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01-08-2018 | Original Article

Neuroprotective efficiency of Mangifera indica leaves extract on cadmium-induced cortical damage in rats

Authors: Naif E. Al omairi, Omyma K. Radwan, Yahea A. Alzahrani, Rami B. Kassab

Published in: Metabolic Brain Disease | Issue 4/2018

Abstract

Due to the high ability of cadmium to cross the blood–brain barrier, cadmium (Cd) causes severe neurological damages. Hence, the purpose of this study was to investigate the possible protective effect of Mangifera indica leaf extract (MLE) against Cd-induced neurotoxicity. Rats were divided into eight groups. Group 1 served as vehicle control group, groups 2, 3 and 4 received MLE (100, 200, 300 mg /kg b.wt, respectively). Group 5 was treated with CdCl₂ (5 mg/kg b.wt). Groups 6, 7 and 8 were co-treated with MLE and CdCl₂ using the same doses. All treatments were orally administered for 28 days. Cortical oxidative stress biomarkers [Malondialdehyde (MDA), nitric oxide (NO), glutathione content (GSH), oxidized form of glutathione (GSSG), 8-hydroxy-2-deoxyguanosine (8-OHdG), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)], inflammatory cytokines [tumor necrosis factor (TNF-α) and interlukin-1β (IL-1β)], biogenic amines [norepinephrine (NE), dopamine (DA) and serotonin (5-HT)], some biogenic metabolites [3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA)], acetylcholine esterase activity (AChE) and purinergic compound [adenosine triphosphate (ATP)] were determined in frontal cortex of rats. Results indicated that Cd increased levels of the oxidative biomarkers (MDA, NO, GSSG and 8-OHdG) and the inflammatory mediators (TNF-α and IL-1β), while lowered GSH, SOD, CAT, GPx and ATP levels. Also, Cd significantly decreased the AChE activity and the tested biogenic amines while elevated the tested metabolites in the frontal cortex. Levels of all disrupted cortical parameters were alleviated by MLE co-administration. The MLE induced apparent protective effect on Cd-induced neurotoxicity in concern with its medium and higher doses which may be due to its antioxidant and anti-inflammatory activities.

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Title: Neuroprotective efficiency of Mangifera indica leaves extract on cadmium-induced cortical damage in rats
Authors: Naif E. Al omairi
Omyma K. Radwan
Yahea A. Alzahrani
Rami B. Kassab
Publication date: 01-08-2018
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 4/2018
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-018-0222-6

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Neuroprotective efficiency of Mangifera indica leaves extract on cadmium-induced cortical damage in rats

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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