Skip to main content
Top
Published in: International Journal of Clinical Pharmacy 6/2017

Open Access 01-12-2017 | Research Article

Pharmacists’ confidence when providing pharmaceutical care on anticoagulants, a multinational survey

Authors: John Papastergiou, Nadir Kheir, Katerina Ladova, Silas Rydant, Fabio De Rango, Sotiris Antoniou, Reka Viola, Maria Dolores Murillo, Stephane Steurbaut, Filipa Alves da Costa

Published in: International Journal of Clinical Pharmacy | Issue 6/2017

Login to get access

Abstract

Background Guidelines on the management of orally anticoagulated patients are continuously evolving, leading to an increased need for pharmacists to be fully integrated in care provision. Objective To identify self-reported gaps in confidence among practicing pharmacists in the area of anticoagulation. Setting Pharmacists in different work settings in different countries. Method Cross-sectional international survey from October 2015 till November 2016 among pharmacists working in different settings to assess their level of confidence when delivering anticoagulants as well as to identify possible educational needs regarding this medication class. Validation of the survey was ensured. Results Responses from 4212 pharmacists originating from 18 countries were obtained. Pharmacists’ level of confidence was significantly higher (p < 0.001) when advising patients on vitamin K antagonists (VKAs) versus non-vitamin K antagonists (NOACs). In general, hospital pharmacists displayed higher confidence levels compared to community pharmacists when advising patients on anticoagulation (p < 0.001). Two distinct patterns of confidence levels emerged relating to basic and advanced pharmaceutical care. Confidence levels when providing advanced pharmaceutical care were significantly higher for Oceania and lower for South America (p < 0.005). Conclusions Pharmacists felt more confident in supporting patients receiving VKAs compared to the more recently introduced NOACs. With the increasing use of NOACs and the risks pertaining to anticoagulation therapy, it is essential to invest in education for pharmacists to address their knowledge gaps enabling them to confidently support patients receiving oral anticoagulants.
Appendix
Available only for authorised users
Literature
1.
go back to reference Jha AK, Larizgoitia I, Audera-Lopez C, Prasopa-Plaisier N, Waters H, Bates DW. The global burden of unsafe medical care: analytic modeling of observational studies. BMJ Qual Saf. 2013;22:809–15.CrossRefPubMed Jha AK, Larizgoitia I, Audera-Lopez C, Prasopa-Plaisier N, Waters H, Bates DW. The global burden of unsafe medical care: analytic modeling of observational studies. BMJ Qual Saf. 2013;22:809–15.CrossRefPubMed
3.
go back to reference Heit JA. Poster 68 presented at: American society of hematology. In: 47th Annual Meeting, Atlanta, GA, December 10–13, 2005. Heit JA. Poster 68 presented at: American society of hematology. In: 47th Annual Meeting, Atlanta, GA, December 10–13, 2005.
4.
go back to reference Chug SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ, et al. Worldwide epidemiology of atrial fibrillation: a global burden of disease 2010 study. Circulation. 2014;129:837–47.CrossRef Chug SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ, et al. Worldwide epidemiology of atrial fibrillation: a global burden of disease 2010 study. Circulation. 2014;129:837–47.CrossRef
5.
go back to reference Lowres N, Neubeck L, Redfern J, Freedman SB. Screening to identify unknown atrial fibrillation: a systematic review. Thromb Haemost. 2013;110:213–22.CrossRefPubMed Lowres N, Neubeck L, Redfern J, Freedman SB. Screening to identify unknown atrial fibrillation: a systematic review. Thromb Haemost. 2013;110:213–22.CrossRefPubMed
6.
go back to reference January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC, et al. 2014 AHA/ACC/HRS guideline for the management of atrial fibrillation. Circulation. 2014;130:e199–267.CrossRefPubMedPubMedCentral January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC, et al. 2014 AHA/ACC/HRS guideline for the management of atrial fibrillation. Circulation. 2014;130:e199–267.CrossRefPubMedPubMedCentral
