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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 3/2011

01-06-2011

Aging Affects Human B Cell Responses

Authors: Daniela Frasca, Bonnie B. Blomberg

Published in: Journal of Clinical Immunology | Issue 3/2011

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Abstract

Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.

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Metadata
Title
Aging Affects Human B Cell Responses
Authors
Daniela Frasca
Bonnie B. Blomberg
Publication date
01-06-2011
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 3/2011
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-010-9501-7

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