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Journal of Interventional Cardiac Electrophysiology

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01-01-2021 | Atrial Fibrillation | Reviews

Second-generation cryoballoon vs. contact-force sensing radiofrequency catheter ablation in atrial fibrillation: a meta-analysis of randomized controlled trials

Authors: Yang Wang, Wei Wang, Jianming Yao, Lianghua Chen, Shaolei Yi

Published in: Journal of Interventional Cardiac Electrophysiology | Issue 1/2021

Abstract

Objectives

It is imperative to understand the influence of second-generation cryoballoon (CB-2) and contact-force sensing radiofrequency ablation (CF-RF) on clinical outcomes in atrial fibrillation (AF). This updated meta-analysis of randomized controlled trials (RCTs) examined the efficacy and safety of CB-2 vs. CF-RF in patients with AF.

Methods

RCTs on the use of CB-2 vs. CF-RF in patients with AF were included. The primary outcome was the recurrence of AF, and the key secondary outcomes included serious complications, acute pulmonary vein isolation (PVI), procedure duration, and fluoroscopy time.

Results

A total of 261 articles were identified, and five studies with a total of 845 participants were included in the study. A total of 93% of participants had paroxysmal AF, 7% of participants had persistent AF, and none of participants had permanent AF. There were 499 participants in the CB-2 arm and 346 in the CF-RF arm. AF recurrence was comparable in the CB-2 group (30.3%) and the CF-RF group (29.2%) (OR = 0.93; 95%CI = 0.56–1.54; P = 0.79; I² = 48%). There were no statistical differences in acute PVI (P = 0.92; I² = 0%) and serious complications (P = 0.87; I² = 47%) between the two groups. The procedure duration was shorter in the CB-2 group than in the CF-RF group (MD = − 13.39; 95%CI = − 15.58, − 7.19; P < 0.0001; I² = 59%).

Conclusion

Our study demonstrated that CB-2 and CF-RF had comparable recurrences of AF and similar incidences of serious complications in AF patients during the ablation process.

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Title: Second-generation cryoballoon vs. contact-force sensing radiofrequency catheter ablation in atrial fibrillation: a meta-analysis of randomized controlled trials
Authors: Yang Wang
Wei Wang
Jianming Yao
Lianghua Chen
Shaolei Yi
Publication date: 01-01-2021
Publisher: Springer US
Keyword: Atrial Fibrillation
Published in: Journal of Interventional Cardiac Electrophysiology / Issue 1/2021
Print ISSN: 1383-875X
Electronic ISSN: 1572-8595
DOI: https://doi.org/10.1007/s10840-020-00893-w

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Conclusion

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