Top

Pituitary

Published in:

01-12-2014

Prolactin levels in manganese-exposed male welders

Authors: Engin Tutkun, Sedat Abuşoğlu, Hinç Yılmaz, Meşide Gündüzöz, Nilgün Gıynas, Ceylan Demir Bal, Ali Ünlü

Published in: Pituitary | Issue 6/2014

Abstract

Purpose

Early studies on manganese (Mn) exposure have demonstrated that this transition metal affects dopamine neurotransmission. Dopamine serves as a tonic inhibitor of prolactin release in the anterior hypophysis. Our aim was to determine the relation between serum prolactin levels and manganese-exposure.

Methods

Whole blood was collected from 95 non-exposed control subjects and 179 manganese-exposed male welders. Whole blood manganese was analyzed by Inductively Coupled Plasma—Mass Spectrometer on Agilent 7700 (Agilent Technologies, USA). Serum prolactin levels (PRL), aspartate transaminase (AST), alanine transaminase (ALT), urea, creatinine, soduim (Na), potassium (K) were analyzed by immunological and spectrophotometric methods on Roche E170 Modular System (Roche Diagnostics, Mannheim, Germany).

Results

The mean ages for control and manganese-exposed group were 40.5 ± 7.8 and 39.5 ± 8.7, respectively (p = 0.258). The mean working period (years) for control and manganese-exposed group were 17.4 ± 9.8 and 18.2 ± 7.7 years, respectively (p = 0.581). Serum AST and potassium levels were significantly higher in control group than manganese-exposed group (p = 0.002 and p = 0.048, respectively) and body-mass index (BMI) was significantly lower in control group than manganese-exposed group (p = 0.033). There was a significantly positive correlation between whole blood manganese levels and serum prolactin (r = 0.860, p < 0.001). Serum ALT levels were positively correlated with serum AST, urea and sodium (r = 0.315, p < 0.001; r = 0.121, p = 0.046; r = 0.130, p = 0.031).

Conclusions

Serum prolactin level is a diagnostic marker for determining the effect of manganese-exposure.

Vieira MC, Torronteras R, Cordoba F, Canalejo A (2012) Acute toxicity of manganese in goldfish Carassius auratus is associated with oxidative stress and organ specific antioxidant response. Ecotoxicol Environ Saf 78:212–217PubMedCrossRef

Bouchard M, Laforest F, Vandelac L, Bellinger D, Mergler D (2007) Hair manganese and hyperactive behaviors: pilot study of school-age children exposed through tap water. Environ Health Perspect 115(1):122–127PubMedCentralPubMedCrossRef

Erikson KM, Syversen T, Aschner JL, Aschner M (2005) Interactions between excessive manganese exposures and dietary iron-deficiency in neurodegeneration. Environ Toxicol Pharmacol 19(3):415–421PubMedCrossRef

Mergler D, Huel G, Bowler R, Iregren A, Belanger S, Baldwin M, Tardif R, Smargiassi A, Martin L (1994) Nervous system dysfunction among workers with long-term exposure to manganese. Environ Res 64(2):151–180PubMedCrossRef

Aschner M (2000) Manganese: brain transport and emerging research needs. Environ Health Perspect 108:429–432PubMedCentralPubMedCrossRef

Yamada M, Ohno S, Okayasu I, Okeda R, Hatakeyama S, Watanabe H, Ushio K, Tsukagoshi H (1986) Chronic manganese poisoning: a neuropathological study with determination of manganese distribution in the brain. Acta Neuropathol 70(3–4):273–278PubMedCrossRef

Lucchini R, Albini E, Placidi D, Gasparotti R, Pigozzi MG, Montani G, Alessio L (2000) Brain magnetic resonance imaging and manganese exposure. Neurotoxicology 21(5):769–775PubMed

Nelson K, Golnick J, Korn T, Angle C (1993) Manganese encephalopathy: utility of early magnetic resonance imaging. Br J Ind Med 50(6):510–513PubMedCentralPubMed

Chang Y, Kim Y, Woo ST, Song HJ, Kim SH, Lee H, Kwon YJ, Ahn JH, Park SJ, Chung IS, Jeong KS (2009) High signal intensity on magnetic resonance imaging is a better predictor of neurobehavioral performances than blood manganese in asymptomatic welders. Neurotoxicology 30(4):555–563PubMedCrossRef

10.

Dietz MC, Ihrig A, Wrazidlo W, Bader M, Jansen O, Triebig G (2001) Results of magnetic resonance imaging in long-term exposed manganese dioxide-exposed workers. Environ Res 85(1):37–40PubMedCrossRef

11.

Truong AT, Duez C, Belayew A, Renard A, Pictet R, Bell GI, Martial JA (1984) Isolation and characterization of the human prolactin gene. EMBO J 3:429–437PubMedCentralPubMed

12.

Owerbach D, Rutter WJ, Cooke NE, Martial JA, Shows TB (1981) The prolactin gene is located on chromosome 6 in humans. Science 212:815–816PubMedCrossRef

13.

