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Published in: Maternal and Child Health Journal 4/2016

01-04-2016 | Original Paper

Early Childhood Adversity and Pregnancy Outcomes

Authors: Megan V. Smith, Nathan Gotman, Kimberly A. Yonkers

Published in: Maternal and Child Health Journal | Issue 4/2016

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Abstract

Objectives To examine the association between adverse childhood experiences (ACEs) and pregnancy outcomes; to explore mediators of this association including psychiatric illness and health habits. Methods Exposure to ACEs was determined by the Early Trauma Inventory Self Report Short Form; psychiatric diagnoses were generated by the Composite International Diagnostic Interview administered in a cohort of 2303 pregnant women. Linear regression and structural equation modeling bootstrapping approaches tested for multiple mediators. Results Each additional ACE decreased birth weight by 16.33 g and decreased gestational age by 0.063. Smoking was the strongest mediator of the effect on gestational age. Conclusions ACEs have an enduring effect on maternal reproductive health, as manifested by mothers’ delivery of offspring that were of reduced birth weight and shorter gestational age.
Literature
1.
go back to reference Fagundes, C., Glaser, R., Johnson, S., Andridge, R., Yang, E., DiGregorio, M., et al. (2012). Basal cell carcinoma: Stressful life events and the tumor environment. Archives of General Psychiatry, 69(6), 618–626.CrossRefPubMedPubMedCentral Fagundes, C., Glaser, R., Johnson, S., Andridge, R., Yang, E., DiGregorio, M., et al. (2012). Basal cell carcinoma: Stressful life events and the tumor environment. Archives of General Psychiatry, 69(6), 618–626.CrossRefPubMedPubMedCentral
2.
go back to reference Felitti, V., & Anda, R. (2009). The relationship of adverse childhood experiences to adult medical disease, psychiatric disorders, and sexual behavior: Implications for healthcare. In R. Lanius & E. Vermetten (Eds.), The hidden epidemic: The impact of early life trauma on health and disease. Cambridge: Cambridge University Press. Felitti, V., & Anda, R. (2009). The relationship of adverse childhood experiences to adult medical disease, psychiatric disorders, and sexual behavior: Implications for healthcare. In R. Lanius & E. Vermetten (Eds.), The hidden epidemic: The impact of early life trauma on health and disease. Cambridge: Cambridge University Press.
3.
go back to reference Shonkoff, J. P., Garner, A. S., The Committee on Psychosocial Aspects of Child and Family Health, Committee on Early Child Adoption DC, & Section of Developmental and Behavioral Pediatrics. (2012). The lifelong effects of early childhood adversity and toxic stress. Pediatrics, 129(1), 232–246.CrossRef Shonkoff, J. P., Garner, A. S., The Committee on Psychosocial Aspects of Child and Family Health, Committee on Early Child Adoption DC, & Section of Developmental and Behavioral Pediatrics. (2012). The lifelong effects of early childhood adversity and toxic stress. Pediatrics, 129(1), 232–246.CrossRef
4.
go back to reference Danese, A., Moffitt, T. E., Harrington, H., Milne, B., Polanczyk, G., Pariante, C., et al. (2009). Adverse childhood experiences and adult risk factors for age-related disease. Archives of Pediatrics and Adolescent Medicine, 163(12), 1135–1143.CrossRefPubMedPubMedCentral Danese, A., Moffitt, T. E., Harrington, H., Milne, B., Polanczyk, G., Pariante, C., et al. (2009). Adverse childhood experiences and adult risk factors for age-related disease. Archives of Pediatrics and Adolescent Medicine, 163(12), 1135–1143.CrossRefPubMedPubMedCentral
5.
go back to reference Springer, K., Sheridan, J., Kuo, D., & Carnesb, M. (2007). Long-term physical and mental health consequences of childhood physical abuse: Results from a large population-based sample of men and women. Child Abuse and Neglect, 31, 517–530.CrossRefPubMedPubMedCentral Springer, K., Sheridan, J., Kuo, D., & Carnesb, M. (2007). Long-term physical and mental health consequences of childhood physical abuse: Results from a large population-based sample of men and women. Child Abuse and Neglect, 31, 517–530.CrossRefPubMedPubMedCentral
6.
