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01-05-2013 | Original Research

Diabetes, Renal and Cardiovascular Disease in p47^phox−/− Chronic Granulomatous Disease

Authors: Jennifer W. Leiding, Beatriz E. Marciano, Christa S. Zerbe, Suk See DeRavin, Harry L. Malech, Steven M. Holland

Published in: Journal of Clinical Immunology | Issue 4/2013

Abstract

Chronic granulomatous disease is a rare immunodeficiency due to defects in the phagocyte NADPH oxidase. The X-linked form (gp91^phox deficiency) accounts for about 70 % of cases; autosomal recessive p47^phox deficiency accounts for about 25 % of cases. We identified a 10 % incidence of diabetes in p47^phox deficient CGD, but none in X-linked CGD. Renal and cardiovascular diseases were also higher in p47^phox deficiency. p47^phox deficient CGD has non-infectious morbidities distinct from those in X-linked CGD.

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Title: Diabetes, Renal and Cardiovascular Disease in p47 phox−/− Chronic Granulomatous Disease
Authors: Jennifer W. Leiding
Beatriz E. Marciano
Christa S. Zerbe
Suk See DeRavin
Harry L. Malech
Steven M. Holland
Publication date: 01-05-2013
Publisher: Springer US
Published in: Journal of Clinical Immunology / Issue 4/2013
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-013-9871-8

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