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Journal of Neuro-Oncology
Published in: Journal of Neuro-Oncology 3/2020

01-12-2020 | Mucosal Melanoma | Clinical Study

Outcomes of sinonasal mucosal melanomas with endoscopic and open resection: a retrospective cohort study

Authors: Deema M. Almutuawa, Madeleine P. Strohl, Calvin Gruss, Annemieke van Zante, Sue S. Yom, Michael W. McDermott, Ivan H. El-Sayed

Published in: Journal of Neuro-Oncology | Issue 3/2020

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Abstract

Purpose

To compare the outcomes of Sinonasal Mucosal Melanomas (SNMM) treated with endoscopic and open resection.

Methods

A retrospective case review of 20 patients with SNMM treated surgically at UCSF. Kaplan–Meier analyses were calculated to determine outcome differences in endoscopic vs. open resections.

Results

From 2005 to 2014, 20 cases of SNMM were confirmed and treated at UCSF. All cases underwent surgical resection, with 10 cases by open resection and 10 cases by endoscopic resection. Using Kaplan–Meier analyses, the open resection group had a 1-year survival of 30% whereas endoscopic resection group was 80% (p = 0.032). Endoscopic resection showed improved survival at all time points after surgery compared to open resection.

Conclusion

SNMM is a rare and aggressive tumor that is associated with low survival rates. In this small case series, endoscopic resection had improved survival outcomes compared to open resection.
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Metadata
Title
Outcomes of sinonasal mucosal melanomas with endoscopic and open resection: a retrospective cohort study
Authors
Deema M. Almutuawa
Madeleine P. Strohl
Calvin Gruss
Annemieke van Zante
Sue S. Yom
Michael W. McDermott
Ivan H. El-Sayed
Publication date
01-12-2020
Publisher
Springer US
Published in
Journal of Neuro-Oncology / Issue 3/2020
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI
https://doi.org/10.1007/s11060-020-03449-0

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