go back to reference Mamun, A., Rosa, A., O’Callaghan, M., Hayatbakhsh, M., O’Callaghan, F., Najman, J., et al. (2011). Does childhood sexual abuse have an effect on young adults’ nicotine disorder (dependence or withdrawal)? Evidence from a birth cohort study. Addiction, 102, 647–654.CrossRef Mamun, A., Rosa, A., O’Callaghan, M., Hayatbakhsh, M., O’Callaghan, F., Najman, J., et al. (2011). Does childhood sexual abuse have an effect on young adults’ nicotine disorder (dependence or withdrawal)? Evidence from a birth cohort study. Addiction, 102, 647–654.CrossRef
7.
go back to reference Anda, R. F., Chapman, D. P., Felitti, V. J., Edwards, V., Williamson, D. F., Croft, J. B., et al. (2002). Adverse childhood experiences and risk of paternity in teen pregnancy. Obstetrics and Gynecology, 100(1), 37–45.PubMed Anda, R. F., Chapman, D. P., Felitti, V. J., Edwards, V., Williamson, D. F., Croft, J. B., et al. (2002). Adverse childhood experiences and risk of paternity in teen pregnancy. Obstetrics and Gynecology, 100(1), 37–45.PubMed
8.
go back to reference Anda, R., Croft, J., Felitti, V., Nordenberg, D., Giles, W., Williamson, D., et al. (1999). Adverse childhood experiences and smoking during adolescence and adulthood. JAMA, 282, 1652–1658.CrossRefPubMed Anda, R., Croft, J., Felitti, V., Nordenberg, D., Giles, W., Williamson, D., et al. (1999). Adverse childhood experiences and smoking during adolescence and adulthood. JAMA, 282, 1652–1658.CrossRefPubMed
9.
go back to reference Hillis, S., Anda, R., Dube, S., Felitti, V., Marchbanks, P., & Marks, J. (2004). The association between adverse childhood experiences and adolescent pregnancy, long-term psychosocial consequences, and fetal death. Pediatrics, 113(2), 320–327.CrossRefPubMed Hillis, S., Anda, R., Dube, S., Felitti, V., Marchbanks, P., & Marks, J. (2004). The association between adverse childhood experiences and adolescent pregnancy, long-term psychosocial consequences, and fetal death. Pediatrics, 113(2), 320–327.CrossRefPubMed
10.
go back to reference Teicher, M., Andersen, S., Polcari, A., Anderson, C., & Navalta, C. (2002). Developmental neurobiology of childhood stress and trauma. Psychiatric Clinics of North America, 25(2), 397–426.CrossRefPubMed Teicher, M., Andersen, S., Polcari, A., Anderson, C., & Navalta, C. (2002). Developmental neurobiology of childhood stress and trauma. Psychiatric Clinics of North America, 25(2), 397–426.CrossRefPubMed
11.
go back to reference Felitti, V., Anda, R., Nordenberg, D., Williamson, D., Spitz, A., Edwards, V., et al. (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. American Journal of Preventive Medicine, 14(4), 245–258.CrossRefPubMed Felitti, V., Anda, R., Nordenberg, D., Williamson, D., Spitz, A., Edwards, V., et al. (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. American Journal of Preventive Medicine, 14(4), 245–258.CrossRefPubMed
12.
go back to reference Dunkel Schetter, C., & Tanner, L. (2012). Anxiety, depression and stress in pregnancy: Implications for mothers, children, research, and practice. Curr Opin Psychiatry, 25(2), 141–148.CrossRefPubMedPubMedCentral Dunkel Schetter, C., & Tanner, L. (2012). Anxiety, depression and stress in pregnancy: Implications for mothers, children, research, and practice. Curr Opin Psychiatry, 25(2), 141–148.CrossRefPubMedPubMedCentral
13.
go back to reference Dunkel Schetter, C. (2011). Pregnancy: Stress processes, biopsychosocial models, and emerging research issues. Annual Review of Psychology, 62, 531–558.CrossRefPubMed Dunkel Schetter, C. (2011). Pregnancy: Stress processes, biopsychosocial models, and emerging research issues. Annual Review of Psychology, 62, 531–558.CrossRefPubMed
14.
go back to reference Benedict, M., Paine, L., Paine, L., Brandt, D., & Stallings, R. (1999). The association of childhood sexual abuse with depressive symptoms during pregnancy, and selected pregnancy outcomes. Child Abuse and Neglect, 23(7), 659–670.CrossRefPubMed Benedict, M., Paine, L., Paine, L., Brandt, D., & Stallings, R. (1999). The association of childhood sexual abuse with depressive symptoms during pregnancy, and selected pregnancy outcomes. Child Abuse and Neglect, 23(7), 659–670.CrossRefPubMed
15.
go back to reference Leeners, B., Stiller, R., Block, E., Görres, G., & Rath, W. (2010). Pregnancy complications in women with childhood sexual abuse experiences. Journal of Psychosomatic Research, 69(5), 503–510.CrossRefPubMed Leeners, B., Stiller, R., Block, E., Görres, G., & Rath, W. (2010). Pregnancy complications in women with childhood sexual abuse experiences. Journal of Psychosomatic Research, 69(5), 503–510.CrossRefPubMed
