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Journal of Interventional Cardiac Electrophysiology

Published in:

01-03-2010

Fatty acid percentage in erythrocyte membranes of atrial flutter/fibrillation patients and controls

Authors: Chiara Viviani Anselmi, Carla Ferreri, Valeria Novelli, Roberta Roncarati, Roberta Bronzini, Giovanni Marchese, Francesco Somalvico, Gianluigi Condorelli, Annibale Sandro Montenero, Annibale Alessandro Puca

Published in: Journal of Interventional Cardiac Electrophysiology | Issue 2/2010

Abstract

Purpose

Several epidemiological published data support the protective role of omega-3 consumption in coronary artery disease, sudden cardiac death and ventricular arrhythmias, but interestingly, this is not the case for atrial arrhythmias. The purpose of this study is to evaluate different fatty acid profile between AF/AFL subjects and healthy controls.

Methods

Gas chromatography was employed to determine fatty acid percentage of erythrocyte membranes from 40 idiopathic AFL/AF patients and 53 healthy control subjects.

Results

AFL/AF erythrocyte membranes had significantly lower percentage of saturated fatty acid (43.1 ± SD2.2 versus 47.8 ± SD9.6, p < 0.001), monounsaturated fatty acid (18.2 ± SD2.5 versus 22.6 ± SD5.2, p < 0.001) and total trans fatty acid (0.2 ± SD0.1 vs 1.3 ± SD1.1, p < 0.001) than controls. Furthermore, fatty acid (FA) profiles of arrhythmic individuals showed an increased percent of total polyunsaturated fatty acid (PUFA) (36.7 ± SD2.4 versus 26.4 ± SD10.4, p < 0.001), PUFA n-3 (5.3 ± SD1.1 versus 2.8 ± SD1.8, p < 0.001) and n-6 (31.4 ± SD2.2 versus 23.5 ± SD9.9, p < 0.001).

Conclusion

This study shows that the erythrocyte membranes FA composition of AF/AFL subjects differs from that of healthy controls

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Title: Fatty acid percentage in erythrocyte membranes of atrial flutter/fibrillation patients and controls
Authors: Chiara Viviani Anselmi
Carla Ferreri
Valeria Novelli
Roberta Roncarati
Roberta Bronzini
Giovanni Marchese
Francesco Somalvico
Gianluigi Condorelli
Annibale Sandro Montenero
Annibale Alessandro Puca
Publication date: 01-03-2010
Publisher: Springer US
Published in: Journal of Interventional Cardiac Electrophysiology / Issue 2/2010
Print ISSN: 1383-875X
Electronic ISSN: 1572-8595
DOI: https://doi.org/10.1007/s10840-009-9466-8

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Fatty acid percentage in erythrocyte membranes of atrial flutter/fibrillation patients and controls

Abstract

Purpose

Methods

Results

Conclusion

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