Freeman ME, Kanyicska B, Lerant A, Nagy G (2000) Prolactin: structure, function and regulation of secretion. Physiol Rev 80(4):1523–1631PubMed

14.

Goffin V, Bouchard B, Ormandy CJ, Weimann E, Ferrog F, Touraine P, Bole-Feysat C, Maaskant RA, Clement-Lacroix P, Edery M, Binart N, Kelly PA (1998) Prolactin: a hormone at the crossroad of neuroimmunoendocrinology. Ann NY Acad Sci 840:498–509PubMedCrossRef

15.

Walker SE, Allen SH, McMurray RW (1993) Prolactin and autoimmune disease. Trends Endocrinol Metab 4(5):147–151PubMedCrossRef

16.

Popek W, Dietrich G, Glogowski J, Demska-Zakes K, Drag-Kozak E, Sionkowski J, Luszczek-Trojan E, Epler P, Demianowicz W, Sarosiek B, Kowalski R, Jankun M, Zakes Z, Krol J, Czerniak S, Szczepkowski M (2006) Influence of heavy metals and 4-nonylphenol on reproductive function in fish. Reprod Biol 1(6):175–188

17.

Jones DC, Miller GW (2008) The effects of environmental neurotoxicants on the dopaminergic system: a possible role in drug addiction. Biochem Pharmacol 76:569–581PubMedCrossRef

18.

Ben-Jonathan N, LaPensee CR, LaPensee EW (2008) What can we learn from rodents about prolactin in humans? Endocr Rev 29:1–41PubMedCentralPubMedCrossRef

19.

Giorgianni CM, D’Arrigo G, Brecciaroli R, Abbate A, Spatari G, Tringali MA, Gangemi S, De Luca A (2012) Neurocognitive effects in welders exposed to aluminium. Toxicol Ind Health. Aud 22

20.

Kim Y, Bowler RM, Abdelouahab N, Harris M, Gocheva V, Roels HA (2011) Motor function in adults of an Ohio community with environmental manganese exposure. Neurotoxicology 32(5):606–614PubMedCrossRef

21.

Lucchini RG, Guazetti S, Zoni S, Donna F, Peter S, Zacco A, Salmistraro M, Bontempi E, Zimmerman NJ, Smith DR (2012) Tremor, olfactory and motor changes in Italian adolescents exposed to historical ferro-manganese emission. Neurotoxicology 33(4):687–696PubMedCentralPubMedCrossRef

22.

Racette BA, Criswell SR, Lundin JI, Hobson A, Seixas N, Kotzbauer PT, Evanoff BA, Perlmutter JS, Zhang J, Sheppard L, Checkoway H (2012) Increased risk of parkinsonism associated with welding exposure. Neurotoxicology 33(5):1356–1361PubMedCrossRef

23.

Miyake Y, Tanaka K, Fukushima W, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M (2012) Fukuoka kinki parkinson’s disease study group dietary intake of metals and risk of Parkinson’s disease: a case-control study in Japan. J Neurol Sci 306(1–2):98–102

24.

Racette BA, Antenor JA, McGee-Minnich L, Moerlein SM, Videen TO, Kotagal V, Perlmutter JS (2005) [18F] FDOPA PET and clinical features in parkinsonism due to manganism. Mov Disord 20(4):492–496PubMedCrossRef

25.

Stampfer MJ (2009) Welding occupations and mortality from Parkinson’s disease and other neurodegenerative diseases among United States men, 1985–1999. J Occup Environ Hyg 6(5):267–272PubMedCrossRef

26.

Cersosimo MG, Koller WC (2006) The diagnosis of manganese-induced parkinsonism. Neurotoxicology 27(3):340–346PubMedCrossRef

27.

Gorell JM, Johnson CC, Rybicki BA, Peterson EL, Kortsha GX, Brown GG, Richardson RJ (1999) Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson’s disease. Neurotoxicology 20(2–3):239–247PubMed

28.

Eriksson H, Magiste K, Plantin LO, Fonnum F, Hedström KG, Theodorsson-Norheim E, Kristensson K, Stalberg E, Heilbronn E (1987) Effects of manganese oxide on monkeys as revealed by a combined neurochemical, histological and neurophysiological evaluation. Arch Toxicol 61(1):46–52PubMedCrossRef

29.

Calabresi P, Ammassari-Teule M, Gubellini P, Sancesario G, Morello M, Centonze D, Marfia GA, Saulle E, Passino E, Picconi B, Bernardi G (2001) A synaptic mechanism underlying the behavioral abnormalities induced by manganese intoxication. Neurobiol Dis 8(3):419–432PubMedCrossRef

30.

Ingersoll RT, Montgomery EB Jr, Aposhian HV (1999) Central nervous system toxicity of manganese. II: cocaine or reserpine inhibit manganese concentration in the rat brain. Neurotoxicology 20(2–3):467–476PubMed

31.