7.
go back to reference Gage BF, Waterman AD, Shannon W, Boechler M, Rich MW, Rathford MJ. Validation of clinical classification schemes for predicting stroke: results from the national registry of atrial fibrillation. Jama. 2001;285(22):2864–70.CrossRefPubMed Gage BF, Waterman AD, Shannon W, Boechler M, Rich MW, Rathford MJ. Validation of clinical classification schemes for predicting stroke: results from the national registry of atrial fibrillation. Jama. 2001;285(22):2864–70.CrossRefPubMed
8.
go back to reference Caro JJ. An economic model of stroke in atrial fibrillation: the cost of suboptimal oral anticoagulation. Thromb Res. 2015;136(4):727–31.CrossRef Caro JJ. An economic model of stroke in atrial fibrillation: the cost of suboptimal oral anticoagulation. Thromb Res. 2015;136(4):727–31.CrossRef
9.
go back to reference Sindet-Peterson C, Pallisgaard JL, Olesen JB, Gislason GH, Arevalo LC. Safety and efficacy of direct oral anticoagulants compared to warfarin for extended treatment of venous thromboembolism-a systematic review and meta-analysis. Thromb Res. 2015;136(4):732–8.CrossRef Sindet-Peterson C, Pallisgaard JL, Olesen JB, Gislason GH, Arevalo LC. Safety and efficacy of direct oral anticoagulants compared to warfarin for extended treatment of venous thromboembolism-a systematic review and meta-analysis. Thromb Res. 2015;136(4):732–8.CrossRef
10.
go back to reference Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007;146(12):857–67.CrossRefPubMed Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007;146(12):857–67.CrossRefPubMed
11.
go back to reference Connolly SJ, Ezekowitz MB, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361:1139–51.CrossRefPubMed Connolly SJ, Ezekowitz MB, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361:1139–51.CrossRefPubMed
12.
go back to reference Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365:981–92.CrossRefPubMed Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365:981–92.CrossRefPubMed
13.
go back to reference Patel MR, Mahaffery KW, Garg J, Pan G, Singer DE, Hacke W, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365:883–91.CrossRefPubMed Patel MR, Mahaffery KW, Garg J, Pan G, Singer DE, Hacke W, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365:883–91.CrossRefPubMed
14.
go back to reference Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, et al. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2013;369(22):2093–104.CrossRefPubMed Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, et al. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2013;369(22):2093–104.CrossRefPubMed
15.
go back to reference Oktay E. Will NOACs become the new standard of care in anticoagulation therapy? Int J Cardiovasc Acad. 2015;1(1):1–4.CrossRef Oktay E. Will NOACs become the new standard of care in anticoagulation therapy? Int J Cardiovasc Acad. 2015;1(1):1–4.CrossRef
16.
17.
go back to reference DiMinno A, Spadarella G, Tufano A, Prisco D, Di Minno G. Ensuring medication adherence with direct oral anticoagulant drugs: lessons from adherence with vitamin K antagonists (VKAs). Thromb Res. 2014;133(5):699–704.CrossRef DiMinno A, Spadarella G, Tufano A, Prisco D, Di Minno G. Ensuring medication adherence with direct oral anticoagulant drugs: lessons from adherence with vitamin K antagonists (VKAs). Thromb Res. 2014;133(5):699–704.CrossRef
18.
go back to reference Ewen S, Rettig-Ewen V, Mahfoud F, Bohm M, Laufs U. Drug adherence in patients taking oral anticoagulation therapy. Clin Res Cardiol. 2014;103(3):173–82.CrossRefPubMed Ewen S, Rettig-Ewen V, Mahfoud F, Bohm M, Laufs U. Drug adherence in patients taking oral anticoagulation therapy. Clin Res Cardiol. 2014;103(3):173–82.CrossRefPubMed
19.
