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Journal of Clinical Immunology

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01-05-2017 | Letter to Editor

Persistent Impairment of T-Cell Regeneration in a Patient with Activated PI3K δ Syndrome

Authors: Fumihiro Goto, Toru Uchiyama, Yumiko Nakazawa, Kohsuke Imai, Toshinao Kawai, Masafumi Onodera

Published in: Journal of Clinical Immunology | Issue 4/2017

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Angulo I, Vadas O, Garcon F, Banham-Hall E, Plagnol V, et al. Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory infection and airway damage. Science. 2013;342(6160):866–71.CrossRefPubMedPubMedCentral

Lucas CL, Kuehn HS, Zhao F, Niemela JE, Deenick EK, et al. Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110delta result in T cell senescence and human immunodeficiency. Nat Immunol. 2014;15(1):88–97.CrossRefPubMed

Rae W, Ramakrishnan KA, Gao Y, Ashton-Key M, Pengelly RJ, et al. Precision treatment with sirolimus in a case of activated phosphoinositide 3-kinase delta syndrome. Clin Immunol. 2016;171:38–40.CrossRefPubMed

Chapman NM, Chi HB. mTOR links environmental signals to T cell fate decisions. Front Immunol. 2015;5:1–11.CrossRef

Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, et al. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol. 2009;10(2):176–84.CrossRefPubMedPubMedCentral

Title: Persistent Impairment of T-Cell Regeneration in a Patient with Activated PI3K δ Syndrome
Authors: Fumihiro Goto
Toru Uchiyama
Yumiko Nakazawa
Kohsuke Imai
Toshinao Kawai
Masafumi Onodera
Publication date: 01-05-2017
Publisher: Springer US
Published in: Journal of Clinical Immunology / Issue 4/2017
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-017-0393-7

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