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Open Access 01-04-2020 | Stroke | Original Paper

Link of ocular pseudoexfoliation syndrome and vascular system changes: results from 10-year follow-up study

Authors: Ugnė Rumelaitienė, Dalia Žaliūnienė, Martynas Špečkauskas, Abdonas Tamošiūnas, Ričardas Radišauskas, Emilija Jusevičiūtė, Vidas Vainauskas, Gailutė Bernotienė

Published in: International Ophthalmology | Issue 4/2020

Abstract

Purpose

To examine the 10-year incidence of the pseudoexfoliation syndrome (PEX) in adults in a population-based follow-up study, to determine its link with vascular diseases, and to identify possible risk factors of the PEX.

Methods

The baseline examination was performed in 2006 on a random sample of 1033 participants from Kaunas city (Lithuania) population. In 2016, a follow-up study of 686 participants who returned for the examination was conducted. The respondents filled out a questionnaire, an ophthalmological examination was performed, and the presence of vascular diseases was determined by the anamnesis and electrocardiogram evaluation data. Binary univariate and multivariate logistic regression analyses were conducted with the PEX and vascular diseases as predictors, controlling for age. Odds ratios (OR) and 95% confidence intervals of OR were calculated for the risk of new PEX cases.

Results

During 10 years, the prevalence of the PEX in the study population increased from 10.3 to 34.2%. The rates of ischemic heart disease (IHD) and IHD combined with stroke were significantly higher in the PEX subjects than in the non-PEX subjects. The risk of the PEX among persons with IHD was, on the average, by 1.5-fold higher, and among those with IHD and stroke, on the average, by 1.6-fold higher as compared to persons without the aforementioned pathologies (accordingly, p = 0.014 and p = 0.010).

Conclusion

The prevalence of the PEX increased significantly with age. The risk of the PEX was significantly higher among persons with IHD and even higher among persons with IHD and stroke. In the future, a greater understanding of the cardiovascular, metabolic, and environmental components associated with the PEX may lead to more specific lifestyle-related preventive strategies to decrease the disease burden.

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Title: Link of ocular pseudoexfoliation syndrome and vascular system changes: results from 10-year follow-up study
Authors: Ugnė Rumelaitienė
Dalia Žaliūnienė
Martynas Špečkauskas
Abdonas Tamošiūnas
Ričardas Radišauskas
Emilija Jusevičiūtė
Vidas Vainauskas
Gailutė Bernotienė
Publication date: 01-04-2020
Publisher: Springer Netherlands
Keywords: Stroke
Hypertension
Arterial Hypertension
Arterial Hypertension
Published in: International Ophthalmology / Issue 4/2020
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-019-01262-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Link of ocular pseudoexfoliation syndrome and vascular system changes: results from 10-year follow-up study

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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