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Published in: Pituitary 1/2008

01-03-2008 | Case Report

An unusual association of a sellar gangliocytoma with a prolactinoma

Authors: Omar Serri, France Berthelet, Manon Bélair, Sophie Vallette, Sylvia L. Asa

Published in: Pituitary | Issue 1/2008

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Abstract

The simultaneous occurrence of a hypothalamic and sellar gangliocytoma with a pituitary prolactinoma is very rare. The explanation for such an association is not known. We describe the case of a woman who had a coexisting adjacent pituitary prolactinoma and gangliocytoma within the same sellar mass. The tumor cells of the gangliocytoma demonstrated expression of enkephalin, a product of proopiomelanocortin known to be a prolactin secretagogue. We postulate that in this patient there may be a link between gangliocytoma enkephalin and prolactin hypersecretion.
Literature
1.
go back to reference Geddes JF, Jansen GH, Robinson SF et al (2000) Gangliocytomas of the pituitary: a heterogeneous group of lesions with differing histogenesis. Am J Surg Pathol 24:607–613 Medline. doi:10.1097/00000478-200004000-00017 Geddes JF, Jansen GH, Robinson SF et al (2000) Gangliocytomas of the pituitary: a heterogeneous group of lesions with differing histogenesis. Am J Surg Pathol 24:607–613 Medline. doi:10.1097/00000478-200004000-00017
2.
go back to reference Towfighi J, Salam MM, McLendon RE, Powers S, Page RB (1996) Ganglion cell-containing tumors of the pituitary gland. Arch Pathol Lab Med 120:369–377PubMed Towfighi J, Salam MM, McLendon RE, Powers S, Page RB (1996) Ganglion cell-containing tumors of the pituitary gland. Arch Pathol Lab Med 120:369–377PubMed
3.
go back to reference Puchner MJA, Hermann HD (1998) Intrasellar pituitary gangliocytoma presenting with acromegaly: case report. Neurosurgery 42:1197–1199. letter Medline. doi:10.1097/00006123-199805000-00165 Puchner MJA, Hermann HD (1998) Intrasellar pituitary gangliocytoma presenting with acromegaly: case report. Neurosurgery 42:1197–1199. letter Medline. doi:10.1097/00006123-199805000-00165
4.
go back to reference Asada H, Otani M, Furuhata S, Inoue H, Toya S, Ogawa Y (1990) Mixed pituitary adenoma, gangliocytoma associated with acromegaly. Neurol Med Chir (Tokyo). 30:628–632 Medline Asada H, Otani M, Furuhata S, Inoue H, Toya S, Ogawa Y (1990) Mixed pituitary adenoma, gangliocytoma associated with acromegaly. Neurol Med Chir (Tokyo). 30:628–632 Medline
5.
go back to reference McCowen K, Glickmann JN, Black PM, Zervas NT, Lidov HGW, Garber JR (1999) Gangliocytoma masquerading as a prolactinoma. J Neurosurg 91:490–495 Medline McCowen K, Glickmann JN, Black PM, Zervas NT, Lidov HGW, Garber JR (1999) Gangliocytoma masquerading as a prolactinoma. J Neurosurg 91:490–495 Medline
6.
go back to reference Li JY, Racadot O, Kujas M, Kouadri M, Peillon F, Racadot J (1989) Immunocytochemistry of four mixed pituitary adenomas and intrasellar gangliocytomas associated with different clinical syndromes: acromegaly, amenorrhea-galactorrhea, Cushing’s disease and isolated tumoral syndrome. Acta Neuropathol (Berl) 77:320–328 Medline. doi:10.1007/BF00687585 Li JY, Racadot O, Kujas M, Kouadri M, Peillon F, Racadot J (1989) Immunocytochemistry of four mixed pituitary adenomas and intrasellar gangliocytomas associated with different clinical syndromes: acromegaly, amenorrhea-galactorrhea, Cushing’s disease and isolated tumoral syndrome. Acta Neuropathol (Berl) 77:320–328 Medline. doi:10.1007/BF00687585
7.
go back to reference Asa SL, Sheithauer BW, Bilbao JM et al (1984) A case for hypothalamic acromegaly: a clinico-pathological study of six patients with hypothalamic gangliocytomas producing growth hormone-releasing factor. J Clin Endocrinol Metab 58:796–802 Medline Asa SL, Sheithauer BW, Bilbao JM et al (1984) A case for hypothalamic acromegaly: a clinico-pathological study of six patients with hypothalamic gangliocytomas producing growth hormone-releasing factor. J Clin Endocrinol Metab 58:796–802 Medline
8.
go back to reference Molitch M. Pharmacologic resistance in prolactinoma patients (2005) Pituitary 8:43–52 Medline. doi:10.1007/s11102-005-5085-2 Molitch M. Pharmacologic resistance in prolactinoma patients (2005) Pituitary 8:43–52 Medline. doi:10.1007/s11102-005-5085-2
Metadata
Title
An unusual association of a sellar gangliocytoma with a prolactinoma
Authors
Omar Serri
France Berthelet
Manon Bélair
Sophie Vallette
Sylvia L. Asa
Publication date
01-03-2008
Publisher
Springer US
Published in
Pituitary / Issue 1/2008
Print ISSN: 1386-341X
Electronic ISSN: 1573-7403
DOI
https://doi.org/10.1007/s11102-007-0022-1

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