Top

Journal of Assisted Reproduction and Genetics

Published in:

01-04-2018 | Assisted Reproduction Technologies

Dehydroepiandrosterone (DHEA) supplementation: an underappreciated cause of premature progesterone elevation detected during frozen embryo transfer

Authors: Frank Shao-Ying Wu, Shao-Ping Weng, Meng-Shun Shen

Published in: Journal of Assisted Reproduction and Genetics | Issue 4/2018

Excerpt

The negative impacts of late follicular elevation of serum progesterone (P) on the clinical outcome of fresh embryo transfers (ET) have been well established [1, 2]. The main detriment of premature P elevation is impaired endometrial receptivity, specifically, the asynchrony between the endometrium and the developing embryos [3, 4]. Therefore, frozen embryo transfer (FET) was almost universally offered to patients in the event of premature P elevation with encouraging outcomes, indicating that follicular P exposure confers no significant impact to the quality of oocyte and the derived embryos [5, 6]. …

Venetis CA, Kolibianakis EM, Bosdou JK, Tarlatzis BC. Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60 000 cycles. Hum Reprod Update. 2013;19(5):433–57.CrossRefPubMed

Bosch E, Labarta E, Crespo J, Simón C, Remohí J, Jenkins J, et al. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod. 2010;25(8):2092–100.CrossRefPubMed

Bourgain C, Ubaldi F, Tavaniotou A, Smitz J, Van Steirteghem AC, Devroey P. Endometrial hormone receptors and proliferation index in the periovulatory phase of stimulated embryo transfer cycles in comparison with natural cycles and relation to clinical pregnancy outcome. Fertil Steril. 2002;78(2):237–44.CrossRefPubMed

Lawrenz B, Fatemi HM. Effect of progesterone elevation in follicular phase of IVF-cycles on the endometrial receptivity. Reprod BioMed Online. 2017;34(4):422–8.CrossRefPubMed

Yang S, Pang T, Li R, Yang R, Zhen X, Chen X, et al. The individualized choice of embryo transfer timing for patients with elevated serum progesterone level on the HCG day in IVF/ICSI cycles: a prospective randomized clinical study. Gynecol Endocrinol. 2015;31(5):355–8.CrossRefPubMed

Healy MW, Patounakis G, Connell MT, Devine K, DeCherney AH, Levy MJ, et al. Does a frozen embryo transfer ameliorate the effect of elevated progesterone seen in fresh transfer cycles? Fertil Steril. 2016;105(1):93–9.e1.CrossRefPubMed

Al-Azemi M, Kyrou D, Kolibianakis EM, Humaidan P, Van Vaerenbergh I, Devroey P, et al. Elevated progesterone during ovarian stimulation for IVF. Reprod BioMed Online. 2012;24(4):381–8.CrossRefPubMed

Bosch E, Valencia I, Escudero E, Crespo J, Simón C, Remohí J, et al. Premature luteinization during gonadotropinreleasing hormone antagonist cycles and its relationship with in vitro fertilization outcome. Fertil Steril. 2003;80(6):1444–9.CrossRefPubMed

Ubaldi F, Albano C, Peukert M, Riethmuller-Winzen H, Camus M, Smitz J, et al. Subtle progesterone rise after the administration of the gonadotrophin-releasing hormone antagonist cetrorelix in intracytoplasmic sperm injection cycles. Hum Reprod. 1996;11(7):1405–7.CrossRefPubMed

10.

Kyrou D, Al-Azemi M, Papanikolaou EG, Donoso P, Tziomalos K, Devroey P, et al. The relationship of premature progesterone rise with serum estradiol levels and number of follicles in GnRH antagonist/recombinant FSH-stimulated cycles. Eur J Obstet Gynecol Reprod Biol. 2012;162(2):165–8.CrossRefPubMed

11.

Lawrenz B, Beligotti F, Engelmann N, Gates D, Fatemi HM. Impact of gonadotropin type on progesterone elevation during ovarian stimulation in GnRH antagonist cycles. Hum Reprod. 2016;31(11):2554–60.CrossRefPubMed

12.

Franasiak JM, Thomas S, Ng S, Fano M, Ruiz A, Scott RT Jr, et al. Dehydroepiandrosterone (DHEA) supplementation results in supraphysiologic DHEA-S serum levels and progesterone assay interference that may impact clinical management in IVF. J Assist Reprod Genet. 2016;33(3):387–91.CrossRefPubMedPubMedCentral

13.

Patrizio P, Vaiarelli A, Levi Setti PE, Tobler KJ, Shoham Z, Leong M, et al. How to define, diagnose and treat poor responders? Responses from a worldwide survey of IVF clinics. Reprod BioMed Online. 2015;30(6):581–92.CrossRefPubMed

14.

Ubaldi F, Smitz J, Wisanto A, Joris H, Schiettecatte J, Derde MP, et al. Oocyte and embryo quality as well as pregnancy rate in intracytoplasmic sperm injection are not affected by high follicular phase serum progesterone. Hum Reprod. 1995;10(12):3091–6.CrossRefPubMed

15.

Givens CR, Schriock ED, Dandekar PV, Martin MC. Elevated serum progesterone levels on the day of human chorionic gonadotropin administration do not predict outcome in assisted reproduction cycles. Fertil Steril. 1994;62(5):1011–7.CrossRefPubMed

16.

Pluchino N, Ninni F, Stomati M, Freschi L, Casarosa E, Valentino V, et al. One-year therapy with 10 mg/day DHEA alone or in combination with HRT in postmenopausal women: effects on hormonal milieu. Maturitas. 2008;59(4):293–303.CrossRefPubMed

17.

Strauss S, Greve T, Ernst E, Fraidakis M, Grudzinkas JG, Andersen CY. Administration of DHEA augments progesterone production in a woman with low ovarian reserve being transplanted with cryopreserved ovarian tissue. J Assist Reprod Genet. 2014;31:645–9.CrossRefPubMedPubMedCentral

18.

Weissman A, Horowitz E, Ravhon A, Golan A, Levran D. Dehydroepiandrosterone supplementation increases baseline follicular phase progesterone levels. Gynecol Endocrinol. 2011;27:1014–7.CrossRefPubMed

Title: Dehydroepiandrosterone (DHEA) supplementation: an underappreciated cause of premature progesterone elevation detected during frozen embryo transfer
Authors: Frank Shao-Ying Wu
Shao-Ping Weng
Meng-Shun Shen
Publication date: 01-04-2018
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 4/2018
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-018-1116-6

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Dehydroepiandrosterone (DHEA) supplementation: an underappreciated cause of premature progesterone elevation detected during frozen embryo transfer

Excerpt

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 4/2018

Not many shoulders of giants to stand on these days

Sperm telomere length in donor samples is not related to ICSI outcome

Psychosocial benefits of fertility preservation for young cancer patients

Variation analysis of PUM1 gene in Chinese women with primary ovarian insufficiency

Preliminary human application of optical coherence tomography for quantification and localization of primordial follicles aimed at effective ovarian tissue transplantation