Top

Pituitary

Published in:

14-07-2022 | Pituitary Adenoma

Predictive value of macular ganglion cell-inner plexiform layer thickness in visual field defect of pituitary adenoma patients: a case-control study

Authors: Li Xia, Jia Wenhui, Yang Xiaowen, Xie Wenfang, Zhang Wei, Hu Yanjun, Peng Xiaoyan

Published in: Pituitary | Issue 4/2022

Abstract

Objective

The present study explored the association between preoperative macular ganglion cell-inner plexiform layer thickness (GCIPL) and retinal nerve fiber layer thickness (RNFL) measured by optical coherence tomography (OCT) and the recovery of visual field (VF) defect after surgery in pituitary adenoma patients.

Methods

This case-control study included patients with pituitary adenoma in the Neurosurgery Department of Shanxi Provincial People’s Hospital between October 2019 and June 2021. Cranial MRI examination, three-dimensional OCT, and VF testing (Humphrey Field Analyzer II750) were performed before and at 6months after the surgery.

Results

Fifty-three pituitary adenoma patients (81 eyes) were enrolled; 15 patients (23 eyes) were in the visual field did not recover group (VFNR), and 38 patients (58 eyes) were in the visual field recovered group (VFR). The temporal RNFL (P = 0.002) and average RNFL (P = 0.009) in the VFNR group were significantly lower than in the VFR group. The superior nasal GCIPL (P = 0.001), inferior nasal GCIPL (P = 0.001) and average GCIPL (P = 0.01) were significantly lower in the VFNR group than in the VFR group (all P < 0.01).The multivariable logistic regression analysis showed that nasal inferior GCIPL was an independent risk factor for VF recovery (odds ratio (OR) = 1.376,95% confidence interval (CI):1.089-1.739,P = 0.007). In the received operating characteristics (ROC) analysis, the area under the ROC curve (AUROCs) was the highest for nasal inferior GCIPL (AUROC = 0.739).

Conclusions

In patients who underwent resection of pituitary adenoma, nasal inferior GCIPL was an independent risk factor of visual field defect recover after surgery.

Russ S, Anastasopoulou C, Shafiq I (2022) Pituitary Adenoma

Ntali G, Wass JA (2018) Epidemiology, clinical presentation and diagnosis of non-functioning pituitary adenomas. Pituitary 21(2):111–118. https://doi.org/10.1007/s11102-018-0869-3CrossRefPubMed

AlMalki MH, Ahmad MM, Brema I et al (2020) Contemporary Management of Clinically Non-functioning Pituitary Adenomas: A Clinical Review. Clin Med Insights:Endocrinology Diabetes 13:1–13. https://doi.org/10.1177/1179551420932921CrossRef

Bialer OY, Cohen GN,Toledano H et al (2013) Retinal NFL thinning on OCT correlates with visual field loss in pediatric craniopharyngioma. Can J Ophthalmol 48(6):494–499. .https://doi.org/10.101/j.jcjo.2013.05.00CrossRef

Banc A, Stan C, Florian IS (2018) Optical coherence tomography as a marker of vision in children with optic pathway gliomas. Childs Nerv Syst 34(1):51–60. https://doi.org/10.1007/s00381-017-3578-8CrossRefPubMed

Jariyakosol S, Peragallo JH (2015) The Effects of Primary Brain Tumors on Vision and Quality of Life in Pediatric Patients. Semin Neurol 35(5):587–598. https://doi.org/10.1055/s-0035-1563571CrossRefPubMed

Peragallo JH (2019) Visual function in children with primary brain tumors. Curr Opin Neurol 32(1):75–81. https://doi.org/10.1097/WCO.0000000000000644CrossRefPubMedPubMedCentral

Bhende M, Shetty S, Parthasarathy MK et al (2018) Optical coherence tomography: A guide to interpretation of common macular diseases. Indian J Ophthalmol 66(1):20–35. https://doi.org/10.4103/ijo.IJO_902_17CrossRefPubMedPubMedCentral

Fujii K, Kubo T,Otake H et al (2022) Expert consensus statement for quantitative measurement and morphological assessment of optical coherence tomography: update 2022. Cardiovasc Interv Ther 37(2):248–254. https://doi.org/10.1007/s12928-022-00845-3CrossRefPubMed

10.

Hood DC( (2019) Does Retinal Ganglion Cell Loss Precede Visual Field Loss in Glaucoma? J Glaucoma 28(11):945–951. https://doi.org/10.1097/IJG.0000000000001380CrossRefPubMedPubMedCentral

11.

Asensio-Sanchez VM, Foncubierta J (2016) Progressive loss of vision caused by asymptomatic pituitary macroadenoma: role of OCT. Int Med Case Rep J 9:291–293. https://doi.org/10.2147/IMCRJ.S113339CrossRefPubMedPubMedCentral

12.

Danesh-Meyer HV, Wong A, Papchenko T et al (2015) Optical coherence tomography predicts visual outcome for pituitary tumors. J Clin Neurosci 22(7):1098–1104. https://doi.org/10.1016/j.jocn.2015.02.001CrossRefPubMed

13.

Jeong AR, Kim EY,Kim NR (2016) Preferential Ganglion Cell Loss in the Nasal Hemiretina in Patients With Pituitary Tumor. J Neuroophthalmol 36(2):152–155. https://doi.org/10.1097/WNO.0000000000000331CrossRefPubMed

14.

Tieger MG, Hedges TR, Ho J et al (2017) Ganglion Cell Complex Loss in Chiasmal Compression by Brain Tumors. J Neuroophthalmol 37(1):7–12. https://doi.org/10.1097/WNO.0000000000000424CrossRefPubMedPubMedCentral

15.

Cennamo G, Auriemma RS,Cardone D et al (2015) Evaluation of the retinal nerve fibre layer and ganglion cell complex thickness in pituitary macroadenomas without optic chiasmal compression. Eye (Lond) 29(6):797–802. https://doi.org/10.1038/eye.2015.35CrossRef

16.

Yum HR, Park SH, Park Hae-Young L et al (2016) Macular Ganglion Cell Analysis Determined by Cirrus HD Optical Coherence Tomography for Early Detecting Chiasmal Compression. PLoS ONE 11(4):e0153064. https://doi.org/10.1371/journal.pone.0153064CrossRefPubMedPubMedCentral

17.

Shin HY, Park HY, Jung KI et al (2013) Comparative study of macular ganglion cell-inner plexiform layer and peripapillary retinal nerve fiber layer measurement: structure-function analysis. Invest Ophthalmol Vis Sci 54(12):7344–7353. https://doi.org/10.1167/iovs.13-12667CrossRefPubMed

18.

Grkovic D, Davidovic S (2016) Prognotic factors for postoperative visual outcome in surgically treated suprasellar meningiomas. Med Pregl 69(5–6):146–152. https://doi.org/10.2298/mpns1606146gCrossRefPubMed

19.

Sun MZhangZQ, Ma CY et al (2017) Predictive factors of visual function recovery after pituitary adenoma resection: a literature review and Meta-analysis. Int J Ophthalmol 10(11):1742–1750. https://doi.org/10.18240/ijo.2017.11.17CrossRefPubMedPubMedCentral

20.

Zhang XMaJ, Wang YH et al (2019) The correlation of ganglion cell layer thickness with visual field defect in non-functional pituitary adenoma with chiasm compression]. Zhonghua Yan Ke Za Zhi 55(3):186–194. https://doi.org/10.3760/cma.j.issn.0412-4081.2019.03.007CrossRefPubMed

21.

Danesh-Meyer HV, Papchenko T, Savino PJ et al (2008) In vivo retinal nerve fiber layer thickness measured by optical coherence tomography predicts visual recovery after surgery for parachiasmal tumors. Invest Ophthalmol Vis Sci 49(5):1879–1885. https://doi.org/10.1167/iovs.07-1127CrossRef

22.

Yoneoka Y, Hatase T, Watanabe N et al (2015) Early morphological recovery of the optic chiasm is associated with excellent visual outcome in patients with compressive chiasmal syndrome caused by pituitary tumors. Neurol Res 37(1):1–8. https://doi.org/10.1179/1743132814Y.0000000407CrossRefPubMed

23.

Monteiro ML, Zambon BK,Cunha LP (2010) Predictive factors for the development of visual loss in patients with pituitary macroadenomas and for visual recovery after optic pathway decompression. Can J Ophthalmol 45(4):404–408. https://doi.org/10.3129/i09-276CrossRefPubMed

24.

Moon CH, Kim SC (2011) BT Visual Prognostic Value of Optical Coherence Tomography and Photopic Negative Response in Chiasmal Compression. Invest Ophthalmol Vis Sci 52(11):8527.https://doi.org/10.1167/iovs.11-8034

25.

Ohkubo S, Higashide C, Takeda H et al (2011) Relationship between macular ganglion cell complex parameters and visual fifield parameters after tumor resection in chiasmal compression. Jpn J Ophthalmol 56:68–75. https://doi.org/10.1007/s10384-011-0093-4CrossRef

Title: Predictive value of macular ganglion cell-inner plexiform layer thickness in visual field defect of pituitary adenoma patients: a case-control study
Authors: Li Xia
Jia Wenhui
Yang Xiaowen
Xie Wenfang
Zhang Wei
Hu Yanjun
Peng Xiaoyan
Publication date: 14-07-2022
Publisher: Springer US
Keyword: Pituitary Adenoma
Published in: Pituitary / Issue 4/2022
Print ISSN: 1386-341X
Electronic ISSN: 1573-7403
DOI: https://doi.org/10.1007/s11102-022-01248-6

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Predictive value of macular ganglion cell-inner plexiform layer thickness in visual field defect of pituitary adenoma patients: a case-control study

Abstract

Objective

Methods

Results

Conclusions

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 4/2022

Preoperative differentiation of hypophysitis and pituitary adenomas using a novel clinicoradiologic scoring system

11C-methionine PET aids localization of microprolactinomas in patients with intolerance or resistance to dopamine agonist therapy

A patient-reported outcome measure for patients with pituitary adenoma undergoing transsphenoidal surgery

A comparison of macular ganglion cell and retinal nerve fibre layer optical coherence tomographic parameters as predictors of visual outcomes of surgery for pituitary tumours

Clinical and radiographic assessment of peripheral joints in controlled acromegaly

Proportion and predictors of Hypogonadism Recovery in Men with Macroprolactinomas treated with dopamine agonists

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page