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01-09-2007

Association of HLA DQ B1^* and HLA DR B1^* Alleles with Goitrous Juvenile Autoimmune Hypothyroidism—A Case Control Study

Authors: Rekha P. L., Vijayalakshmi Valluri, Shilpa S. Rakh, Vinod Pantula, M. ISHAQ

Published in: Journal of Clinical Immunology | Issue 5/2007

Abstract

The present study was designed to analyze the distribution of HLA DQ B1^* and DR B1^* in patients with goitrous juvenile autoimmune hypothyroidism from Hyderabad, India. Analysis indicated an increase in the frequencies of HLA DQ B1^* 03 allele (P < 0.000) and HLA DR B1^* 04 (P < 0.05) alleles in this group of patients when compared to the controls, whereas the frequency of DQB1^*05 was found to be decreased in patients’ group compared to the controls (p < 0.01). To conclude, we report a positive correlation between DQ B1^* 03 and DR B1^* 04 and goitrous juvenile autoimmune hypothyroidism, whereas DQB1^*05 is observed to be negatively correlated with this thyroid dysfunction. Since the disease-susceptible HLA class II alleles appear to differ in various ethnic groups for some autoimmune diseases, the observed association from Indian series of patients holds significance.

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Title: Association of HLA DQ B1* and HLA DR B1* Alleles with Goitrous Juvenile Autoimmune Hypothyroidism—A Case Control Study
Authors: Rekha P. L.
Vijayalakshmi Valluri
Shilpa S. Rakh
Vinod Pantula
M. ISHAQ
Publication date: 01-09-2007
Publisher: Springer US
Published in: Journal of Clinical Immunology / Issue 5/2007
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-007-9102-2

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