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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 1/2011

01-02-2011

Expanding the Universe of Cytokines and Pattern Recognition Receptors: Galectins and Glycans in Innate Immunity

Authors: Juan P. Cerliani, Sean R. Stowell, Iván D. Mascanfroni, Connie M. Arthur, Richard D. Cummings, Gabriel A. Rabinovich

Published in: Journal of Clinical Immunology | Issue 1/2011

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Abstract

Effective immunity relies on the recognition of pathogens and tumors by innate immune cells through diverse pattern recognition receptors (PRRs) that lead to initiation of signaling processes and secretion of pro- and anti-inflammatory cytokines. Galectins, a family of endogenous lectins widely expressed in infected and neoplastic tissues have emerged as part of the portfolio of soluble mediators and pattern recognition receptors responsible for eliciting and controlling innate immunity. These highly conserved glycan-binding proteins can control immune cell processes through binding to specific glycan structures on pathogens and tumors or by acting intracellularly via modulation of selective signaling pathways. Recent findings demonstrate that various galectin family members influence the fate and physiology of different innate immune cells including polymorphonuclear neutrophils, mast cells, macrophages, and dendritic cells. Moreover, several pathogens may actually utilize galectins as a mechanism of host invasion. In this review, we aim to highlight and integrate recent discoveries that have led to our current understanding of the role of galectins in host–pathogen interactions and innate immunity. Challenges for the future will embrace the rational manipulation of galectin–glycan interactions to instruct and shape innate immunity during microbial infections, inflammation, and cancer.
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Metadata
Title
Expanding the Universe of Cytokines and Pattern Recognition Receptors: Galectins and Glycans in Innate Immunity
Authors
Juan P. Cerliani
Sean R. Stowell
Iván D. Mascanfroni
Connie M. Arthur
Richard D. Cummings
Gabriel A. Rabinovich
Publication date
01-02-2011
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 1/2011
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-010-9494-2

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10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

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