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Open Access 01-06-2015 | Review Article

Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings

Authors: Ibrahim Jalloh, Keri L. H. Carpenter, Adel Helmy, T. Adrian Carpenter, David K. Menon, Peter J. Hutchinson

Published in: Metabolic Brain Disease | Issue 3/2015

Abstract

The pathophysiology of traumatic brain (TBI) injury involves changes to glucose uptake into the brain and its subsequent metabolism. We review the methods used to study cerebral glucose metabolism with a focus on those used in clinical TBI studies. Arterio-venous measurements provide a global measure of glucose uptake into the brain. Microdialysis allows the in vivo sampling of brain extracellular fluid and is well suited to the longitudinal assessment of metabolism after TBI in the clinical setting. A recent novel development is the use of microdialysis to deliver glucose and other energy substrates labelled with carbon-13, which allows the metabolism of glucose and other substrates to be tracked. Positron emission tomography and magnetic resonance spectroscopy allow regional differences in metabolism to be assessed. We summarise the data published from these techniques and review their potential uses in the clinical setting.

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Title: Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings
Authors: Ibrahim Jalloh
Keri L. H. Carpenter
Adel Helmy
T. Adrian Carpenter
David K. Menon
Peter J. Hutchinson
Publication date: 01-06-2015
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 3/2015
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-014-9628-y

At a glance: The STEP trials

Springer Medicine

Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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