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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 1/2014

Open Access 01-01-2014 | Key Review Article

Attending to Warning Signs of Primary Immunodeficiency Diseases Across the Range of Clinical Practice

Authors: Beatriz Tavares Costa-Carvalho, Anete Sevciovic Grumach, José Luis Franco, Francisco Javier Espinosa-Rosales, Lily E. Leiva, Alejandra King, Oscar Porras, Liliana Bezrodnik, Mathias Oleastro, Ricardo U. Sorensen, Antonio Condino-Neto

Published in: Journal of Clinical Immunology | Issue 1/2014

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Abstract

Purpose

Patients with primary immunodeficiency diseases (PIDD) may present with recurrent infections affecting different organs, organ-specific inflammation/autoimmunity, and also increased cancer risk, particularly hematopoietic malignancies. The diversity of PIDD and the wide age range over which these clinical occurrences become apparent often make the identification of patients difficult for physicians other than immunologists. The aim of this report is to develop a tool for educative programs targeted to specialists and applied by clinical immunologists.

Methods

Considering the data from national surveys and clinical reports of experiences with specific PIDD patients, an evidence-based list of symptoms, signs, and corresponding laboratory tests were elaborated to help physicians other than immunologists look for PIDD.

Results

Tables including main clinical manifestations, restricted immunological evaluation, and possible related diagnosis were organized for general practitioners and 5 specialties. Tables include information on specific warning signs of PIDD for pulmonologists, gastroenterologists, dermatologists, hematologists, and infectious disease specialists.

Conclusions

This report provides clinical immunologists with an instrument they can use to introduce specialists in other areas of medicine to the warning signs of PIDD and increase early diagnosis. Educational programs should be developed attending the needs of each specialty.
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Metadata
Title
Attending to Warning Signs of Primary Immunodeficiency Diseases Across the Range of Clinical Practice
Authors
Beatriz Tavares Costa-Carvalho
Anete Sevciovic Grumach
José Luis Franco
Francisco Javier Espinosa-Rosales
Lily E. Leiva
Alejandra King
Oscar Porras
Liliana Bezrodnik
Mathias Oleastro
Ricardo U. Sorensen
Antonio Condino-Neto
Publication date
01-01-2014
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 1/2014
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-013-9954-6

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