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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 12/2023

11-10-2023 | Premature Birth | Assisted Reproduction Technologies

Perinatal outcomes in 6640 singleton pregnancies after donor oocyte IVF across three continents over 7 years

Authors: Jaimin S. Shah, Francesc Figueras, Anna Blàzquez, Sarai Brazal, Jose Buratini, Rafael Buscà, Mariabeatrice Dal Canto, Roberta Iemmello, Catherine K. Jacobs, Aline R. Lorenzon, Mario Mignini Renzini, Maider Ripero, Denny Sakkas

Published in: Journal of Assisted Reproduction and Genetics | Issue 12/2023

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Abstract

Purpose

Are trends in singleton donor oocyte IVF perinatal outcomes consistent over time among four international ethnically diverse infertility centers?

Methods

This retrospective cohort consisted of an infertility network of four international IVF centers across three continents. Singleton live births resulting from fresh and frozen donor oocyte embryo transfers from January 1, 2012 to December 31, 2018 were included. The main outcome measures were birth weight (BW), preterm birth (PTB), large for gestational age (LGA), small for gestational age (SGA) and gestational age (GA) at delivery.

Results

The entire cohort (n = 6640) consisted of 4753 fresh and 1887 frozen donor oocyte embryo transfers. Maternal age, parity, body mass index, neonatal sex and GA at delivery were similar for fresh and frozen donor oocyte embryo transfers in the entire cohort and within each infertility center. All four centers had a trend of decreased BW and rates of PTB before 32 weeks annually, although significance was not reached. Three of the four centers had annual increased trends of PTB before 37 weeks and LGA newborns, although significance was not reached. BWs for the entire cohort for fresh and frozen donor embryo transfers were 3166 g ± 601 g and 3137 g ± 626 g, respectively.

Conclusion

Similar trends in perinatal outcomes were present across four international infertility centers over 7 years. The overall perinatal trends in donor oocyte IVF may be applicable to centers worldwide, but further studies in more geographic regions are needed.
Appendix
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Metadata
Title
Perinatal outcomes in 6640 singleton pregnancies after donor oocyte IVF across three continents over 7 years
Authors
Jaimin S. Shah
Francesc Figueras
Anna Blàzquez
Sarai Brazal
Jose Buratini
Rafael Buscà
Mariabeatrice Dal Canto
Roberta Iemmello
Catherine K. Jacobs
Aline R. Lorenzon
Mario Mignini Renzini
Maider Ripero
Denny Sakkas
Publication date
11-10-2023
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 12/2023
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-023-02965-y

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