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International Ophthalmology

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01-06-2020 | Uveitis | Original Paper

Choroid vascularity index as a parameter for chronicity of Fuchs’ uveitis syndrome

Authors: Muhammet Derda Ozer, Muhammed Batur, Serek Tekin, Erbil Seven, Fatih Kebapci

Published in: International Ophthalmology | Issue 6/2020

Abstract

Purpose

This study aimed to compare the choroidal vascularity index (CVI) of eyes having Fuchs’ uveitis syndrome (FUS) with healthy fellow eyes (N).

Methods

This prospective, cross-sectional study included unilateral FUS cases and an age- and gender-matched healthy control group. Thirty-nine participants were included in the FUS group, and 24 age- and gender-matched individuals were randomly selected for the control group. Endothelial cell density (ECD) was measured using Tomey specular microscopy. Spectral-domain optical coherence tomography was used to acquire the choroidal images, and binarization was applied to the images. Two blinded investigators analyzed the CVI in both eyes of the FUS cases and the right eyes of the healthy control group.

Results

CVI was found to be significantly decreased in FUS (p < 0.001). Additionally, ECD had a strong positive correlation with CVI (r = 0.383, p = 0.008).

Conclusion

CVI may provide information about the chronicity of the disease.

Kazokoglu H, Onal S, Tugal-Tutkun I, Mirza E, Akova Y, Ozyazgan Y et al (2008) Demographic and clinical features of uveitis in tertiary centers in Turkey. Ophthalmic Epidemiol 15:285–293CrossRef

Rathinam SR, Namperumalsamy P (2007) Global variation and pattern changes in epidemiology of uveitis. Indian J Ophthalmol 55:173–183CrossRef

Basarir B, Altan C, Pinarci EY, Celik U, Satana B, Demirok A (2013) Analysis of iris structure and iridocorneal angle parameters with anterior segment optical coherence tomography in Fuchs’ uveitis syndrome. Int Ophthalmol 33:245–250CrossRef

Kimura SJ, Hogan MJ, Thygeson P (2005) Fuchs’ syndrome of heterochromic cyclitis. Arch Ophthalmol 54(2):179–186CrossRef

Bonfioli AA, Curi AL, Orefice F (2005) Fuchs’ heterochromic cyclitis. Semin Ophthalmol. 20(3):143–146CrossRef

Mohamed Q, Zamir E (2005) Update on Fuchs’ uveitis syndrome. Curr Opin Ophthalmol 16:356–363CrossRef

Kardes E, Sezgin Akcay BI, Unlu C, Ergin A (2017) Choroidal thickness in eyes with Fuchs Uveitis Syndrome. Ocul Immunol Inflamm. 25(2):259–266CrossRef

Agrawal A, Agarwal R, Khandelwal N, Invernizzi A, Aggarwal K, Sharma A et al (2018) Choroidal structural changes in tubercular multifocal serpiginoid choroiditis. Ocul Immunol Inflamm 26(6):838–844CrossRef

Agrawal R, Chhablani J, Tan KA, Shah S, Sarvaiya C, Banker A (2016) Choroidal vascularity index in central serous chorioretinopathy. Retina. 36:1646–1651CrossRef

10.

Agrawal R, Li LKH, Nakhate V, Khandelwal N, Mahendradas P (2016) Choroidal vascularity index in Vogt-Koyanagi–Harada disease: an EDI-OCT derived tool for monitoring disease progression. Transl Vis Sci Technol 5(4):7CrossRef

11.

Agrawal R, Salman M, Tan KA, Karampelas M, Sim DA, Keane PA et al (2016) Choroidal vascularity index (CVI)-a novel optical coherence tomography parameter for monitoring patients with panuveitis? PLoS One 11(1):e0146344CrossRef

12.

Ratra D, Tan R, Jaishankar D, Khandelwal N, Gupta A, Chhablani J et al (2018) Choroıdal structural changes and vascularıty ındex ın stargardt dısease on swept source optıcal coherence tomography. Retina 38(12):2395–2400PubMed

13.

Tan KA, Laude A, Yip V, Loo E, Wong EP, Agrawal R (2016) Choroidal vascularity index–a novel optical coherence tomography parameter for disease monitoring in diabetes mellitus? Acta Ophthalmol 94(7):e612–e616CrossRef

14.

