Published in:
01-05-2017 | Letter to Editor
Paecilomyces formosus Infection in an Adult Patient with Undiagnosed Chronic Granulomatous Disease
Authors:
Jalal Heshmatnia, Majid Marjani, Seyed Alireza Mahdaviani, Parvaneh Adimi, Mihan Pourabdollah, Payam Tabarsi, Fereshte Mahdavi, Hamidreza Jamaati, Ian M. Adcock, Johan Garssen, Aliakbar Velayati, Davood Mansouri, Esmaeil Mortaz
Published in:
Journal of Clinical Immunology
|
Issue 4/2017
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Excerpt
Chronic granulomatous disease (CGD), an inherited disorder of granulocyte function caused by a failure of intracellular superoxide production, normally presents as severe recurrent bacterial and fungal infections in the first years of life [
1,
2]. These recurrent infections occur at epithelial surfaces in direct contact with the environment such as the skin and the mucosal surfaces of the lungs and gut. The majority of affected individuals are diagnosed before the age of 2 years, although patients may remain undiagnosed until adulthood despite the early onset of the symptoms. Lymphadenitis is the most common presenting feature, followed by skin abscesses, pneumonia, and hepatomegaly [
3]. …
