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Journal of Assisted Reproduction and Genetics

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01-08-2016 | Reproductive Physiology and Disease

Seminal plasma HSPA2 mRNA content is associated with semen quality

Authors: Yonghong Tian, Lejun Li, Fengbin Zhang, Jian Xu

Published in: Journal of Assisted Reproduction and Genetics | Issue 8/2016

Abstract

Purpose

Cell-free mRNAs (cfmRNAs) were quantitatively measured in human seminal plasma and its relationship with semen quality was investigated.

Methods

Herein, a prospectively, controlled investigation was performed to study seminal plasma HSPA2 and uPA cfmRNA alterations between 21 asthenozoospermic patients and 16 normozoospermic individuals. Standard semen analysis was performed and seminal plasma cfmRNAs content was measured by real-time quantitative PCR. In addition, the regression analysis between seminal plasma cfmRNAs expression and semen parameters was performed.

Results

Seminal plasma HSPA2, but not uPA cfmRNA indicated significant difference between normozoospermia and asthenozoospermia men (P = 0.02444 and 0.07811, respectively). Negative correlation between HSPA2 cfmRNA and sperm motility (R ² = 0.213, P = 0.004) as well as sperm concentration (R ² = 0.133, P = 0.026) were revealed. However, no correlation was found between seminal plasma uPA cfmRNA content and semen parameters.

Conclusions

Our data suggest that seminal plasma HSPA2 cfmRNA is different between asthenozoospermic and normozoospermic individuals and it might be an indicator for semen quality.

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Title: Seminal plasma HSPA2 mRNA content is associated with semen quality
Authors: Yonghong Tian
Lejun Li
Fengbin Zhang
Jian Xu
Publication date: 01-08-2016
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 8/2016
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-016-0730-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Seminal plasma HSPA2 mRNA content is associated with semen quality

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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