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Published in:

01-07-2014

Fc Glycan-Modulated Immunoglobulin G Effector Functions

Authors: Isaak Quast, Jan D. Lünemann

Published in: Journal of Clinical Immunology | Special Issue 1/2014

Abstract

Immunoglobulin G (IgG) molecules are glycoproteins and residues in the sugar moiety attached to the IgG constant fragment (Fc) are essential for IgG functionality such as binding to cellular Fc receptors and complement activation. The core of this sugar moiety consists of a bi-antennary heptameric structure of mannose and N-acetylglucosamine (GlcNAc), further decorated with terminal and branching residues including galactose, sialic acid, fucose, and GlcNAc. Presence or absence of distinct residues such as fucose and sialic acid can dramatically alter pro- and anti-inflammatory IgG activities which could be harnessed for immunotherapeutic purposes. Here we review recent advances in understanding the role of the IgG-Fc glycan during immune responses and for immunotherapy with a focus on sialic acid and intravenous immunoglobulin (IVIG) treatment.

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Title: Fc Glycan-Modulated Immunoglobulin G Effector Functions
Authors: Isaak Quast
Jan D. Lünemann
Publication date: 01-07-2014
Publisher: Springer US
Published in: Journal of Clinical Immunology / Issue Special Issue 1/2014
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-014-0018-3

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