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01-05-2020 | Radiotherapy | Clinical Study

Effect of early radiotherapy initiation and high-dose chemotherapy on the prognosis of pediatric atypical teratoid rhabdoid tumors in different age groups

Authors: Wan-Chin Yang, Hsiu-Ju Yen, Muh-Lii Liang, Hsin-Hung Chen, Yi-Yen Lee, Feng-Chi Chang, Shih-Chieh Lin, Tai-Tong Wong, Yu-Wen Hu, Yi-Wei Chen

Published in: Journal of Neuro-Oncology | Issue 3/2020

Abstract

Purpose

The optimal treatment strategy for pediatric atypical teratoid rhabdoid tumor (ATRT) is inconclusive. This study evaluated the prognostic value of early radiotherapy (RT) and high-dose chemotherapy with autologous stem cell rescue (HDC/ASCR) in pediatric ATRT.

Methods

This pooled analysis included ATRT patients treated at our institution and from other studies who were identified by a search of the PubMed electronic database. The effect of patient demographics and treatment profiles on progression-free survival (PFS) and overall survival (OS) were analyzed using Cox regression.

Results

Overall, 34 patients from our institution and 436 patients from 35 published studies were included. In multivariable analysis, patients with gross total resection (GTR), early RT (time to RT interval < 2 months), and HDC/ASCR had both better PFS [hazard ratio (HR) 0.46, p\(<\) 0.001; HR 0.64, p = 0.011; and HR 0.51, p = 0.005, respectively] and OS (HR 0.55, p = 0.002; HR 0.48, p = 0.004; and HR 0.42, p < 0.001, respectively). For patients aged < 3 years, both RT and HDC/ASCR were significant favorable factors for PFS (HR 0.32 and 0.46, respectively) and OS (HR 0.40 and 0.36, respectively), while early RT was not prognostic. For patients aged ≥ 3 years, early RT was significantly associated with better PFS (HR 0.51) and HDC/ASCR did not affect PFS, and neither was related to OS.

Conclusion

Both early RT initiation and HDC/ASCR were important components in the treatment of pediatric ATRT. However, the optimal treatment strategies might differ by age.

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Ostrom QT, de Blank PM, Kruchko C, Petersen CM, Liao P, Finlay JL, Stearns DS, Wolff JE, Wolinsky Y, Letterio JJ, Barnholtz-Sloan JS (2015) Alex's lemonade stand foundation infant and childhood primary brain and central nervous system tumors diagnosed in the United States in 2007–2011. Neuro Oncol 16(Suppl 10):x1–x36. https://doi.org/10.1093/neuonc/nou327 CrossRefPubMed

Hilden JM, Meerbaum S, Burger P, Finlay J, Janss A, Scheithauer BW, Walter AW, Rorke LB, Biegel JA (2004) Central nervous system atypical teratoid/rhabdoid tumor: results of therapy in children enrolled in a registry. J Clin Oncol 22:2877–2884. https://doi.org/10.1200/jco.2004.07.073 CrossRefPubMed

Lafay-Cousin L, Hawkins C, Carret AS, Johnston D, Zelcer S, Wilson B, Jabado N, Scheinemann K, Eisenstat D, Fryer C, Fleming A, Mpofu C, Larouche V, Strother D, Bouffet E, Huang A (2012) Central nervous system atypical teratoid rhabdoid tumours: the Canadian Paediatric Brain Tumour Consortium experience. Eur J Cancer (Oxford, England: 1990) 48:353–359. https://doi.org/10.1016/j.ejca.2011.09.005 CrossRef

Benesch M, Bartelheim K, Fleischhack G, Gruhn B, Schlegel PG, Witt O, Stachel KD, Hauch H, Urban C, Quehenberger F, Massimino M, Pietsch T, Hasselblatt M, Giangaspero F, Kordes U, Schneppenheim R, Hauser P, Klingebiel T, Fruhwald MC (2014) High-dose chemotherapy (HDCT) with auto-SCT in children with atypical teratoid/rhabdoid tumors (AT/RT): a report from the European Rhabdoid Registry (EU-RHAB). Bone Marrow Transpl 49:370–375. https://doi.org/10.1038/bmt.2013.208 CrossRef

Reddy A, Strother D, Judkins A, Krailo M, Gao Y, Douglas J, Mahajan A, Lewis V, Mazewski C, Laningham F, Pollack I, Gajjar A, Biegel J (2016) At-09treatment of Atypical Teratoid Rhabdoid Tumors (Atrt) of the central nervous system with surgery, intensive chemotherapy, and 3-D Conformal Radiation (Acns0333). A Report from the Children's Oncology Group. Neuro-Oncology 18:iii2. https://doi.org/10.1093/neuonc/now065.08 CrossRefPubMedCentral

ClinicalTrials.gov Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors (SJATRT)

Athale UH, Duckworth J, Odame I, Barr R (2009) Childhood atypical teratoid rhabdoid tumor of the central nervous system: a meta-analysis of observational studies. J Pediatr Hematol Oncol 31:651–663. https://doi.org/10.1097/MPH.0b013e3181b258a9 CrossRefPubMed

Schrey D, Carceller Lechon F, Malietzis G, Moreno L, Dufour C, Chi S, Lafay-Cousin L, von Hoff K, Athanasiou T, Marshall LV, Zacharoulis S (2016) Multimodal therapy in children and adolescents with newly diagnosed atypical teratoid rhabdoid tumor: individual pooled data analysis and review of the literature. J Neuro-oncol 126:81–90. https://doi.org/10.1007/s11060-015-1904-0 CrossRef

Fossey M, Li H, Afzal S, Carret AS, Eisenstat DD, Fleming A, Hukin J, Hawkins C, Jabado N, Johnston D, Brown T, Larouche V, Scheinemann K, Strother D, Wilson B, Zelcer S, Huang A, Bouffet E, Lafay-Cousin L (2017) Atypical teratoid rhabdoid tumor in the first year of life: the Canadian ATRT registry experience and review of the literature. J Neuro-oncol 132:155–162. https://doi.org/10.1007/s11060-016-2353-0 CrossRef

10.

Pai Panandiker AS, Merchant TE, Beltran C, Wu S, Sharma S, Boop FA, Jenkins JJ, Helton KJ, Wright KD, Broniscer A, Kun LE, Gajjar A (2012) Sequencing of local therapy affects the pattern of treatment failure and survival in children with atypical teratoid rhabdoid tumors of the central nervous system. Int J Radiat Oncol Biol Phys 82:1756–1763. https://doi.org/10.1016/j.ijrobp.2011.02.059 CrossRefPubMed

11.

Lee J, Kim DS, Han JW, Suh CO (2017) Atypical teratoid/rhabdoid tumors in children treated with multimodal therapies: the necessity of upfront radiotherapy after surgery. Pediatr Blood Cancer 64:e26663. https://doi.org/10.1002/pbc.26663 CrossRef

12.

Fruhwald MC, Hasselblatt M, Nemes K, Bens S, Steinbugl M, Johann PD, Kerl K, Hauser P, Quiroga E, Solano-Paez P, Biassoni V, Gil-da-Costa MJ, Perek-Polnik M, van de Wetering M, Sumerauer D, Pears J, Stabell N, Holm S, Hengartner H, Gerber NU, Grotzer M, Boos J, Ebinger M, Tippelt S, Paulus W, Furtwangler R, Hernaiz-Driever P, Reinhard H, Rutkowski S, Schlegel PG, Schmid I, Kortmann RD, Timmermann B, Warmuth-Metz M, Kordes U, Gerss J, Nysom K, Schneppenheim R, Siebert R, Kool M, Graf N (2019) Age and DNA-methylation subgroup as potential independent risk factors for treatment stratification in children with Atypical Teratoid/Rhabdoid Tumors (ATRT). Neuro Oncol. https://doi.org/10.1093/neuonc/noz244 CrossRefPubMedCentral

13.

Johann PD, Erkek S, Zapatka M, Kerl K, Buchhalter I, Hovestadt V, Jones DTW, Sturm D, Hermann C, Segura Wang M, Korshunov A, Rhyzova M, Grobner S, Brabetz S, Chavez L, Bens S, Groschel S, Kratochwil F, Wittmann A, Sieber L, Georg C, Wolf S, Beck K, Oyen F, Capper D, van Sluis P, Volckmann R, Koster J, Versteeg R, von Deimling A, Milde T, Witt O, Kulozik AE, Ebinger M, Shalaby T, Grotzer M, Sumerauer D, Zamecnik J, Mora J, Jabado N, Taylor MD, Huang A, Aronica E, Bertoni A, Radlwimmer B, Pietsch T, Schuller U, Schneppenheim R, Northcott PA, Korbel JO, Siebert R, Fruhwald MC, Lichter P, Eils R, Gajjar A, Hasselblatt M, Pfister SM, Kool M (2016) Atypical Teratoid/Rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes. Cancer Cell 29:379–393. https://doi.org/10.1016/j.ccell.2016.02.001 CrossRefPubMed

14.

Torchia J, Picard D, Lafay-Cousin L, Hawkins CE, Kim S-K, Letourneau L, Ra Y-S, Ho KC, Chan TSY, Sin-Chan P, Dunham CP, Yip S, Ng H-k, Lu J-Q, Albrecht S, Pimentel J, Chan JA, Somers GR, Zielenska M, Faria CC, Roque L, Baskin B, Birks D, Foreman N, Strother D, Klekner A, Garami M, Hauser P, Hortobágyi T, Bognár L, Wilson B, Hukin J, Carret A-S, Van Meter TE, Nakamura H, Toledano H, Fried I, Fults D, Wataya T, Fryer C, Eisenstat DD, Scheineman K, Johnston D, Michaud J, Zelcer S, Hammond R, Ramsay DA, Fleming AJ, Lulla RR, Fangusaro JR, Sirachainan N, Larbcharoensub N, Hongeng S, Barakzai MA, Montpetit A, Stephens D, Grundy RG, Schüller U, Nicolaides T, Tihan T, Phillips J, Taylor MD, Rutka JT, Dirks P, Bader GD, Warmuth-Metz M, Rutkowski S, Pietsch T, Judkins AR, Jabado N, Bouffet E, Huang A (2015) Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis. Lancet Oncol 16:569–582. https://doi.org/10.1016/S1470-2045(15)70114-2 CrossRefPubMed

15.

Bartelheim K, Nemes K, Seeringer A, Kerl K, Buechner J, Boos J, Graf N, Durken M, Gerss J, Hasselblatt M, Kortmann RD, Teichert von Luettichau I, Nagel I, Nygaard R, Oyen F, Quiroga E, Schlegel PG, Schmid I, Schneppenheim R, Siebert R, Solano-Paez P, Timmermann B, Warmuth-Metz M, Fruhwald MC (2016) Improved 6-year overall survival in AT/RT: results of the registry study Rhabdoid 2007. Cancer Med 5:1765–1775. https://doi.org/10.1002/cam4.741 CrossRefPubMedPubMedCentral

16.

Poynter JN, Fonstad R, Tolar J, Spector LG, Ross JA (2014) Incidence of intracranial germ cell tumors by race in the United States, 1992–2010. J Neurooncol 120:381–388. https://doi.org/10.1007/s11060-014-1562-7 CrossRefPubMedPubMedCentral

17.

Goodwin TL, Sainani K, Fisher PG (2009) Incidence patterns of central nervous system germ cell tumors: a SEER Study. J Pediatr Hematol Oncol 31:541–544. https://doi.org/10.1097/MPH.0b013e3181983af5 CrossRefPubMed

18.