Tan R, Agrawal R, Taduru S, Gupta A, Vupparaboina K, Chhablani J (2018) Choroidal vascularity index in retinitis pigmentosa: an OCT study. Ophthalmic Surg Lasers Imaging Retina. 49(3):191–197CrossRef

15.

Wei X, Ting DSW, Ng WY, Khandelwal N, Agrawal R, Cheung CMG (2017) Choroidal vascularity index: a novel optical coherence tomography based parameter in patients with exudative age-related macular degeneration. Retina 37(6):1120–1125CrossRef

16.

Ağın A, Kadayıfçılar S, Sönmez HE, Baytaroglu A, Demir S, Sag E et al (2019) Evaluation of choroidal thickness, choroidal vascularity index and peripapillary retinal nerve fiber layer in patients with juvenile systemic lupus erythematosus. Lupus 28(1):44–50CrossRef

17.

Kurt A, Kurt EE, Kilic R, Oktem C, Tuncay F, Erdem HR (2017) Is choroidal thickness related with disease activity and joint damage in patient with rheumatoid arthritis. Bratisl Lek Listy 118(1):23–27PubMed

18.

Balci O, Ozsutcu M (2016) Evaluation of retinal and choroidal thickness in Fuchs’ uveitis syndrome. J Ophthalmol. 2016:1657078CrossRef

19.

Invernizzi A, Cigada M, Savoldi L, Cavuto S, Fontana L, Cimino L (2014) In vivo analysis of the iris thickness by spectral domain optical coherence tomography. Br J Ophthalmol 98(9):1245–1249CrossRef

20.

Alfawaz AM, Holland GN, Yu F, Margolis MS, Giaconi JA, Aldave AJ (2016) Corneal endothelium in patients with anterior uveitis. Ophthalmology 123(8):1637–1645CrossRef

21.

Jabs DA, Nussenblatt RB, Rosenbaum JT (2005) Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol 140:509–516CrossRef

22.

Nussenblatt RB, Palestine AG, Chan CC, Roberge F (1985) Standardization of vitreal inflammatory activity in intermediate and posterior uveitis. Ophthalmology 92:467–471CrossRef

23.

Cerquaglia A, Iaccheri B, Fiore T, Lupidi M, Torroni G, Fruttini D et al (2016) Full-thickness choroidal thinning as a feature of Fuchs Uveitis Syndrome: quantitative evaluation of choroid by enhanced depth imaging optical coherence tomography in a cohort of consecutive patients. Graefes Arch Clin Exp Ophthalmol 254(10):2025–2031CrossRef

24.

Tugal-Tutkun I, Guney-Tefekli E, Kamaci-Duman F, Corum I (2009) A cross-sectional and longitudinal study of Fuchs uveitis syndrome in Turkish patients. Am J Ophthalmol 148(4):510–515CrossRef

25.

Koh LHL, Agrawal R, Khandelwal N, Sai Charan L, Chhablani J (2017) Choroidal vascular changes in age-related macular degeneration. Acta Ophthalmol 95:e597–e601CrossRef

26.

Szepessy Z, Toth G, Barsi A, Kranitz K, Nagy ZZ (2016) Anterior segment characteristics of Fuchs Uveitis Syndrome. Ocul Immunol Inflamm. 24(5):594–598CrossRef

27.

Huang Z, Wang XY, Liu L, Han W (2014) Corneal decompensation in bilateral Fuchs heterochromic uveitis. Can J Ophthalmol 49(1):e11–e14CrossRef

Title: Choroid vascularity index as a parameter for chronicity of Fuchs’ uveitis syndrome
Authors: Muhammet Derda Ozer
Muhammed Batur
Serek Tekin
Erbil Seven
Fatih Kebapci
Publication date: 01-06-2020
Publisher: Springer Netherlands
Keyword: Uveitis
Published in: International Ophthalmology / Issue 6/2020
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-020-01309-4

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Choroid vascularity index as a parameter for chronicity of Fuchs’ uveitis syndrome

Abstract

Purpose

Methods

Results

Conclusion

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Abstract

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