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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 5/2015

01-07-2015 | CME Review

Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy

Authors: Kai Kisand, Pärt Peterson

Published in: Journal of Clinical Immunology | Issue 5/2015

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Abstract

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autosomal recessive disease caused by mutations in the autoimmune regulator (AIRE) gene. This review focuses on the clinical and immunological features of APECED, summarizes the current knowledge on the function of AIRE and discusses the importance of autoantibodies in disease diagnosis and prognosis. Additionally, we review the outcome of recent immunomodulatory treatments in APECED patients.
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Metadata
Title
Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy
Authors
Kai Kisand
Pärt Peterson
Publication date
01-07-2015
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 5/2015
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-015-0176-y

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