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Open Access 01-05-2010

Small RNA Regulators of T Cell-Mediated Autoimmunity

Published in: Journal of Clinical Immunology | Issue 3/2010

Abstract

Background

MicroRNAs (miRNAs) are short single-stranded RNA molecules that regulate gene expression post-transcriptionally. Several hundred miRNAs exist in the mammalian genome and regulate developmental processes, cell cycle, and survival.

Methods

In this review, we highlight general modes of miRNA function and relate them to how such regulation can be beneficial for immune homeostasis and the prevention of autoimmune diseases. We highlight examples of experimentally verified miRNA function and their target genes in the immune system and place them in context of concepts relevant to an understanding of autoimmune pathogenesis. Where available, we refer to clinical correlations. Finally, we speculate how emerging knowledge about miRNA function in the immune system might be used diagnostically and therapeutically.

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Title: Small RNA Regulators of T Cell-Mediated Autoimmunity
Publication date: 01-05-2010
Published in: Journal of Clinical Immunology / Issue 3/2010
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-010-9392-7

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Small RNA Regulators of T Cell-Mediated Autoimmunity

Abstract

Background

Methods

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Abstract

Background

Methods

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