go back to reference Gladstone DJ, Geerts WH, Douketis J, Ivers N, Healey JS, Leblanc K. Anticoagulant monitoring checklist and quick-reference tables for managing patients on direct oral anticoagulants (DOACs) for stroke prevention in atrial fibrillation. Thromb Can. 2015;163(5):382–5. Gladstone DJ, Geerts WH, Douketis J, Ivers N, Healey JS, Leblanc K. Anticoagulant monitoring checklist and quick-reference tables for managing patients on direct oral anticoagulants (DOACs) for stroke prevention in atrial fibrillation. Thromb Can. 2015;163(5):382–5.
20.
go back to reference Shore S, Carey EP, Turakhia MP, Jackevicius CA, Cunningham F, Pilote L, et al. Adherence to dabigatran therapy and longitudinal patient outcomes: insights from the veterans health administration. Am Heart J. 2014;167(6):810–7.CrossRefPubMedPubMedCentral Shore S, Carey EP, Turakhia MP, Jackevicius CA, Cunningham F, Pilote L, et al. Adherence to dabigatran therapy and longitudinal patient outcomes: insights from the veterans health administration. Am Heart J. 2014;167(6):810–7.CrossRefPubMedPubMedCentral
21.
go back to reference Gupta V, Kogut SJ, Thompson S. Evaluation of differences in percentage of international normalized ratios in range between pharmacist-led and physician-led anticoagulation management services. J Pharm Pract. 2015;28(3):249–55.CrossRefPubMed Gupta V, Kogut SJ, Thompson S. Evaluation of differences in percentage of international normalized ratios in range between pharmacist-led and physician-led anticoagulation management services. J Pharm Pract. 2015;28(3):249–55.CrossRefPubMed
22.
go back to reference Collins S, Barber A, Sahm LJ. Pharmacist’s counselling improves patient knowledge regarding warfarin, irrespective of health literacy level. Pharmacy. 2014;2(1):114–23.CrossRef Collins S, Barber A, Sahm LJ. Pharmacist’s counselling improves patient knowledge regarding warfarin, irrespective of health literacy level. Pharmacy. 2014;2(1):114–23.CrossRef
23.
go back to reference Rudd KM, Dier JG. Comparison of two different models of anticoagulation management services with usual medical care. Pharmacotherapy. 2010;30(4):330–8.CrossRefPubMed Rudd KM, Dier JG. Comparison of two different models of anticoagulation management services with usual medical care. Pharmacotherapy. 2010;30(4):330–8.CrossRefPubMed
24.
go back to reference Castelluci LA, Shaw J, van der Salm K, Erkens P, Le Gal G, Petrcich W, et al. Self-reported adherence to anticoagulation and its determinants using the Morisky medication adherence scale. Thromb Res. 2015;136(4):727–31.CrossRef Castelluci LA, Shaw J, van der Salm K, Erkens P, Le Gal G, Petrcich W, et al. Self-reported adherence to anticoagulation and its determinants using the Morisky medication adherence scale. Thromb Res. 2015;136(4):727–31.CrossRef
25.
go back to reference McCullough KB, Formea CM, Berg KD, Burzynski JA, Cunnigham JL, Ou NN, et al. Assessment of the pharmacogenomics educational needs of pharmacists. Am J Pharm Educ. 2011;75(3):51.CrossRefPubMedPubMedCentral McCullough KB, Formea CM, Berg KD, Burzynski JA, Cunnigham JL, Ou NN, et al. Assessment of the pharmacogenomics educational needs of pharmacists. Am J Pharm Educ. 2011;75(3):51.CrossRefPubMedPubMedCentral
26.
go back to reference Lemmens-Gruber R, Hahnenkamp C, Gossmann U, Harreiter J, Kamyar MR, Johnson BJ, et al. Evaluation of educational needs in patients with diabetes mellitus in respect of medication use in Austria. Int J Clin Pharm. 2012;34(3):490–500.CrossRefPubMed Lemmens-Gruber R, Hahnenkamp C, Gossmann U, Harreiter J, Kamyar MR, Johnson BJ, et al. Evaluation of educational needs in patients with diabetes mellitus in respect of medication use in Austria. Int J Clin Pharm. 2012;34(3):490–500.CrossRefPubMed
27.
go back to reference Budnitz DS, Lovegrove MC, Shehab N, Richards CL. Emergency hospitalizations for adverse drug events in older Americans. N Engl J Med. 2011;365(21):2002–12.CrossRefPubMed Budnitz DS, Lovegrove MC, Shehab N, Richards CL. Emergency hospitalizations for adverse drug events in older Americans. N Engl J Med. 2011;365(21):2002–12.CrossRefPubMed
28.
go back to reference Elewa H, Alhaddad A, Al-Rawi S, Nounou A, Mahmoud H, Singh R. Trends in oral anticoagulant use in Qatar: a 5-year experience. J Thromb Thrombolysis. 2017;43(3):411–6.CrossRefPubMed Elewa H, Alhaddad A, Al-Rawi S, Nounou A, Mahmoud H, Singh R. Trends in oral anticoagulant use in Qatar: a 5-year experience. J Thromb Thrombolysis. 2017;43(3):411–6.CrossRefPubMed
