & Edwardson, A. D. (2007). Screening new cancer patients for psychological distress using the hospital anxiety and depression scale. Psycho-oncology, 16(6), 534–542. https://doi.org/10.1002/pon.1085.CrossRefPubMed

Linden, W., Vodermaier, A., Mackenzie, R., & Greig, D. (2012). Anxiety and depression after cancer diagnosis. Prevalence rates by cancer type, gender, and age. Journal of Affective Disorders, 141(2–3), 343–351. https://doi.org/10.1016/j.jad.2012.03.025.CrossRefPubMed

Batty, G. D., Russ, T. C., Stamatakis, E., & Kivimäki, M. (2017). Psychological distress in relation to site specific cancer mortality. Pooling of unpublished data from 16 prospective cohort studies. BMJ, 356, j108. https://doi.org/10.1136/bmj.j108.CrossRefPubMedPubMedCentral

Montgomery, C., Pocock, M., Titley, K., & Lloyd, K. (2003). Predicting psychological distress in patients with leukaemia and lymphoma. Journal of Psychosomatic Research, 54(4), 289–292. https://doi.org/10.1016/S0022-3999(02)00396-3.CrossRefPubMed

Clinton-McHarg, T., Carey, M., Sanson-Fisher, R., Tzelepis, F., Bryant, J., & Williamson, A. (2014). Anxiety and depression among haematological cancer patients attending treatment centres. Prevalence and predictors. Journal of Affective Disorders, 165, 176–181. https://doi.org/10.1016/j.jad.2014.04.072.CrossRefPubMed

10.

Abuelgasim, K. A., Ahmed, G. Y., Alqahtani, J. A., Alayed, A. M., Alaskar, A. S., & Malik, M. A. (2016). Depression and anxiety in patients with hematological malignancies, prevalence, and associated factors. Saudi Medical Journal, 37(8), 877–881. https://doi.org/10.15537/smj.2016.8.14597.CrossRefPubMedPubMedCentral

11.

Gheihman, G., Zimmermann, C., Deckert, A., Fitzgerald, P., Mischitelle, A., Rydall, A., et al. (2016). Depression and hopelessness in patients with acute leukemia. The psychological impact of an acute and life-threatening disorder. Psycho-oncology, 25(8), 979–989. https://doi.org/10.1002/pon.3940.CrossRefPubMed

12.

Vodermaier, A., Linden, W., Rnic, K., Young, S. N., Ng, A., Ditsch, N., et al. (2014). Prospective associations of depression with survival. A population-based cohort study in patients with newly diagnosed breast cancer. Breast Cancer Research and Treatment, 143(2), 373–384. https://doi.org/10.1007/s10549-013-2795-4.CrossRefPubMed

13.

Jansen, F., Verdonck-de Leeuw, I. M., Cuijpers, P., Leemans, C. R., Waterboer, T., Pawlita, M., et al. (2018). Depressive symptoms in relation to overall survival in people with head and neck cancer. A longitudinal cohort study. Psycho-oncology, 27(9), 2245–2256. https://doi.org/10.1002/pon.4816.CrossRefPubMedPubMedCentral

14.

Shi, C., Lamba, N., Zheng, L. J., Cote, D., Regestein, Q. R., Liu, C. M., et al. (2018). Depression and survival of glioma patients. A systematic review and meta-analysis. Clinical Neurology and Neurosurgery, 172, 8–19. https://doi.org/10.1016/j.clineuro.2018.06.016.CrossRefPubMed

15.

Allart, P., Soubeyran, P., & Cousson-Gélie, F. (2013). Are psychosocial factors associated with quality of life in patients with haematological cancer? A critical review of the literature. Psycho-oncology, 22(2), 241–249. https://doi.org/10.1002/pon.3026.CrossRefPubMed

16.

Santos, F. R. M., Kozasa, E. H., Chauffaille, M., de Lourdes, L. F., Colleoni, G. W. B., & Leite, J. R. (2006). Psychosocial adaptation and quality of life among Brazilian patients with different hematological malignancies. Journal of Psychosomatic Research, 60(5), 505–511. https://doi.org/10.1016/j.jpsychores.2005.08.017.CrossRefPubMed

17.

Zittoun, R., Achard, S., & Ruszniewski, M. (1999). Assessment of quality of life during intensive chemotherapy or bone marrow transplantation. Psycho-oncology, 8(1), 64–73. https://doi.org/10.1002/(SICI)1099-1611(199901/02)8:1<64:AID-PON337>3.0.CO;2-R.CrossRefPubMed

18.

Broers, S., Kaptein, A. A., Le Cessie, S., Fibbe, W., & Hengeveld, M. W. (2000). Psychological functioning and quality of life following bone marrow transplantation. A 3-year follow-up study. Journal of Psychosomatic Research, 48(1), 11–21.CrossRef

19.

Mehnert, A. (2016). Psychoonkologische Diagnostik in der Onkologie. Anja Mehnert und Uwe Koch (Hg.): Handbuch Psychoonkologie. 1. Auflage. Göttingen: Hogrefe, 216–223.

20.

