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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 7/2016

01-07-2016 | Review

Immunogenetic contributions to recurrent pregnancy loss

Authors: Frances Grimstad, Sacha Krieg

Published in: Journal of Assisted Reproduction and Genetics | Issue 7/2016

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Abstract

While sporadic pregnancy loss is common, occurring in 15 % of pregnancies, recurrent pregnancy loss (RPL) impacts approximately 5 % of couples. Though multiple causes are known (including structural, hormonal, infectious, autoimmune, and thrombophilic causes), after evaluation, roughly half of all cases remain unexplained. The idiopathic RPL cases pose a challenging therapeutic dilemma in addition to incurring much physical and emotional morbidity. Immunogenetic causes have been postulated to contribute to these cases of RPL. Natural Killer cell, T cell expression pattern changes in the endometrium have both been shown in patients with RPL. Human leukocyte antigen (HLA) and cytokine allelic variations have also been studied as etiologies for RPL. Some of the results have been promising, however the studies are small and have not yet put forth outcomes that would change our current diagnosis and management of RPL. Larger database studies are needed with stricter control criteria before reasonable conclusions can be drawn.
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Metadata
Title
Immunogenetic contributions to recurrent pregnancy loss
Authors
Frances Grimstad
Sacha Krieg
Publication date
01-07-2016
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 7/2016
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-016-0720-6

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