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Pituitary
Published in: Pituitary 2/2015

01-04-2015

Clinical and biochemical manifestations of Cushing’s

Authors: Georgia Ntali, Ashley Grossman, Niki Karavitaki

Published in: Pituitary | Issue 2/2015

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Abstract

Introduction

Cushing’s syndrome is associated with a number of clinical manifestations and co-morbidities which may not resolve even after long-term remission leading to excessive mortality.

Materials and methods

This review summarizes the main manifestations of Cushing’s syndrome (active or in remission) with particular focus on data from recently published literature.

Conclusion

Obesity and metabolic alterations, hypertension and cardio/cerebrovascular complications, hypercoagulability/thromboembolism, neuropsychiatric, muscle/skeletal and immune consequences remain the most challenging. Cardiovascular consequences and immunosuppression determine the main causes of death in Cushing’s syndrome necessitating early intervention when possible.
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Metadata
Title
Clinical and biochemical manifestations of Cushing’s
Authors
Georgia Ntali
Ashley Grossman
Niki Karavitaki
Publication date
01-04-2015
Publisher
Springer US
Published in
Pituitary / Issue 2/2015
Print ISSN: 1386-341X
Electronic ISSN: 1573-7403
DOI
https://doi.org/10.1007/s11102-014-0631-4

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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