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Journal of Assisted Reproduction and Genetics

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01-07-2016 | Genetics

Association of interleukin-10 gene promoter polymorphisms with recurrent pregnancy loss: a meta-analysis

Authors: Chongjuan Gu, Hongxia Gong, Zheng Zhang, Zhao Yang, Yongxin Ma

Published in: Journal of Assisted Reproduction and Genetics | Issue 7/2016

Abstract

Purpose

It has been reported single-nucleotide polymorphisms (SNPs) of the IL-10 promoter might be associated with the susceptibility to recurrent pregnancy loss (RPL). Owing to the inconclusive results, we conducted a meta-analysis to systematically summarize and clarify the association between the IL-10 promoter SNPs and RPL risk.

Methods

A systematic search of studies on the association of the three SNPs with RPL was conducted in PubMed and Embase. Odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were used to pool the effect size.

Result

Eleven case–control studies on rs1800896, seven studies on rs1800871, and eight studies on rs1800872 were included. A significant association was identified between IL-10 rs1800896 with RPL risk (G versus A: OR = 1.21, 95 % CI 1.09–1.35). No evidence of association was found between rs1800871 and RPL when restricted to those studies in Hardy–Weinberg equilibrium in controls (T versus C: OR = 1.25, 95 % CI 0.76–2.06). No statistical association was demonstrated between rs1800872 and RPL (C versus A: OR = 1.08, 95 % CI 0.83–1.42).

Conclusions

IL-10 rs1800896 significantly increases the risk of RPL, while rs1800872 is not correlated with RPL risk. No significant association is demonstrated between rs1800871 and RPL risk but this requires further investigation.

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Title: Association of interleukin-10 gene promoter polymorphisms with recurrent pregnancy loss: a meta-analysis
Authors: Chongjuan Gu
Hongxia Gong
Zheng Zhang
Zhao Yang
Yongxin Ma
Publication date: 01-07-2016
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 7/2016
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-016-0699-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Association of interleukin-10 gene promoter polymorphisms with recurrent pregnancy loss: a meta-analysis

Abstract

Purpose

Methods

Result

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Result

Conclusions

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