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International Ophthalmology
Published in: International Ophthalmology 1/2020

01-01-2020 | Retinoblastoma | Original Paper

Clinical presentation and outcome of retinoblastoma based on age at presentation: a review of 1450 children

Authors: Swathi Kaliki, Arpita Maniar, Anamika Patel, Vijay Anand Reddy Palkonda, Ashik Mohamed

Published in: International Ophthalmology | Issue 1/2020

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Abstract

Purpose

To compare the clinical presentation and outcomes of retinoblastoma (RB) based on age at presentation.

Methods

Retrospective comparative study of 1940 eyes of 1450 children with RB.

Results

Presentation of RB with enlarged eyeball and eyelid swelling (2% and < 1% in ≤ 1 year, 4% and 2% in > 1–2 years, 7% and 2% in > 2–3 years, and 12% and 4% in > 3 years; p < 0.0001 and p = 0.05, respectively) is more common with increasing age. Based on the 8th edition of American Joint Committee Classification, T1 is more common in children younger than 1 year (27%), while T4 is more common in children > 3 years of age (20%) (p < 0.0001). Kaplan–Meier (KM) estimate at 1 and 5 years for globe salvage was 64% and 58% in children ≤ 1 year of age versus 30% and 20% in children > 3 years, respectively [Hazard ratio (HR) = 2.48; p < 0.0001], and KM estimate at 1 and 5 years for life salvage was 99% and 97% in children ≤ 1 year of age versus 89% and 78% in children older than 3 years, respectively (HR = 7.65; p < 0.0001).

Conclusion

Uncommon clinical features of RB including enlarged eyeball and eyelid swelling are more common with increasing age. Younger age at presentation with RB is associated with better prognosis including higher chances of life and globe salvage.
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Metadata
Title
Clinical presentation and outcome of retinoblastoma based on age at presentation: a review of 1450 children
Authors
Swathi Kaliki
Arpita Maniar
Anamika Patel
Vijay Anand Reddy Palkonda
Ashik Mohamed
Publication date
01-01-2020
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 1/2020
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-019-01155-z

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