Chen YW, Wong TT, Ho DM, Huang PI, Chang KP, Shiau CY, Yen SH (2006) Impact of radiotherapy for pediatric CNS atypical teratoid/rhabdoid tumor (single institute experience). Int J Radiat Oncol Biol Phys 64:1038–1043. https://doi.org/10.1016/j.ijrobp.2005.10.001 CrossRefPubMed

19.

Yang W-C, Yen H-J, Liang M-L, Chen H-H, Lee Y-Y, Wong T-T, Hu Y-W, Chen Y-W (2019) Role of early and aggressive post-operative radiation therapy in improving outcome for pediatric central nervous system atypical teratoid/rhabdoid tumor. Child's Nerv Syst. https://doi.org/10.1007/s00381-019-04126-y CrossRef

20.

Spearman Rank Correlation. Encyclopedia of Biostatistics

21.

Therneau TM, Lumley T (2014) Package ‘survival’. Survival analysis Published on CRAN

22.

Suissa S (2008) Immortal time bias in pharmacoepidemiology. Am J Epidemiol 167:492–499. https://doi.org/10.1093/aje/kwm324 CrossRefPubMed

23.

Dafni U (2011) Landmark analysis at the 25-year landmark point. Circul Cardiovasc Qual Outcomes 4:363–371. https://doi.org/10.1161/circoutcomes.110.957951 CrossRef

24.

Zaky W, Dhall G, Ji L, Haley K, Allen J, Atlas M, Bertolone S, Cornelius A, Gardner S, Patel R, Pradhan K, Shen V, Thompson S, Torkildson J, Sposto R, Finlay JL (2014) Intensive induction chemotherapy followed by myeloablative chemotherapy with autologous hematopoietic progenitor cell rescue for young children newly-diagnosed with central nervous system atypical teratoid/rhabdoid tumors: the Head Start III experience. Pediatr Blood Cancer 61:95–101. https://doi.org/10.1002/pbc.24648 CrossRefPubMed

25.

Slavc I, Chocholous M, Leiss U, Haberler C, Peyrl A, Azizi AA, Dieckmann K, Woehrer A, Peters C, Widhalm G, Dorfer C, Czech T (2014) Atypical teratoid rhabdoid tumor: improved long-term survival with an intensive multimodal therapy and delayed radiotherapy. The Medical University of Vienna Experience 1992–2012. Cancer Med 3:91–100. https://doi.org/10.1002/cam4.161 CrossRefPubMed

26.

Sung KW, Lim DH, Yi ES, Choi YB, Lee JW, Yoo KH, Koo HH, Kim JH, Suh YL, Joung YS, Shin HJ (2016) tandem high-dose chemotherapy and autologous stem cell transplantation for atypical teratoid/rhabdoid tumor. Cancer Res Treat 48:1408–1419. https://doi.org/10.4143/crt.2015.347 CrossRefPubMedPubMedCentral

27.

Ng'andu NH (1997) An empirical comparison of statistical tests for assessing the proportional hazards assumption of cox's model. Stat Med 16:611–626. https://doi.org/10.1002/(sici)1097-0258(19970330)16:6%3c611:aid-sim437%3e3.0.co;2-t CrossRefPubMed

28.

Al-Hussaini M, Swaidan M, Al-Jumaily U, Musharbash A (2013) Central nervous system tumors in the first year of life: a clinical and pathologic experience from a single cancer center. Child's Nerv Syst 29:1883–1891. https://doi.org/10.1007/s00381-013-2081-0 CrossRef

29.

Al-Hussaini M, Dissi N, Souki C, Amayiri N (2016) Atypical teratoid/ rhabdoid tumor, an immunohistochemical study of potential diagnostic and prognostic markers. Neuropathology 36:17–26. https://doi.org/10.1111/neup.12231 CrossRefPubMed

30.

Finkelstein-Shechter T, Gassas A, Mabbott D, Huang A, Bartels U, Tabori U, Janzen L, Hawkins C, Taylor M, Bouffet E (2010) Atypical teratoid or rhabdoid tumors: improved outcome with high-dose chemotherapy. J Pediatr Hematol Oncol 32:e182–186. https://doi.org/10.1097/MPH.0b013e3181dce1a2 CrossRefPubMed

31.