29.
go back to reference Guyatt GH, Akl EA, Crowther M, Gutterman DD, Schuunemann HJ. Executive summary: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2012;2(Suppl):7S–47S.CrossRef Guyatt GH, Akl EA, Crowther M, Gutterman DD, Schuunemann HJ. Executive summary: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2012;2(Suppl):7S–47S.CrossRef
30.
go back to reference Cross CTT. Continuing Professional Development/Continuing Education in Pharmacy: Global Report. The Hague: International Pharmaceutical Federation; 2014. Cross CTT. Continuing Professional Development/Continuing Education in Pharmacy: Global Report. The Hague: International Pharmaceutical Federation; 2014.
31.
go back to reference Prot-Labarthe S, Stil-Baudry J, Fahd M, Brion F, Bourdon O. The role of community pharmacists in the management of hematopoietic stem cell transplant recipients: knowledge and training. J Pediatr Hematol Oncol. 2013;35(3):188–92.CrossRefPubMed Prot-Labarthe S, Stil-Baudry J, Fahd M, Brion F, Bourdon O. The role of community pharmacists in the management of hematopoietic stem cell transplant recipients: knowledge and training. J Pediatr Hematol Oncol. 2013;35(3):188–92.CrossRefPubMed
32.
go back to reference Bascom CS, Rosenthal MM, Houle SK. Are pharmacists ready for a greater role in travel health? An evaluation of the knowledge and confidence in providing travel health advice of pharmacists practicing in a community pharmacy chain in Alberta, Canada. J Travel Med. 2015;22(2):99–104.CrossRefPubMed Bascom CS, Rosenthal MM, Houle SK. Are pharmacists ready for a greater role in travel health? An evaluation of the knowledge and confidence in providing travel health advice of pharmacists practicing in a community pharmacy chain in Alberta, Canada. J Travel Med. 2015;22(2):99–104.CrossRefPubMed
33.
go back to reference Taing MW, Tan ET, Williams GM, Clavarino AM, McGuire TM. Herbal and nutrient complementary medicines for weight loss: community pharmacists’ practices, attitudes, recommendations, information and education needs. Int J Pharm Pract. 2016;24(3):160–9.CrossRefPubMed Taing MW, Tan ET, Williams GM, Clavarino AM, McGuire TM. Herbal and nutrient complementary medicines for weight loss: community pharmacists’ practices, attitudes, recommendations, information and education needs. Int J Pharm Pract. 2016;24(3):160–9.CrossRefPubMed
34.
go back to reference Al-Saleh H, Al-Houtan T, Al-Odaill K, Al-Mutairi B, Al-Muaybid M, Al-Falah T, et al. Role of community pharmacists in providing oral health advice in the Eastern province of Saudi Arabia. Saudi Dent J. 2017;29(3):123–8.CrossRefPubMedPubMedCentral Al-Saleh H, Al-Houtan T, Al-Odaill K, Al-Mutairi B, Al-Muaybid M, Al-Falah T, et al. Role of community pharmacists in providing oral health advice in the Eastern province of Saudi Arabia. Saudi Dent J. 2017;29(3):123–8.CrossRefPubMedPubMedCentral
35.
go back to reference Kheir N, Zaidan M, Younes H, El Hajj M, Wilbur K, Jewesson PJ. Pharmacy education and practice in 13 Middle Eastern countries. Am J Pharm Educ. 2008;72(6):133.CrossRefPubMedPubMedCentral Kheir N, Zaidan M, Younes H, El Hajj M, Wilbur K, Jewesson PJ. Pharmacy education and practice in 13 Middle Eastern countries. Am J Pharm Educ. 2008;72(6):133.CrossRefPubMedPubMedCentral
Metadata
Title
Pharmacists’ confidence when providing pharmaceutical care on anticoagulants, a multinational survey
Authors
John Papastergiou
Nadir Kheir
Katerina Ladova
Silas Rydant
Fabio De Rango
Sotiris Antoniou
Reka Viola
Maria Dolores Murillo
Stephane Steurbaut
Filipa Alves da Costa
Publication date
01-12-2017
Publisher
Springer International Publishing
Published in
International Journal of Clinical Pharmacy / Issue 6/2017
Print ISSN: 2210-7703
Electronic ISSN: 2210-7711
DOI
https://doi.org/10.1007/s11096-017-0551-2

Other articles of this Issue 6/2017

International Journal of Clinical Pharmacy 6/2017 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.