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Journal of Interventional Cardiac Electrophysiology

Published in:

01-08-2014

Effects of radiofrequency catheter ablation on left ventricular structure and function in patients with atrial fibrillation: a meta-analysis

Authors: Pengju Zhu, Yong Zhang, Peiqing Jiang, Zhongsu Wang, Jiangrong Wang, Xiangcui Yin, Yinglong Hou

Published in: Journal of Interventional Cardiac Electrophysiology | Issue 2/2014

Abstract

Introduction

Radiofrequency catheter ablation (RFCA) is an effective therapy for atrial fibrillation (AF). This study was designed to investigate the effects of RFCA on left ventricular (LV) structure and function in AF patients.

Methods and Results

A systematic literature search in MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials was performed to identify trials involving changes of LV structure and function in AF patients undergoing RFCA. Effect size was expressed as weighted mean difference (WMD) with 95 % confidence interval (CI). LV end-diastolic diameter (LVEDD), LV end-systolic diameter (LVESD), LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), and LV ejection fraction (LVEF) were estimated. A total of 21 trials including 1,135 participants were qualified for this meta-analysis. Compared to the baseline values, there were significant decreases in LVEDV (WMD, −6.39 ml; 95 %CI, −12.46 to −0.33) and LVESV (WMD, −6.39 ml; 95 %CI, −11.35 to −1.42) and a significant improvement in LVEF (WMD, 6.23 %; 95 %CI, 3.70 to 8.75), but no significant changes were observed in LVEDD (WMD, −0.64 mm; 95 %CI, −2.40 to 1.13) and LVESD (WMD, −0.38 mm; 95 %CI, −1.32 to 0.56) after RFCA. Subgroup analysis demonstrated that patients with low LVEF (WMD, 11.90 %; 95 %CI, 9.16 to 14.64) gained more benefits than those with normal LVEF (WMD, 1.56 %; 95 %CI, 0.38 to 2.74). Besides, patients with chronic AF (WMD, 10.96 %; 95 %CI, 4.92 to 17.01) improved more than those with paroxysmal AF (WMD, 1.93 %; 95 %CI, −0.27 to 4.12).

Conclusions

RFCA in AF patients could reverse LV structural remodeling and improve LV systolic function, especially in patients with low LVEF and chronic AF.

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Title: Effects of radiofrequency catheter ablation on left ventricular structure and function in patients with atrial fibrillation: a meta-analysis
Authors: Pengju Zhu
Yong Zhang
Peiqing Jiang
Zhongsu Wang
Jiangrong Wang
Xiangcui Yin
Yinglong Hou
Publication date: 01-08-2014
Publisher: Springer US
Published in: Journal of Interventional Cardiac Electrophysiology / Issue 2/2014
Print ISSN: 1383-875X
Electronic ISSN: 1572-8595
DOI: https://doi.org/10.1007/s10840-014-9903-1

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