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Journal of Clinical Immunology

Published in:

01-03-2010

The IL-17 Family Cytokines in Immunity and Disease

Authors: Rajita Pappu, Vladimir Ramirez-Carrozzi, Naruhisa Ota, Wenjun Ouyang, Yan Hu

Published in: Journal of Clinical Immunology | Issue 2/2010

Abstract

Introduction

Accumulating evidence suggests that the interleukin (IL)-17 cytokines are major players in the immune response to foreign pathogens. In addition, the pathogeneses of a number of inflammatory diseases have been linked to uncontrolled expression of these cytokine pathways.

Discussion

Genetic and biochemical analyses have elucidated the cellular and molecular events triggered by these proteins during an inflammatory response. While significant efforts have been placed on understanding the functions of IL-17A, IL-17F, and IL-17E, the significance of the other family members, IL-17B−D, in inflammation remains to be determined.

Conclusion

This review will focus on the cellular sources, target cell/receptors that are utilized by these cytokines to control pathogenesis, and the therapeutic potential of targeting these pathways to treat inflammatory disorders.

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Title: The IL-17 Family Cytokines in Immunity and Disease
Authors: Rajita Pappu
Vladimir Ramirez-Carrozzi
Naruhisa Ota
Wenjun Ouyang
Yan Hu
Publication date: 01-03-2010
Publisher: Springer US
Published in: Journal of Clinical Immunology / Issue 2/2010
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-010-9369-6

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The IL-17 Family Cytokines in Immunity and Disease

Abstract

Introduction

Discussion

Conclusion

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Abstract

Introduction

Discussion

Conclusion

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