Lafay-Cousin L, Fay-McClymont T, Johnston D, Fryer C, Scheinemann K, Fleming A, Hukin J, Janzen L, Guger S, Strother D, Mabbott D, Huang A, Bouffet E (2015) Neurocognitive evaluation of long term survivors of atypical teratoid rhabdoid tumors (ATRT): The Canadian Registry experience. Pediatr Blood Cancer 62:1265–1269. https://doi.org/10.1002/pbc.25441 CrossRefPubMed

32.

Chi SN, Zimmerman MA, Yao X, Cohen KJ, Burger P, Biegel JA, Rorke-Adams LB, Fisher MJ, Janss A, Mazewski C, Goldman S, Manley PE, Bowers DC, Bendel A, Rubin J, Turner CD, Marcus KJ, Goumnerova L, Ullrich NJ, Kieran MW (2009) Intensive multimodality treatment for children with newly diagnosed CNS atypical teratoid rhabdoid tumor. J Clin Oncol 27:385–389. https://doi.org/10.1200/jco.2008.18.7724 CrossRefPubMedPubMedCentral

33.

Fidani P, De Ioris MA, Serra A, De Sio L, Ilari I, Cozza R, Boldrini R, Milano GM, Garre ML, Donfrancesco A (2009) A multimodal strategy based on surgery, radiotherapy, ICE regimen and high dose chemotherapy in atypical teratoid/rhabdoid tumours: a single institution experience. J Neuro-oncol 92:177–183. https://doi.org/10.1007/s11060-008-9750-y CrossRef

34.

Appaji L, Aruna Kumari BS, Babu KG, Premalata CS, Pramod KPR, Bhat GR, Prem C (2017) Atypical teratoid rhabdoid tumor of the central nervous system: case series from a regional Tertiary Care Cancer Centre in South India. J Cancer Res Ther 13:1015–1022. https://doi.org/10.4103/0973-1482.174536 CrossRefPubMed

35.

Uwineza A, Gill H, Buckley P, Owens C, Capra M, O'Sullivan C, McDermott M, Brett F, Farrell M, Pears J, O'Sullivan MJ (2014) Rhabdoid tumor: the Irish experience 1986–2013. Cancer Genet 207:398–402. https://doi.org/10.1016/j.cancergen.2014.05.015 CrossRefPubMed

36.

Odagiri K, Omura M, Hata M, Aida N, Niwa T, Goto H, Ito S, Adachi M, Yoshida H, Yuki H, Inoue T (2014) Treatment outcomes and late toxicities in patients with embryonal central nervous system tumors. Radiat Oncol (London, England) 9:201. https://doi.org/10.1186/1748-717X-9-201 CrossRef

37.

Park ES, Sung KW, Baek HJ, Park KD, Park HJ, Won SC, Lim DH, Kim HS (2012) Tandem high-dose chemotherapy and autologous stem cell transplantation in young children with atypical teratoid/rhabdoid tumor of the central nervous system. J Korean Med Sci 27:135–140. https://doi.org/10.3346/jkms.2012.27.2.135 CrossRefPubMedPubMedCentral

38.

Guerra JA, Dhall G, Marachelian A, Castillo E, Malvar J, Wong K, Sposto R, Finlay JL (2017) Marrow-ablative chemotherapy followed by tandem autologous hematopoietic cell transplantation in pediatric patients with malignant brain tumors. Bone Marrow Transpl 52:1543–1548. https://doi.org/10.1038/bmt.2017.166 CrossRef

39.

De Amorim BK, Sethi R, Trofimov A, Zeng C, Fullerton B, Yeap BY, Ebb D, Tarbell NJ, Yock TI, MacDonald SM (2013) Early clinical outcomes using proton radiation for children with central nervous system atypical teratoid rhabdoid tumors. Int J Radiat Oncol Biol Phys 86:114–120. https://doi.org/10.1016/j.ijrobp.2012.12.004 CrossRef

40.

