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Journal of Mammary Gland Biology and Neoplasia
Published in: Journal of Mammary Gland Biology and Neoplasia 1/2017

01-03-2017

Mouse Models of Breast Cancer Share Amplification and Deletion Events with Human Breast Cancer

Authors: Jonathan Rennhack, Briana To, Harrison Wermuth, Eran R. Andrechek

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 1/2017

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Abstract

Breast tumor heterogeneity has been well documented through the use of multiplatform –omic studies in human tumors. However, there is no integrative database to capture the heterogeneity within mouse models of breast cancer. This project identifies genomic copy number alterations (CNAs) in 600 tumors across 27 major mouse models of breast cancer through the application of a predictive algorithm to publicly available gene expression data. It was found that despite the presence of strong oncogenic drivers in most mouse models, CNAs are extremely common but heterogeneous both between models and within models. Many mouse CNA events are largely conserved in human tumors and in the mouse we show that they are associated with secondary tumor characteristics such as tumor histology, metastasis, as well as enhanced oncogenic signaling. These data serve as an important resource in guiding investigators when choosing a mouse model to understand the gene copy number changes relevant to human breast cancer.
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Metadata
Title
Mouse Models of Breast Cancer Share Amplification and Deletion Events with Human Breast Cancer
Authors
Jonathan Rennhack
Briana To
Harrison Wermuth
Eran R. Andrechek
Publication date
01-03-2017
Publisher
Springer US
Published in
Journal of Mammary Gland Biology and Neoplasia / Issue 1/2017
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI
https://doi.org/10.1007/s10911-017-9374-y

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