Effect of patent ductus arteriosus and patent foramen ovale on left ventricular stroke volume measurement by electrical velocimetry in comparison to transthoracic echocardiography in neonates

This prospective single-center observational study compared impedance cardiography [electrical velocimetry (EV)] with transthoracic echocardiography (TTE, based on trans-aortic flow) and analyzed the influence of physiological shunts, such as patent ductus arteriosus (PDA) or patent foramen ovale (PFO), on measurement accuracy. Two hundred and ninety-one triplicate simultaneous paired left ventricular stroke volume (LVSV) measurements by EV (LVSV_EV) and TTE (LVSV_TTE) in 99 spontaneously breathing neonates (mean weight 3270 g; range 1227–4600 g) were included. For the whole cohort, the mean absolute LVSV_EV was 5.5 mL, mean LVSV_TTE was 4.9 mL, resulting in an absolute Bland–Altman bias of −0.7 mL (limits of agreement LOA −3.0 to 1.7 mL), relative bias −12.8 %; mean percentage error MPE 44.9 %; true precision TP_EV 33.4 % (n = 99 aggregated data points). In neonates without shunts (n = 32): mean LVSV_EV 5.0 mL, mean LVSV_TTE 4.6 mL, Bland–Altman bias −0.4 mL (LOA −2.8 to 2.0 mL), relative bias −8.2 %; MPE 50.7 %; TP_EV 40.9 %. In neonates with shunts (PDA and/or PFO; n = 67): mean LVSV_EV 5.8 mL, mean LVSV_TTE 5.0 mL, bias −0.8 mL (LOA −3.1 to 1.5 mL), relative bias −14.8 %, MPE 41.9 %, TP_EV 29.3 %. Accuracy was affected by PDA and/or PFO, with a significant increase in the relative difference in LVSV_EV versus LVSV_TTE: Subjects without shunts −2.9 % (n = 91), PFO alone −9.6 % (n = 125), PDA alone −14.0 % (n = 12), and PDA and PFO −18.5 % (n = 63). Physiological shunts (PDA and/or PFO) in neonates affect measurement accuracy and cause overestimation of LVSV_EV compared with LVSV_TTE.