McGovern SL, Okcu MF, Munsell MF, Kumbalasseriyil N, Grosshans D, McAleer MF, Chintagumpala M, Khatua S, Mahajan A (2014) Outcomes and acute toxicities of proton therapy for pediatric atypical teratoid/rhabdoid tumor of the CNS. Int J Radiat Oncol Biol Phys 90:1143–1152. https://doi.org/10.1016/j.ijrobp.2014.08.354 CrossRefPubMedPubMedCentral

41.

de León-Bojorge B, Rueda-Franco F, Anaya-Jara M (2008) Central nervous system atypical teratoid rhabdoid tumor: experience at the National Institute of Pediatrics, Mexico City. Child's Nerv Syst 24:307–312. https://doi.org/10.1007/s00381-007-0464-9 CrossRef

42.

Alsultan A, Alharbi M, Al-Dandan S, Bayoumi Y, Alharbi T, Alsudairy R, Alomari A, Aljamaan K, Musleh O, Alharbi Q, Jarrar M (2015) High-dose chemotherapy with autologous stem cell rescue in saudi children less than 3 years of age with embryonal brain tumors. J Pediatr Hematol Oncol 37:204–208. https://doi.org/10.1097/mph.0000000000000301 CrossRefPubMed

43.

Lee JY, Kim I-K, Phi JH, Wang K-C, Cho B-K, Park S-H, Ahn HS, Kim IH, Kim S-K (2012) Atypical teratoid/rhabdoid tumors: the need for more active therapeutic measures in younger patients. J Neuro-oncol 107:413–419. https://doi.org/10.1007/s11060-011-0769-0 CrossRef

44.

Wang RF, Guan WB, Yan Y, Jiang B, Ma J, Jiang MW, Wang LF (2016) Atypical teratoid/rhabdoid tumours: clinicopathological characteristics, prognostic factors and outcomes of 22 children from 2010 to 2015 in China. Pathology 48:555–563. https://doi.org/10.1016/j.pathol.2016.05.010 CrossRefPubMed

45.

Tekautz TM, Fuller CE, Blaney S, Fouladi M, Broniscer A, Merchant TE, Krasin M, Dalton J, Hale G, Kun LE, Wallace D, Gilbertson RJ, Gajjar A (2005) Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy. J Clin Oncol 23:1491–1499. https://doi.org/10.1200/jco.2005.05.187 CrossRefPubMed

46.

Ertan Y, Sezak M, Turhan T, Kantar M, Ersahin Y, Mutluer S, Vergin C, Oniz H, Akalin T (2009) Atypical teratoid/rhabdoid tumor of the central nervous system: clinicopathologic and immunohistochemical features of four cases. Child's Nerv Syst 25:707–711. https://doi.org/10.1007/s00381-009-0811-0 CrossRef

47.

Nicolaides T, Tihan T, Horn B, Biegel J, Prados M, Banerjee A (2010) High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system. J Neuro-oncol 98:117–123. https://doi.org/10.1007/s11060-009-0071-6 CrossRef

48.

Verma V, Johnson CP, Bennion NR, Bhirud AR, Li S, McComb RD, Lin C (2015) Atypical teratoid rhabdoid tumor: long-term survival after chemoradiotherapy. Child's Nerv Syst 31:1393–1399. https://doi.org/10.1007/s00381-015-2723-5 CrossRef

49.

Woehrer A, Slavc I, Waldhoer T, Heinzl H, Zielonke N, Czech T, Benesch M, Hainfellner JA, Haberler C (2010) Incidence of atypical teratoid/rhabdoid tumors in children: a population-based study by the Austrian Brain Tumor Registry, 1996–2006. Cancer 116:5725–5732. https://doi.org/10.1002/cncr.25540 CrossRefPubMed

50.

