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Journal of Assisted Reproduction and Genetics

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01-12-2016 | Letter to the Editor

Oxidative stress and the etiology of male infertility

Author: R. J. Aitken

Published in: Journal of Assisted Reproduction and Genetics | Issue 12/2016

Excerpt

One of the few insights we have gained into the etiology of male infertility over the past 20 years has been the realization that these cells, and the precious cargos they carry, are extremely vulnerable to oxidative stress [1]. Furthermore, the fact that antioxidant therapy seems to have a beneficial impact on semen quality suggests that such stress does not just correlate with defective sperm function but is causally involved in its genesis [2, 3]. However, one of the fundamental questions that remains is the actual mechanism by which reactive oxygen species (ROS) are generated in cases male infertility. …

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Showell MG, Mackenzie-Proctor R, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. Cochrane Database Syst Rev. 2014;12:CD007411.

Jiang L, Zheng T, Huang J, Mo J, Zhou H, Liu M, et al. Association of semen cytokines with reactive oxygen species and histone transition abnormalities. J Assist Reprod Genet. 2016. doi:10.1007/s10815-016-0756-7.PubMedCentral

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De Iuliis GN, Thomson LK, Mitchell LA, Finnie JM, Koppers AJ, Hedges A, et al. DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2′-deoxyguanosine, a marker of oxidative stress. Biol Reprod. 2009;81(3):517–24.CrossRefPubMed

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11.

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Koppers AJ, De Iuliis GN, Finnie JM, McLaughlin EA, Aitken RJ. Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa. J Clin Endocrinol Metab. 2008;93(8):3199–207.CrossRefPubMed

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Musset B, Clark RA, DeCoursey TE, Petheo GL, Geiszt M, Chen Y, Cornell JE, Eddy CA, Brzyski RG, El Jamali A. NOX5 in human spermatozoa: expression, function, and regulation. J Biol Chem. 2012;16;287(12):9376–88.

14.

Pelliccione F, D’Angeli A, Cordeschi G, Mihalca R, Ciociola F, Necozione S, et al. Francavilla seminal macrophages in ejaculates from men with couple infertility. Int J Androl. 2009;32(6):623–8.CrossRefPubMed

Title: Oxidative stress and the etiology of male infertility
Author: R. J. Aitken
Publication date: 01-12-2016
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 12/2016
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-016-0791-4

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