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Psychiatric Quarterly
Published in: Psychiatric Quarterly 3/2019

01-09-2019 | Schizophrenia | Original Paper

Quality of Life in Schizophrenia: A Meta-Analysis of Comparative Studies

Authors: Min Dong, Li Lu, Ling Zhang, Yun-Shu Zhang, Chee H. Ng, Gabor S. Ungvari, Gang Li, Xiangfei Meng, Gang Wang, Yu-Tao Xiang

Published in: Psychiatric Quarterly | Issue 3/2019

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Abstract

Studies and findings regarding the impact of schizophrenia on quality of life (QOL) has been highly variable. This meta-analysis compared QOL between schizophrenia subjects and healthy controls with a focus on standardized measures. A systematic literature search was conducted through Pubmed, PsycINFO, EMBASE, Cochrane Library and Web of Science databases. Only studies using the World Health Organization Quality of Life (WHOQOL) or its brief version or the Short Form-36 Health Survey (SF-36) were included. Fifteen case-control studies with 2195 schizophrenia subjects and 1508 healthy controls were included in this meta-analysis. The WHOQOL/WHOQOL-BREF score was significantly lower in physical health (SMD = -1.80, 95% CI: -2.31 to −1.28, P < 0.001), psychological health (SMD = -1.28, 95% CI: -1.72 to −0.83, P < 0.001), social relationships (SMD = -1.60, 95% CI: -2.05 to −1.15, P < 0.001), and environment domains (SMD = -0.98, 95% CI: -1.38 to −0.59, P < 0.001) in schizophrenia subjects compared to controls. The SF-36 score was significantly lower in both physical (SMD = -1.09, 95% CI: -1.41 to −0.76, P < 0.001 and mental health domains (SMD = -2.08, 95% CI: -3.58 to −0.59, P = 0.006) in schizophrenia subjects than in controls. Subgroup and meta-regression analyses found that age, male gender, illness duration and income have significant moderating effects on QOL. The meta-analysis of studies with standardized measures confirmed that QOL in schizophrenia subjects is significantly lower than healthy controls. Effective interventions should be developed to improve QOL for this population.
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Metadata
Title
Quality of Life in Schizophrenia: A Meta-Analysis of Comparative Studies
Authors
Min Dong
Li Lu
Ling Zhang
Yun-Shu Zhang
Chee H. Ng
Gabor S. Ungvari
Gang Li
Xiangfei Meng
Gang Wang
Yu-Tao Xiang
Publication date
01-09-2019
Publisher
Springer US
Keyword
Schizophrenia
Published in
Psychiatric Quarterly / Issue 3/2019
Print ISSN: 0033-2720
Electronic ISSN: 1573-6709
DOI
https://doi.org/10.1007/s11126-019-09633-4

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