16.
go back to reference Grimstad, H., & Schei, B. (1999). Pregnancy and delivery for women with a history of child sexual abuse. Child Abuse and Neglect, 23(1), 81–90.CrossRefPubMed Grimstad, H., & Schei, B. (1999). Pregnancy and delivery for women with a history of child sexual abuse. Child Abuse and Neglect, 23(1), 81–90.CrossRefPubMed
17.
go back to reference Jacobs, J. (1992). Victimization and later sequelae during pregnancy and childbirth. Journal of Child Sexual Abuse, 1(1), 103–112.CrossRef Jacobs, J. (1992). Victimization and later sequelae during pregnancy and childbirth. Journal of Child Sexual Abuse, 1(1), 103–112.CrossRef
18.
go back to reference Seng, J., Low, L., Sperlich, M., Ronis, D., & Liberzonf, I. (2011). Post-traumatic stress disorder, child abuse history, birthweight and gestational age: A prospective cohort study. BJOG, 118(13), 1329–1339.CrossRefPubMedPubMedCentral Seng, J., Low, L., Sperlich, M., Ronis, D., & Liberzonf, I. (2011). Post-traumatic stress disorder, child abuse history, birthweight and gestational age: A prospective cohort study. BJOG, 118(13), 1329–1339.CrossRefPubMedPubMedCentral
19.
go back to reference Noll, J. G., Schulkin, J., Trickett, P. K., Susman, E. J., Breech, L., & Putnam, F. W. (2007). Differential pathways to preterm delivery for sexually abused and comparison women. Journal of Pediatric Psychology, 32(10), 1238.CrossRefPubMed Noll, J. G., Schulkin, J., Trickett, P. K., Susman, E. J., Breech, L., & Putnam, F. W. (2007). Differential pathways to preterm delivery for sexually abused and comparison women. Journal of Pediatric Psychology, 32(10), 1238.CrossRefPubMed
20.
go back to reference Chung, E. K., Nurmohamed, L., Mathew, L., Elo, I. T., Coyne, J. C., & Culhane, J. F. (2010). Risky health behaviors among mothers-to-be: The impact of adverse childhood experiences. Academic Pediatrics, 10(4), 245–251.CrossRefPubMedPubMedCentral Chung, E. K., Nurmohamed, L., Mathew, L., Elo, I. T., Coyne, J. C., & Culhane, J. F. (2010). Risky health behaviors among mothers-to-be: The impact of adverse childhood experiences. Academic Pediatrics, 10(4), 245–251.CrossRefPubMedPubMedCentral
21.
go back to reference Möhler, E., Matheis, V., Marysko, M., Finke, P., Kaufmann, C., Cierpka, M., et al. (2008). Complications during pregnancy, peri- and postnatal period in a sample of women with a history of child abuse. Journal of Psychosomatic Obstetrics and Gynecology, 29(3), 193–198.CrossRefPubMed Möhler, E., Matheis, V., Marysko, M., Finke, P., Kaufmann, C., Cierpka, M., et al. (2008). Complications during pregnancy, peri- and postnatal period in a sample of women with a history of child abuse. Journal of Psychosomatic Obstetrics and Gynecology, 29(3), 193–198.CrossRefPubMed
22.
go back to reference Chung, E., Mathew, L., Elo, I., et al. (2008). Depressive symptoms in disadvantaged women receiving prenatal care: The influence of adverse and positive childhood experiences. Ambulatory Pediatrics, 8(2), 109–116.CrossRefPubMed Chung, E., Mathew, L., Elo, I., et al. (2008). Depressive symptoms in disadvantaged women receiving prenatal care: The influence of adverse and positive childhood experiences. Ambulatory Pediatrics, 8(2), 109–116.CrossRefPubMed
23.
go back to reference Farber, E., Herbert, S., & Reviere, S. (1996). Childhood abuse and suicidality in obstetric patients in a hospital-based urban prenatal clinic. General Hospital Psychiatry, 18, 56–60.CrossRefPubMed Farber, E., Herbert, S., & Reviere, S. (1996). Childhood abuse and suicidality in obstetric patients in a hospital-based urban prenatal clinic. General Hospital Psychiatry, 18, 56–60.CrossRefPubMed
24.
go back to reference Lukasse, M., Schei, B., Vangen, S., & Oian, P. (2009). Childhood abuse and common complaints in pregnancy. Birth, 36(3), 190–199.CrossRefPubMed Lukasse, M., Schei, B., Vangen, S., & Oian, P. (2009). Childhood abuse and common complaints in pregnancy. Birth, 36(3), 190–199.CrossRefPubMed
25.
