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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 6/2020

Open Access 01-06-2020 | Fertility | Review

Impact of contraception and IVF hormones on metabolic, endocrine, and inflammatory status

Authors: Ayla Coussa, Hayder A. Hasan, Thomas M. Barber

Published in: Journal of Assisted Reproduction and Genetics | Issue 6/2020

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Abstract

Assisted reproductive technologies (ART) represent commonly utilized management strategies for infertility with multifactorial causes (including genetically predisposed diseases). Amongst ART, in vitro fertilization (IVF) is the most popular. IVF treatment may predispose the mother to increased risks and complications during pregnancy, and there may be adverse fetal outcomes. Hormonal therapies, including oral contraceptives, may impair glucose and lipid metabolism, and promote insulin resistance and inflammation. IVF treatment involves administration of reproductive hormones, similar in composition but in much higher doses than those used for oral contraception. The provision of IVF reproductive hormones to mice associates with glucose intolerance. In addition, the physiological and hormonal changes of pregnancy can trigger an inflammatory response, and metabolic and endocrine changes. There is controversy regarding the potential effects of IVF hormonal therapies in the promotion of diabetogenic and inflammatory states, additional to those that occur during pregnancy, and which may therefore predispose women with IVF-conceived pregnancies to adverse obstetric outcomes compared with women with spontaneously conceived pregnancies. This review summarizes the limited published evidence regarding the effect of IVF-based fertility therapies on glucose homeostasis, insulin resistance, cardio-metabolic profile, and markers of inflammation.
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Metadata
Title
Impact of contraception and IVF hormones on metabolic, endocrine, and inflammatory status
Authors
Ayla Coussa
Hayder A. Hasan
Thomas M. Barber
Publication date
01-06-2020
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 6/2020
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-020-01756-z

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