Herschbach, P., Marten-Mittag, B. (2008). Manual und Interviewleitfaden zur Psychoonkologischen Basisdokumentation. Kurzform (PO-Bado-KF). Unter Mitarbeit von Peter Herschbach, Monika Keller, Gabriele Blettner, Erhard Schneider, Gerhard Strittmatter, Andrea Schumacher et al. Hg. v. Arbeitsgruppe PO-Bado München. Arbeitsgruppe PO-Bado München. München. Online verfügbar unter https://www.po-bado.med.tu-muenchen.de/pdf/Kurzform/PO-Bado-KF-Manual_2.2009.pdf, zuletzt geprüft am 20.07.2016.

21.

Herschbach, P., Weis, J. (Hg.) (2010). Screeningverfahren in der Psychoonkologie. Testinstrumente zur Identifikation betreuungsbedürftiger KrebspatientenEine Empfehlung der PSO für die psychoonkologische Behandlungspraxis. 2. Aufl. Deutsche Krebsgesellschaft (DKG). Berlin. Online verfügbar unter https://www.dapo-ev.de/fileadmin/templates/pdf/pso_broschuere2.pdf, zuletzt geprüft am 21.07.2016.

22.

Herschbach, P., Book, K., Brandl, T., Keller, M., & Marten-Mittag, B. (2008). The Basic Documentation for Psycho-Oncology (PO-Bado). An expert rating scale for the psychosocial experience of cancer patients. Onkologie, 31(11), 591–596. https://doi.org/10.1159/000162287.CrossRefPubMed

23.

Hinz, A., & Schwarz, R. (2001). Angst und Depression in der Allgemeinbevölkerung. Eine Normierungsstudie zur Hospital Anxiety and Depression Scale. Psychotherapie, Psychosomatik, medizinische Psychologie, 51(5), 193–200. https://doi.org/10.1055/s-2001-13279.CrossRefPubMed

24.

Walker, J., Postma, K., McHugh, G. S., Rush, R., Coyle, B., Strong, V., et al. (2007). Performance of the Hospital Anxiety and Depression Scale as a screening tool for major depressive disorder in cancer patients. Journal of Psychosomatic Research, 63(1), 83–91. https://doi.org/10.1016/j.jpsychores.2007.01.009.CrossRefPubMed

25.

Herrmann-Lingen, C., Buss, U., Snaith, R. P. (2011). HADS-D. Hospital Anxiety and Depression Scale Deutsche Version. Göttingen: Hogrefe.

26.

Herschbach, P., Marten-Mittag, B., & Henrich, G. (2003). Revision und psychometrische Prüfung des Fragebogen zur Belastung von Krebskranken (FBK-R23). Zeitschrift für Medizinische Psychologie, 12(2), 69–76.

27.

Book, K., Marten-Mittag, B., Henrich, G., Dinkel, A., Scheddel, P., Sehlen, S., et al. (2011). Distress screening in oncology-evaluation of the Questionnaire on Distress in Cancer Patients-short form (QSC-R10) in a German sample. Psycho-oncology, 20(3), 287–293. https://doi.org/10.1002/pon.1821.CrossRefPubMed

28.

Dietmaier, T., Paepke, D. D., Hapfelmeier, D. A., Große Lackmann, K., & Kiechle, P. D. M. (2016). Auswertung des FBK-R10 Fragebogens zur aktuellen Belastungssituation und Bedarf an psychotherapeutischer Behandlung bei Patientinnen mit Mamma- und Ovarialkarzinom. Geburtshilfe und Frauenheilkunde. https://doi.org/10.1055/s-0036-1593047.CrossRef

29.

Dietmaier, T., Nest, A., Hapfelmeier, A., Große Lackmann, K., Kiechle, M., & Paepke, D. (2017). Evaluation of psychological distress with the FBK-R10 survey in breast cancer patients. The Breast, 32, S52. https://doi.org/10.1016/S0960-9776(17)30185-6.CrossRef

30.

Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., et al. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30. A quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85(5), 365–376. https://doi.org/10.1093/jnci/85.5.365.CrossRefPubMed

31.

Fayers, P. M., Aaronson, N. K., Bjordal, K., Groenvold, M., Curran, D., & Bottomley, A. (2001). The EORTC QLQ-C30 Scoring Manual (3rd ed.). Brussels: EORTC.

32.

Scott, N. W., Fayers, P. M., Aaronson, N. K., Bottomley, A., de Graeff, A., Groenvold, M., et al. (2008). EORTC QLQ-C30 Reference Values. This manual presents reference data for the QLQ-C30 based upon data provided by EORTC Quality of Life Group Members and other users of the QLQ-C30 July 2008. On behalf of the EORTC Quality of Life Group.

33.

Lamers, J., Hartmann, M., Goldschmidt, H., Brechtel, A., Hillengass, J., & Herzog, W. (2013). Psychosocial support in patients with multiple myeloma at time of diagnosis. Who wants what? Psycho-oncology, 22(10), 2313–2320. https://doi.org/10.1002/pon.3284.CrossRefPubMed

34.