go back to reference Greenfield, E. (2010). Childhood sexual abuse as a life-course social determinnant of adult health. Maturitas, 66(66), 51–55.CrossRefPubMed Greenfield, E. (2010). Childhood sexual abuse as a life-course social determinnant of adult health. Maturitas, 66(66), 51–55.CrossRefPubMed
26.
go back to reference Seng, J., Sperlich, M., & Low, L. (2008). Mental health, demographic, and risk behavior profiles of pregnant survivors of childhood and adult abuse. Journal of Midwifery and Women’s Health, 53(6), 511–521.CrossRefPubMedPubMedCentral Seng, J., Sperlich, M., & Low, L. (2008). Mental health, demographic, and risk behavior profiles of pregnant survivors of childhood and adult abuse. Journal of Midwifery and Women’s Health, 53(6), 511–521.CrossRefPubMedPubMedCentral
27.
go back to reference Yonkers, K. A., Norwitz, E. R., Smith, M. V., Lockwood, C. J., Gotman, N., Luchansky, E., et al. (2012). Depression and serotonin reuptake inhibitor treatment as risk factors for preterm birth. Epidemiology, 23(5), 677–685.CrossRefPubMedPubMedCentral Yonkers, K. A., Norwitz, E. R., Smith, M. V., Lockwood, C. J., Gotman, N., Luchansky, E., et al. (2012). Depression and serotonin reuptake inhibitor treatment as risk factors for preterm birth. Epidemiology, 23(5), 677–685.CrossRefPubMedPubMedCentral
28.
go back to reference Kessler, R., & Ustun, T. B. (2004). The world mental health (WMH) survey initiative version of the world health organization (WHO) composite international diagnostic interview (CIDI). The International Journal of Methods in Psychiatric Research, 13(2), 93–121.CrossRefPubMed Kessler, R., & Ustun, T. B. (2004). The world mental health (WMH) survey initiative version of the world health organization (WHO) composite international diagnostic interview (CIDI). The International Journal of Methods in Psychiatric Research, 13(2), 93–121.CrossRefPubMed
29.
go back to reference Falsetti, S., Resnick, H., Pesick, P., & Kilpatrick, D. (1993). The modified PTSD symptom scale: A brief self-report measure of posttraumatic stress disorder. Behavior Therapist, 16, 161–162. Falsetti, S., Resnick, H., Pesick, P., & Kilpatrick, D. (1993). The modified PTSD symptom scale: A brief self-report measure of posttraumatic stress disorder. Behavior Therapist, 16, 161–162.
30.
go back to reference Bremner, J. D. (2007). Neuroimaging in posttraumatic stress disorder and other stress-related disorders. Neuroimaging Clinics of North America, 17(4), 523.CrossRefPubMedPubMedCentral Bremner, J. D. (2007). Neuroimaging in posttraumatic stress disorder and other stress-related disorders. Neuroimaging Clinics of North America, 17(4), 523.CrossRefPubMedPubMedCentral
31.
go back to reference Preacher, K., & Hayes, A. (2004). SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behavior Research Methods, Instruments, and Computers, 36, 717–731.CrossRefPubMed Preacher, K., & Hayes, A. (2004). SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behavior Research Methods, Instruments, and Computers, 36, 717–731.CrossRefPubMed
32.
go back to reference MacKinnon, D., Lockwood, C., Hoffman, J., West, S., & Sheets, V. (2002). A comparison of methods to test mediation and other intervening variable effects. Psychological Methods, 7, 83–104.CrossRefPubMedPubMedCentral MacKinnon, D., Lockwood, C., Hoffman, J., West, S., & Sheets, V. (2002). A comparison of methods to test mediation and other intervening variable effects. Psychological Methods, 7, 83–104.CrossRefPubMedPubMedCentral
33.
go back to reference Hill, T. D., Kaplan, L. M., French, M. T., & Johnson, R. J. (2010). Victimatization in early life and mental health in adulthood: An examination of the mediating and moderating influences of psychosocial resources. Journal of Health and Social Behavior, 51(1), 48–63.CrossRefPubMed Hill, T. D., Kaplan, L. M., French, M. T., & Johnson, R. J. (2010). Victimatization in early life and mental health in adulthood: An examination of the mediating and moderating influences of psychosocial resources. Journal of Health and Social Behavior, 51(1), 48–63.CrossRefPubMed
Metadata
Title
Early Childhood Adversity and Pregnancy Outcomes
Authors
Megan V. Smith
Nathan Gotman
Kimberly A. Yonkers
Publication date
01-04-2016
Publisher
Springer US
Published in
Maternal and Child Health Journal / Issue 4/2016
Print ISSN: 1092-7875
Electronic ISSN: 1573-6628
DOI
https://doi.org/10.1007/s10995-015-1909-5

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