Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 5/2008

01-09-2008

Expression of Cytokine mRNA in Lymphocytes of Malnourished Children

Authors: Haydeé González-Martínez, Leonor Rodríguez, Oralia Nájera, David Cruz, Angel Miliar, Aarón Domínguez, Fausto Sánchez, Jaime Graniel, María Cristina González-Torres

Published in: Journal of Clinical Immunology | Issue 5/2008

Login to get access

Abstract

Introduction

Protein–calorie malnutrition represents a significant worldwide health problem and is associated with an increased risk for infections. The purpose of this study was to evaluate possible changes in type 1/type 2 responses balance in malnourished children.

Results

The data obtained in the present study showed that the expression levels of tumor necrosis factor-α, interleukin (IL)-4, and IL-10 were more highly, in contrast IL-2, gamma interferon, and IL-6 genes were expressed less in all groups of malnourished children compared with the well-nourished infected children. It is important to indicate that the data collected in the present work agree with the results obtained by different authors, who showed differences in the production of cytokines in malnourished children.

Conclusion

In conclusion, the results suggest that alterations in the balance of type 1/type 2 immune responses exist in malnourished children, and this could be the reason that the immunological system of the malnourished children is incapable of eradicating infections.
Literature
1.
Fernández O, Rivera J, Shamah T, Villalpando-Hernández S. Encuesta Nacional de Salud y Nutrición 2006. Cuernavaca, México: Instituto Nacional de Salud Pública, 2006.
2.
Tupasi T, Velmonte M, Sanvictores M, Abraham L, De Leon L, Tan S, et al. Determinants of morbidity and mortality due to acute respiratory infections: implications for intervention. J Infect Dis. 1988;4:615–23.
3.
Pollán J. Nutrition and immunity. Rev Esp Pediatr. 2001;57:58–74.
4.
Nájera O, González C, Cortés E, Toledo G, Ortiz R. Effector lymphocyte in well-nourished and malnourished infected children. Clin Exp Biol. 2007;148:501–6.
5.
6.
Jankovic D, Zhugong L, Gause WC. Th1- and Th2 -cell commitment during infectious disease: asymmetry in divergent pathways. Trends Immunol. 2001;22:450–7.PubMedCrossRef
7.
Arai K, Lee F, Miyajima A, Miyatake S, Arai N, Yokota T. Cytokines: coordinators of immune and inflammatory responses. Annu Rev Biochem. 1990;59:783–836.PubMedCrossRef
8.
Liles W, Van Voorhis C. Review: nomenclature and biologic significance of cytokines involved in inflammation and the host immune response. J Infect Dis. 1995;172:1573–80.PubMed
9.
Kühne B, Oschmann P. Quantitative real-time RT-PCR using hybridization probes and imported standard curves for cytokine gene expression analysis. Biotechniques. 2002;33:1078–89.PubMed
10.
Cho M, Kim Y, Lee M, Kim S. The effect of cysteine on the altered expression of class a and m glutathione S-transferase genes in the rat liver during protein–calorie malnutrition. Biochim Biophys. Acta 2000;1502:235–46.PubMed
11.
Cho M, Kim Y, Lee M, Kim S. Prevention of c-Jun/activator protein-1 activation and microsomal epoxide hydrolase induction in the rat liver by cysteine during protein–calorie malnutrition. Biochem Pharmacol. 2002;61:15–24.CrossRef
12.
Lee A, Kang K, Kim Y, Cho M, Lee M, Shim C, et al. Identification of genes enhanced by protein–calorie malnutrition by essential display protein–calorie malnutrition polymerase chain reaction (expression of fibrinogen beta chain). Cell Biochem. 2002;231:163–71.CrossRef
13.
González C, González H, Rodríguez L, Cortés E, Nájera O, Hernández-Hernández F, et al. Differential gene expression in lymphocytes from malnourished children. Cell Biol Int. 2006;30:610–4.PubMedCrossRef
14.
Ramos-Galván R. Somatometría pediátrica. Arch Inv Méd. 1976;6:5.
15.
Chandra R. 1990 McCollum Award Lecture. Nutrition and immunity: lessons from the past and new insights into the future. Am J Clin Nutr. 1991;53:1087–101.PubMed
16.
17.
Karulin A, Hesse M, Tary-Lehmann M, Lehmann P. Single-cytokine-producing CD4 memory cells predominate in type 1 and type 2 immunity. J Immunol. 2000;1164:1862–72.
18.
