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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 6/2008

01-11-2008

Mast Cells and the Adaptive Immune Response

Authors: Melissa A. Brown, Blayne A. Sayed, Alison Christy

Published in: Journal of Clinical Immunology | Issue 6/2008

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Abstract

Background

The idea that the innate and adaptive immune systems are not separate entities is no longer new. In fact, it is surprising that this paradigm was accepted without question for so long. Many innate cells express cell surface molecules and soluble mediators that are essential for the development and activation of T cells and B cells. Yet among the innate cell populations, mast cells may play the major role in regulating adaptive immune cell function.

Discussion

This role first came to light in studies of mast cells and their involvement in the autoimmune disease experimental allergic encephalomyelitis, the major rodent model of multiple sclerosis and has subsequently been verified in many in vitro and in vivo model systems.
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Metadata
Title
Mast Cells and the Adaptive Immune Response
Authors
Melissa A. Brown
Blayne A. Sayed
Alison Christy
Publication date
01-11-2008
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 6/2008
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-008-9247-7

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EditorialNotes

Immune Homeostasis: Regulatory T Cells (Treg) and Molecules
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