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01-06-2015 | Research Article

Low-grade chronic inflammation induces behavioral stereotypy in rats

Authors: Oytun Erbaş, Hüseyin Serdar Akseki, Hüseyin Aktuğ, Dilek Taşkıran

Published in: Metabolic Brain Disease | Issue 3/2015

Abstract

Schizophrenia is known to be associated with metabolic disturbances including diabetes mellitus, obesity and cardiovascular diseases. A growing body of evidence has suggested abnormal cytokine levels in schizophrenia. In the present study, we explored the effects of low-grade chronic inflammation on behavioral stereotypy in a rat model of non-alcoholic fatty liver disease (NAFLD). In order to induce NAFLD, rats were fed with either water enriched with 30 % fructose or plain tap water for 8 weeks. Following feeding period, behavioral stereotypy was evaluated with apomorphine-induced stereotypy test. Also, levels of tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2) and nuclear factor kappa B (NF-κB) in the liver and brain tissues were assessed biochemically. Brain homovanilic acid (HVA) was measured to evaluate the dopamine turnover. NAFLD rats showed significantly higher stereotypy score compared to controls (p = 0.016). TNF-α, IL-2, and NF-κB levels were significantly increased in NAFLD rats compared to control group. Brain HVA levels were elevated in NAFLD rats as well (p = 0.008). Morever, NAFLD group prompted a considerable increase in brain IL-2 immunoexpression (p = 0.005). In conclusion, the present study demonstrates that low-grade chronic inflammation such as NAFLD may enhance apomorphine-induced stereotypic behavior via increasing dopaminergic activity in rats.

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Title: Low-grade chronic inflammation induces behavioral stereotypy in rats
Authors: Oytun Erbaş
Hüseyin Serdar Akseki
Hüseyin Aktuğ
Dilek Taşkıran
Publication date: 01-06-2015
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 3/2015
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-014-9630-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Low-grade chronic inflammation induces behavioral stereotypy in rats

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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