Shinotoh H, Snow BJ, Chu NS, Huang CC, Lu CS, Lee C, Takahashi H, Calne DB (1997) Presynaptic and postsynaptic striatal dopaminergic function in patients with manganese intoxication: a positron emission tomography study. Neurology 48(4):1053–1056PubMedCrossRef

32.

Wolters EC, Huang CC, Clark C, Peppard RF, Okada J, Chu NS, Adam MJ, Ruth TJ, Li D, Calne DB (1989) Positron emission tomography in manganese intoxication. Ann Neurol 26(5):647–651PubMedCrossRef

33.

Gwiazda RH, Lee D, Sheridan J, Smith DR (2002) Low cumulative manganese exposure affects striatal GABA but not dopamine. Neurotoxicology 23(1):69–76PubMedCrossRef

34.

Bagga P, Patel AB (2012) Regional cerebral metabolism in mouse under chronic manganese exposure: implications for manganism. Neurochem Int 60(2):177–185PubMedCrossRef

35.

Bouilleret V, Cardamone L, Liu C, Koe AS, Fang K, Williams JP, Myers DE, O’Brien TJ, Jones NC (2011) Confounding neurodegenerative effects of manganese for in vivo MR imaging in rat models of brain insults. J Magn Reson Imaging 34(4):774–784PubMedCrossRef

36.

Yoon M, Schroeter JD, Nong A, Taylor MD, Dorman DC, Andersen ME, Clewell HJ (2011) Physiologically based pharmacokinetic modelling of fetal and neonatal manganese exposure in humans: describing manganese homeostasis during development. Toxicol Sci 122(2):297–316PubMedCrossRef

37.

Kim EA, Cheong HK, Joo KD, Shin JH, Lee JS, Choi SB, Kim MO, Lee lu J, Kang DM (2007) Effects of manganese exposure on the neuroendocrine system in welders. Neurotoxicology 28(2):263–269PubMedCrossRef

38.

Dos Santos AP, Lopes Santos M, Batoreu MC, Aschner M (2011) Prolactin is a peripheral marker of manganese neurotoxicity. Brain Res 1382:282–290CrossRef

39.

Montes S, Riojas-Rodriguez H, Sabido-Pedraza E, Rios C (2008) Biomarkers of manganese exposure in a population living close to a mine and mineral processing plant in Mexico. Environ Res 106(1):89–95PubMedCrossRef

40.

Montes S, Schilmann A, Riojas-Rodriguez H, Rodriguez-Agudelo Y, Solis-Vivanco R, Rodriguez-Doza lSL, Tristan-Lopez LA, Rios C (2011) Serum prolactin rises in Mexican school children exposed to airborne manganese. Environ Res 111(8):1302–1308PubMedCrossRef

41.

Myers JE, Thompson ML, Naik I, Theodorou P, Esswein E, Tassell H, Daya A, Renton K, Spies A, Paicker J, Young T, Jeebhay M, Ramushu S, London L, Rees DJ (2003) The utility of biological monitoring for manganese in ferroalloy smelter workers in South Africa. Neurotoxicology 24(6):875–883PubMedCrossRef

42.

Kim EA, Cheong HK, Joo KD, Shin JH, Lee JS, Choi SB, Kim MO, Lee Iu J, Kang DM (2007) Effect of manganese exposure on the neuroendocrine system in welders. Neurotoxicology 28(2):263–269PubMedCrossRef

43.

Lu L, Zhang LL, Li GJ, Guo W, Liang W, Zheng W (2005) Alteration of serum concentrations of manganese, iron, ferritin, and transferrin receptor following exposure to welding fumes among career welders. Neurotoxicology 26(2):257–265PubMedCentralPubMedCrossRef

Title: Prolactin levels in manganese-exposed male welders
Authors: Engin Tutkun
Sedat Abuşoğlu
Hinç Yılmaz
Meşide Gündüzöz
Nilgün Gıynas
Ceylan Demir Bal
Ali Ünlü
Publication date: 01-12-2014
Publisher: Springer US
Published in: Pituitary / Issue 6/2014
Print ISSN: 1386-341X
Electronic ISSN: 1573-7403
DOI: https://doi.org/10.1007/s11102-013-0545-6

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Prolactin levels in manganese-exposed male welders

Abstract

Purpose

Methods

Results

Conclusions

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 6/2014

Clinical and biochemical characteristic features of metastatic cancer to the sella turcica: an analytical review

Pasireotide monotherapy in Cushing’s disease: a single-centre experience with 5-year extension of phase III Trial

A novel mutation in SOX3 polyalanine tract: a case of kabuki syndrome with combined pituitary hormone deficiency harboring double mutations in MLL2 and SOX3

Pituitary carcinoma with fourth ventricle metastasis: treatment by excision and Gamma-knife radiosurgery

Tamoxifen as a therapeutic agent in acromegaly

Adamantinomatous craniopharyngiomas express tumor stem cell markers in cells with activated Wnt signaling: further evidence for the existence of a tumor stem cell niche?

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page