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Journal of Clinical Immunology

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Open Access 01-02-2017 | Letter to Editor

Increased Mucosal IL-22 Production of an IL-10RA Mutation Patient Following Anakinra Treatment Suggests Further Mechanism for Mucosal Healing

Authors: Jian Li, Dror S. Shouval, Andria L. Doty, Scott B. Snapper, Sarah C. Glover

Published in: Journal of Clinical Immunology | Issue 2/2017

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Shouval DS, Ouahed J, Biswas A, Goettel JA, Horwitz BH, Klein C, et al. Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv Immunol. 2014;122:177–210.CrossRefPubMedPubMedCentral

Glocker EO, Kotlarz D, Boztug K, Gertz EM, Schaffer AA, Noyan F, et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med. 2009;361(21):2033–45.CrossRefPubMedPubMedCentral

Shouval DS, Biswas A, Kang YH, Griffith AE, Konnikova L, Mascanfroni ID et al. Interleukin 1 beta mediates intestinal inflammation in mice and patients with IL10 receptor deficiency. Gastroenterology. 2016.

Tzanetakou V, Kanni T, Giatrakou S, Katoulis A, Papadavid E, Netea MG, et al. Safety and efficacy of anakinra in severe hidradenitis suppurativa: a randomized clinical trial. JAMA Dermatol. 2016;152(1):52–9.CrossRefPubMed

Leung JM, Davenport M, Wolff MJ, Wiens KE, Abidi WM, Poles MA, et al. IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue. Mucosal Immunol. 2014;7(1):124–33.CrossRefPubMed

Title: Increased Mucosal IL-22 Production of an IL-10RA Mutation Patient Following Anakinra Treatment Suggests Further Mechanism for Mucosal Healing
Authors: Jian Li
Dror S. Shouval
Andria L. Doty
Scott B. Snapper
Sarah C. Glover
Publication date: 01-02-2017
Publisher: Springer US
Published in: Journal of Clinical Immunology / Issue 2/2017
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-016-0365-3

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