Lofty O, Selenh W, Barbari M. Study of some changes of cell-mediated immunity in protein energy malnutrition. J Egypt Soc Parasitol. 1998;28:413–28.
19.
Amesty V, Pereira N, García M, Núñez J, Cayama N, Villadiego N. Niveles séricos de citocinas proinflamatorias en niños con diferentes grados de desnutrición. Bol Med Hosp Infant Mex. 2003;60:14–21.
20.
Dülger H, Arik M, Ramazan M, Tarakcioglu H, Noyan M, Balahoroglu R. Pro-inflammatory cytokines in Turkish children with protein–energy malnutrition. Mediators Inflamm. 2002;11:363–5.PubMedCrossRef
21.
McMurray D, Mintzer C, Bartow R, Parr R. Dietary protein deficiency and Mycobacterium bovis BCG affect interleukin-2 activity in experimental pulmonary tuberculosis. Infect Immunol. 1989;57:2606–11.
22.
Rodríguez L, González C, Flores L, Graniel J, Ortiz R. Assessment by flow cytometry of cytokine production in malnourished children. Clin Diagn Lab Immunol. 2005;12:502–7.PubMedCrossRef
23.
Ameho C, Adjei A, Yamauchi K, Harrison E, Kulkarni A, Sato S, et al. Modulation of age-related changes in immune functions of protein-deficient senescence-accelerated mice by dietary nucleoside–nucleotide mixture supplementation. Br J Nutr. 1997;77:795–804.PubMedCrossRef
24.
Malek T. T helper cell, IL-2 and the generation of cytotoxic T cell responses. Trends Immunol. 2002;23:465–7.PubMedCrossRef
25.
Mengheri E, Nobili F, Crocchioni G, Lewis JA. Protein starvation impairs the ability of activated lymphocytes to produce interferon-gamma. J Interferon Res. 1992;12:17–21.PubMed
26.
Bogdan C. The function of type I interferons in antimicrobial immunity. Curr Opin Immunol. 2000;12:419–24.PubMedCrossRef
27.
28.
Martinez O, Gibbons R, Garavoy M, Aronson F. IL-4 inhibits IL-2 receptor expression and IL-2-dependent proliferation of human T cells. J Immunol. 1990;44:2211–5.
29.
Malavé I, Vethercourt M, Chacón R, Quiñones D, Rebrij C, Bolivar G. Production of interleukin-6 in cultures of peripheral blood mononuclear cells from children with primary protein–calorie malnutrition and from eutrophic control. Ann Nutr Metab. 1998;42:266–73.PubMedCrossRef
30.
Vethencourt M, Pirela M, Sousa P, Acuña M, Cordero R, Baute L. Correlacion entre prealbúmina, proteína C reactiva e interleuquina-6 en niños desnutridos con o sin infección clínica. Arch Lat Nutr. 1994;44:93–5.
31.
Doherty J, Golden M, Remick D, Griffin G. Production on interleukin-6 and tumour necrosis factor-alpha in vitro is reduced in whole blood of severely malnourished children. Clin Sci. 1994;83:347–51.
32.
Kammüller M, Ryffel B. Extrapolation of experimental safety data to humans: the interleukin-6 case. Clin Immunol Immunopathol. 2000;83:15–7.CrossRef
33.
Taga K, Tosato G. IL-10 inhibits human T cell proliferation and IL-2 production. J Immunol. 1991;148:2154–8.
34.
de Waal Malefyt R, Yssel H, Roncarolo M, Spits H, de Vries Jan E. Interleukin-10. Curr Opin Immunol. 1993;4:314–20.CrossRef
Metadata
Title
Expression of Cytokine mRNA in Lymphocytes of Malnourished Children
Authors
Haydeé González-Martínez
Leonor Rodríguez
Oralia Nájera
David Cruz
Angel Miliar
Aarón Domínguez
Fausto Sánchez
Jaime Graniel
María Cristina González-Torres
Publication date
01-09-2008
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 5/2008
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-008-9204-5

Other articles of this Issue 5/2008

Journal of Clinical Immunology 5/2008 Go to the issue

OriginalPaper

Decreased DNA Methyltransferase 3A and 3B mRNA Expression in Peripheral Blood Mononuclear Cells and Increased Plasma SAH Concentration in Adult Patients with Idiopathic Thrombocytopenic Purpura

OriginalPaper

Single Nucleotide Polymorphism in DNMT3B Promoter and the Risk for Idiopathic Thrombocytopenic Purpura in Chinese Population

OriginalPaper

Increased Granulysin Expression in Peripheral Blood Cells of Patients with Primary Biliary Cirrhosis and Its Clinical Implications

OriginalPaper

Elevated Serum Anti-Saccharomyces cerevisiae, Anti-I2 and Anti-OmpW Antibody Levels in Patients with Suspicion of Celiac Disease

Original Paper

Use of Sirolimus in IPEX and IPEX-Like Children

OriginalPaper

Sodium Tanshinone IIA Sulfonate Protects Mice From ConA-Induced Hepatitis via Inhibiting NF-κB and IFN-γ/STAT1 Pathways
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits