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Pituitary
Published in: Pituitary 5/2015

01-10-2015

Quality of life (QoL) impairments in patients with a pituitary adenoma: a systematic review of QoL studies

Authors: Cornelie D. Andela, Margreet Scharloo, Alberto M. Pereira, Ad A. Kaptein, Nienke R. Biermasz

Published in: Pituitary | Issue 5/2015

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Abstract

Purpose

Pituitary adenomas give rise to physical and psychological symptoms, which may persist after biochemical cure. Growing attention has been paid to quality of life (QoL) in these patients. We aimed to systematically analyze QoL assessment methods and QoL outcome in these patients.

Methods

We conducted a systematic literature search up to January 2014 in PubMed, Web of Knowledge, PsycInfo and EMBASE.

Results

102 papers assessing QoL in patients with a pituitary adenoma were included. In clinical (original) studies in which QoL was the primary outcome parameter (n = 54), 19 studies combined a generic questionnaire with a disease-specific questionnaire. QoL was found to be impaired in patients with active disease relative to controls, and generally improved during biochemical cure. However, no normalization occurred, with patients with remitted Cushing’s disease demonstrating the smallest improvement. Somatic factors (e.g., hypopituitarism, sleep characteristics), psychological factors (illness perceptions) and health care environment (rural vs. urban) were identified as influencing factors. Intervention studies (predominantly evaluating medical interventions) have been found to improve QoL.

Conclusions

The growing number of studies assessing QoL generally described the negative impact of pituitary adenomas. QoL research in this patient group could be further elaborated by the development of disease-specific questionnaires for prolactinoma and non-functioning adenoma, consequent use of generic and disease-specific questionnaires and using a long-term (longitudinal) follow-up. Surgical and pharmacological interventions improve but not normalize QoL. We postulate that there might be margin for further improvement of QoL, for instance by using psychosocial interventions, in addition to optimal medical treatment.
Appendix
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Metadata
Title
Quality of life (QoL) impairments in patients with a pituitary adenoma: a systematic review of QoL studies
Authors
Cornelie D. Andela
Margreet Scharloo
Alberto M. Pereira
Ad A. Kaptein
Nienke R. Biermasz
Publication date
01-10-2015
Publisher
Springer US
Published in
Pituitary / Issue 5/2015
Print ISSN: 1386-341X
Electronic ISSN: 1573-7403
DOI
https://doi.org/10.1007/s11102-015-0636-7

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