Weber DC, Ares C, Malyapa R, Albertini F, Calaminus G, Kliebsch U, Mikroutsikos L, Morach P, Bolsi A, Lomax T, Schneider R (2015) Tumor control and QoL outcomes of very young children with atypical teratoid/rhabdoid tumor treated with focal only chemo-radiation therapy using pencil beam scanning proton therapy. J Neuro-oncol 121:389–397. https://doi.org/10.1007/s11060-014-1648-2 CrossRef

51.

DiPatri AJ Jr, Sredni ST, Grahovac G, Tomita T (2015) Atypical teratoid rhabdoid tumors of the posterior fossa in children. Child's Nerv Syst 31:1717–1728. https://doi.org/10.1007/s00381-015-2844-x CrossRef

52.

Biswas A, Goyal S, Puri T, Das P, Sarkar C, Julka PK, Bakhshi S, Rath GK (2009) Atypical teratoid rhabdoid tumor of the brain: case series and review of literature. Child's Nerv Syst 25:1495–1500. https://doi.org/10.1007/s00381-009-0903-x CrossRef

53.

Yang M, Chen X, Wang N, Zhu K, Hu YZ, Zhao Y, Shu Y, Zhao ML, Gu WZ, Tang HF (2014) Primary atypical teratoid/rhabdoid tumor of central nervous system in children: a clinicopathological analysis and review of literature in China. Int J Clin Exp Pathol 7:2411–2420PubMedPubMedCentral

54.

Buscariollo DL, Park HS, Roberts KB, Yu JB (2012) Survival outcomes in atypical teratoid rhabdoid tumor for patients undergoing radiotherapy in a surveillance, epidemiology, and end results analysis. Cancer 118:4212–4219. https://doi.org/10.1002/cncr.27373 CrossRefPubMed

55.

Bourdeaut F, Lequin D, Brugieres L, Reynaud S, Dufour C, Doz F, Andre N, Stephan JL, Perel Y, Oberlin O, Orbach D, Bergeron C, Rialland X, Freneaux P, Ranchere D, Figarella-Branger D, Audry G, Puget S, Evans DG, Pinas JC, Capra V, Mosseri V, Coupier I, Gauthier-Villars M, Pierron G, Delattre O (2011) Frequent hSNF5/INI1 germline mutations in patients with rhabdoid tumor. Clin Cancer Res 17:31–38. https://doi.org/10.1158/1078-0432.ccr-10-1795 CrossRefPubMed

56.

Sredni ST, Tomita T (2015) Rhabdoid tumor predisposition syndrome. Pediatr Dev Pathol 18:49–58. https://doi.org/10.2350/14-07-1531-MISC.1 CrossRefPubMed

57.

Holsten T, Bens S, Oyen F, Nemes K, Hasselblatt M, Kordes U, Siebert R, Fruhwald MC, Schneppenheim R, Schuller U (2018) Germline variants in SMARCB1 and other members of the BAF chromatin-remodeling complex across human disease entities: a meta-analysis. Eur J Hum Genet 26:1083–1093. https://doi.org/10.1038/s41431-018-0143-1 CrossRefPubMedPubMedCentral

58.

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131:803–820. https://doi.org/10.1007/s00401-016-1545-1 CrossRefPubMed

Title: Effect of early radiotherapy initiation and high-dose chemotherapy on the prognosis of pediatric atypical teratoid rhabdoid tumors in different age groups
Authors: Wan-Chin Yang
Hsiu-Ju Yen
Muh-Lii Liang
Hsin-Hung Chen
Yi-Yen Lee
Feng-Chi Chang
Shih-Chieh Lin
Tai-Tong Wong
Yu-Wen Hu
Yi-Wei Chen
Publication date: 01-05-2020
Publisher: Springer US
Keywords: Radiotherapy
Cytostatic Therapy
Published in: Journal of Neuro-Oncology / Issue 3/2020
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-020-03456-1

At a glance: The STEP trials

Springer Medicine

Effect of early radiotherapy initiation and high-dose chemotherapy on the prognosis of pediatric atypical teratoid rhabdoid tumors in different age groups

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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