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Journal of Interventional Cardiac Electrophysiology

Published in:

01-11-2008

Presence of left ventricular contractile reserve, evaluated by means of dobutamine stress-echo test, is able to predict response to cardiac resynchronization therapy

Authors: Bernardino Tuccillo, Carmine Muto, Raffaele Iengo, Maria Accadia, Salvatore Rumolo, Micheleangelo Canciello, Giovanni Carreras, Raimondo Calvanese, Eduardo Celentano, Mario Davinelli, Sergio Valsecchi, Luigi Ascione

Published in: Journal of Interventional Cardiac Electrophysiology | Issue 2/2008

Abstract

Introduction

We evaluated whether the dobutamine stress-echo test can select responders to cardiac resynchronization therapy (CRT). Up to 50% of patients do not respond to CRT. Lack of response may be due to a significant amount of scar or fibrotic tissue at myocardial level.

Methods and Results

We studied 42 CRT patients. After clinical and echocardiographic evaluation, all patients underwent a dobutamine stress-echo test to assess contractile reserve. Cut-off for the test was an increase of 25% of the left ventricular ejection fraction. Patients were implanted with a CRT–defibrillator and followed up at 6 months. Cut-off for CRT response was a reduction of 15% of left ventricular end-systolic volume. Twenty-five patients responded to CRT; all of them showed presence of contractile reserve. The test showed a sensitivity of 100% and a specificity of 88%.

Conclusion

Contractile reserve was a strong predictive factor of response to CRT in the studied population.

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Title: Presence of left ventricular contractile reserve, evaluated by means of dobutamine stress-echo test, is able to predict response to cardiac resynchronization therapy
Authors: Bernardino Tuccillo
Carmine Muto
Raffaele Iengo
Maria Accadia
Salvatore Rumolo
Micheleangelo Canciello
Giovanni Carreras
Raimondo Calvanese
Eduardo Celentano
Mario Davinelli
Sergio Valsecchi
Luigi Ascione
Publication date: 01-11-2008
Publisher: Springer US
Published in: Journal of Interventional Cardiac Electrophysiology / Issue 2/2008
Print ISSN: 1383-875X
Electronic ISSN: 1572-8595
DOI: https://doi.org/10.1007/s10840-008-9255-9

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