Hall, A. E., Sanson-Fisher, R. W., Lynagh, M. C., Tzelepis, F., & D'Este, C. (2015). What do haematological cancer survivors want help with? A cross-sectional investigation of unmet supportive care needs. BMC Research Notes, 8, 221. https://doi.org/10.1186/s13104-015-1188-7.CrossRefPubMedPubMedCentral

35.

Barata, A., Wood, W. A., Choi, S. W., & Jim, H. S. L. (2016). Unmet needs for psychosocial care in hematologic malignancies and hematopoietic cell transplant. Current Hematologic Malignancy Reports, 11(4), 280–287. https://doi.org/10.1007/s11899-016-0328-z.CrossRefPubMed

36.

Marten-Mittag, B., Book, K., Buchhold, B., Dinkel, A., Grundobler, B., Henrich, G., et al. (2015). The Basic Documentation for Psycho-Oncology Short Form (PO-Bado SF)—An expert rating scale for distress screening: Development and psychometric properties. Psycho-oncology, 24(6), 653–660. https://doi.org/10.1002/pon.3708.CrossRefPubMed

37.

Senf, B., Brandt, H., Dignass, A., Kleinschmidt, R., & Kaiser, J. (2010). Psychosocial distress in acute cancer patients assessed with an expert rating scale. Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer, 18(8), 957–965. https://doi.org/10.1007/s00520-010-0850-9.CrossRef

38.

Herschbach, P., Book, K., Brandl, T., Keller, M., Lindena, G., Neuwöhner, K., et al. (2008). Psychological distress in cancer patients assessed with an expert rating scale. British Journal of Cancer, 99(1), 37–43. https://doi.org/10.1038/sj.bjc.6604420.CrossRefPubMedPubMedCentral

39.

Goerling, U., Odebrecht, S., Schiller, G., & Schlag, P. M. (2006). Psychosozialer Betreuungsbedarf bei stationären Tumorpatienten. Untersuchungen an einer chirurgisch-onkologischen Schwerpunktklinik. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 77(1), 41–46. https://doi.org/10.1007/s00104-005-1094-y.CrossRefPubMed

40.

Stadelmaier, N., Gana, K., Saada, Y., Duguey-Cachey, O., & Quintard, B. (2017). Psychometric Properties of the French Adaptation of the Basic Documentation for Psycho-Oncology (Po-Bado). A Distress Screening Tool. Behavior Therapy, 48(5), 596–602. https://doi.org/10.1016/j.beth.2016.12.001.CrossRefPubMed

41.

Mehnert, A., Hartung, T. J., Friedrich, M., Vehling, S., Brähler, E., Härter, M., et al. (2018). One in two cancer patients is significantly distressed. Prevalence and indicators of distress. Psycho-oncology, 27(1), 75–82. https://doi.org/10.1002/pon.4464.CrossRefPubMed

42.

Giesinger, J. M., Kuijpers, W., Young, T., Tomaszewski, K. A., Friend, E., Zabernigg, A., et al. (2016). Thresholds for clinical importance for four key domains of the EORTC QLQ-C30. Physical functioning, emotional functioning, fatigue and pain. Health and Quality of Life Outcomes, 14, 87. https://doi.org/10.1186/s12955-016-0489-4.CrossRefPubMedPubMedCentral

43.

Daniëls, L. A., Oerlemans, S., Krol, A. D. G., Creutzberg, C. L., & van de Poll-Franse, L. V. (2014). Chronic fatigue in Hodgkin lymphoma survivors and associations with anxiety, depression and comorbidity. British Journal of Cancer, 110(4), 868–874. https://doi.org/10.1038/bjc.2013.779.CrossRefPubMedPubMedCentral

44.

Skarstein, J., Aass, N., Fosså, S. D., Skovlund, E., & Dahl, A. A. (2000). Anxiety and depression in cancer patients. Relation between the Hospital Anxiety and Depression Scale and the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire. Journal of psychosomatic research, 49(1), 27–34. https://doi.org/10.1016/S0022-3999(00)00080-5.CrossRefPubMed

Title: Quality of life and distress assessed with self and external assessment screening tools in patients with hematologic malignancies attending treatment in an acute hospital
Authors: Bianca Senf
Kirsten Grabowski
Natascha Spielmann
Jens Fettel
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keywords: Psycho-oncology
Psycho-oncology
Published in: Quality of Life Research / Issue 12/2020
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-020-02602-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Quality of life and distress assessed with self and external assessment screening tools in patients with hematologic malignancies attending treatment in an acute hospital

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 12/2020

Quality of life in a real-world cohort of advanced breast cancer patients: a study of the SONABRE Registry

EQ-5D-3L health status and health state utilities of the oldest-old (85 +) in Germany: results from the AgeCoDe-AgeQualiDe study

Six and eight weeks injection frequencies of bevacizumab are non-inferior to the current four weeks injection frequency for quality of life in neovascular age-related macular degeneration: a randomized controlled trial

Patient-reported outcome measures (PROMs): can they be used to guide patient-centered care and optimize outcomes in total knee replacement?

Underlying dimensions of the EORTC QLQ-C30 in a Cuban population of patients with advanced non-small cell lung cancer

The importance of development standards for anchoring vignettes: an illustrative example from pediatric localized scleroderma quality of life