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01-07-2017 | Topic Review

The role of bevacizumab in the treatment of glioblastoma

Authors: Roberto Jose Diaz, Sheikh Ali, Mehreen Gull Qadir, Macarena I. De La Fuente, Michael E. Ivan, Ricardo J. Komotar

Published in: Journal of Neuro-Oncology | Issue 3/2017

Abstract

Bevacizumab has been used in patients with GBM as a salvage therapy since its approval in the United States for recurrent GBM in 2009. In order to review the therapeutic effect of bevacizumab in the primary and recurrent clinical setting we have performed a systematic analysis of data from the published literature. Weighted median progression free survival and overall survival were calculated and compared to standard therapy or other experimental therapies. A qualitative analysis of the limited studies on health related quality of life and effects on steroid requirements was also undertaken. We found that the available literature supports the use of bevacizumab for prolonging PFS and OS in the recurrent setting either alone or in combination with a cytotoxic agent (P < 0.05), but does not support its use in the primary setting (P > 0.05). The survival advantage of bevacizumab compared to experimental therapy at recurrence is limited to 4 months. There is no additional benefit reported to date in health-related quality of life with the use of bevacizumab, although it may reduce steroid requirements. On average there is one side-effect event per patient and 74% of these events are grade 3 toxicity or higher. Further studies investigating the role of bevacizumab in combination with cytotoxic agents at recurrence are awaited.

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Title: The role of bevacizumab in the treatment of glioblastoma
Authors: Roberto Jose Diaz
Sheikh Ali
Mehreen Gull Qadir
Macarena I. De La Fuente
Michael E. Ivan
Ricardo J. Komotar
Publication date: 01-07-2017
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 3/2017
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-017-2477-x

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

The role of bevacizumab in the treatment of glioblastoma

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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