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Journal of Mammary Gland Biology and Neoplasia
Published in: Journal of Mammary Gland Biology and Neoplasia 3/2008

01-09-2008

Signal Transduction in Transgenic Mouse Models of Human Breast Cancer—Implications for Human Breast Cancer

Authors: Richard Marcotte, William J. Muller

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 3/2008

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Abstract

The advent of genetically engineered mouse models (GEMs) of human breast cancer, have provided important insight into molecular basis or human breast cancer. This review will focus on two of the most extensively studied mouse models for human breast cancer involving mammary gland specific expression of the polyoma middle T (PyV MT) antigen and of the ErbB2. In addition, this review will discuss past and recent advances in understanding relative contribution of the signaling pathways in tumor induction and metastasis by these potent mammary oncogenes.
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Metadata
Title
Signal Transduction in Transgenic Mouse Models of Human Breast Cancer—Implications for Human Breast Cancer
Authors
Richard Marcotte
William J. Muller
Publication date
01-09-2008
Publisher
Springer US
Published in
Journal of Mammary Gland Biology and Neoplasia / Issue 3/2008
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI
https://doi.org/10.1007/s10911-008-9087-3

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