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International Ophthalmology
Published in: International Ophthalmology 1/2018

01-02-2018 | Original Paper

Characteristics of orbital lymphoma: a clinicopathological study of 26 cases

Authors: Daniel Briscoe, Christine Safieh, Yokrat Ton, Hava Shapiro, Ehud I. Assia, Dvora Kidron

Published in: International Ophthalmology | Issue 1/2018

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Abstract

Objective

Evaluation of the medical data of patients with orbital and adnexal lymphoma.

Design

Cohort study of all cases diagnosed with orbital or adnexal lymphoma at Meir Medical Center between 1993 and 2007.

Participants

Twenty-six patients, with intraorbital or subconjunctival masses with orbital involvement, were examined and followed up between 1 and 8 years.

Materials and methods

Examined data included: clinical presentation, age, gender, imaging, tumor location, surgical management, and pathological diagnosis.

Results

Presenting signs and symptoms included proptosis, eyelid lesions, tearing, chemosis, decreased visual acuity, ptosis, pain, squint, and optic nerve compression. In five cases, lymphoma was misdiagnosed on neuroimaging. Bone changes were seen in four patients. All cases were B cell lymphomas; with the majority (22 cases) of small B cell type; consisting of primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue and two cases of small cell lymphoma. One small cell lymphomas was of follicular type on a background of CLL, and the other was CLL/SLL type. Fourteen cases were primary orbital disease, and 12 cases were systemic disease. Macroscopic appearance of lymphoma at open biopsy was characteristic in most cases. Flow cytometry phenotyping gave rapid reliable diagnosis of the disease.

Conclusions

Epiphora or chemosis in the presence of an orbital mass should alert the ophthalmologist to suspect lymphoma. Lymphoma may be easily misinterpreted on neuroimaging for other diseases. Bone changes seen on CT are more common than is generally perceived. Macroscopic appearance at open biopsy was characteristic.
Literature
1.
2.
Bernardini FP, Bazzan M (2007) Lymphoproliferative disease of the orbit. Curr Opin Ophthalmol 18(5):398–401CrossRefPubMed
3.
Demirci H, Shields CL, Shields JA, Honavar SG, Mercado GJ, Tovilla JC (2002) Orbital tumors in the older adult population. Ophthalmology 109(2):243–248CrossRefPubMed
4.
Tranfa F, Di Matteo G, Strianese D, Forte R, Bonavolontà G (2001) Primary orbital lymphoma. Orbit 20(2):119–124CrossRefPubMed
5.
Kiesewetter B, Lukas J, Kuchar A et al (2014) Clinical features, treatment and outcome of mucosa-associated lymphoid tissue (MALT) lymphoma of the ocular adnexa: single center experience of 60 patients. PLoS ONE 9(7):e104004CrossRefPubMedPubMedCentral
6.
Polito E, Galieni P, Leccisotti A (1996) Clinical and radiological presentation of 95 orbital lymphoid tumors. Graefes Arch Clin Exp Ophthalmol 234(8):504–509CrossRefPubMed
7.
Cytryn AS, Putterman AM, Schneck GL, Beckman E, Valvassori GE (1997) Predictability of magnetic resonance imaging in differentiation of orbital lymphoma from orbital inflammatory syndrome. Ophthal Plast Reconstr Surg 13(2):129–134CrossRefPubMed
8.
Coupland SE, Hummel M, Stein H (2002) Ocular adnexal lymphomas: five case presentations and a review of the literature. Surv Ophthalmol 47(5):470–490CrossRefPubMed
9.
Gerbino G, Boffano P, Benech R et al (2014) Orbital lymphomas: clinical and radiological features. J Craniomaxillofac Surg 42(5):508–512CrossRefPubMed
10.
Blodi FC, Gass JDM (1968) Inflammatory pseudotumour of the orbit * t. Orbit An Int J Orbital Disord Facial Reconstr Surg 52(2):79–93
11.
Cassidy DT, McKelvie P, Harris GJ, Rose GE, McNab AA (2005) Lacrimal gland orbital lobe cysts associated with MALT lymphoma and primary Sjögren’s syndrome. Orbit 24(4):257–263CrossRefPubMed
12.
Dorey SE, Clark BJ, Christopoulos VA, Lightman S (2002) Orbital lymphoma misdiagnosed as scleritis. Ophthalmology 109(12):2347–2350CrossRefPubMed
13.
Gufler H, Gerling J, Nesbitt E, Kommerell G, Langer M (1997) MRI of lymphomas of the orbits and the paranasal sinuses. J Comput Assist Tomogr 21(6):887–891CrossRefPubMed
14.
Strianese D, Elefante A, Matarazzo F, Panico A, Ferrara M, Tranfa F (2013) Orbital lymphoma mimicking lacrimal gland pleomorphic adenoma. Case Rep Ophthalmol. 4(3):109–113CrossRefPubMedPubMedCentral
15.
Mavrikakis I, Heran MKS, Rootman J (2006) MR findings in a patient with isolated intrinsic optic nerve lymphoma. Ophthal Plast Reconstr Surg 22(6):482–484CrossRefPubMed
16.
Selva D, Rootman J, Crompton J (2004) Orbital lymphoma mimicking optic nerve meningioma. Orbit 23(2):115–120CrossRefPubMed
17.
Tovilla-Canales JL, Tovilla Y, Pomar JL, Ceron JR (2004) Lymphoproliferative disorders of the ocular adnexa. Curr Opin Ophthalmol 15(5):401–405CrossRefPubMed
18.
Kaleem Z (2006) Flow cytometric analysis of lymphomas: current status and usefulness. Arch Pathol Lab Med 130(12):1850–1858PubMed
19.
Coupland SE, Krause L, Delecluse HJ et al (1998) Lymphoproliferative lesions of the ocular adnexa: analysis of 112 cases. Ophthalmology 105(8):1430–1441CrossRefPubMed
20.
Henderson JW (1994) Hemotopoietic tumors. In: Henderson JW (ed) Orbital tumors, 3rd edn. Raven Press, New York, pp 279–307
21.
Sullivan T, Valenzuela A (2006) Imaging features of ocular adnexal lymphoproliferative disease. Eye 20(10):1189–1195CrossRefPubMed
22.
Goda JS, Gospodarowicz M, Pintilie M et al (2010) Long-term outcome in localized extranodal mucosa-associated lymphoid tissue lymphomas treated with radiotherapy. Cancer 116(16):3815–3824CrossRefPubMed
23.
Jung WS, Ahn KJ, Park MR et al (2007) The radiological spectrum of orbital pathologies that involve the lacrimal gland and the lacrimal fossa. Korean J Radiol 8(4):336–342CrossRefPubMedPubMedCentral
24.
25.
Haradome K, Haradome H, Usui Y et al (2014) Orbital lymphoproliferative disorders (OLPDs): value of MR imaging for differentiating orbital lymphoma from benign OPLDs. Am J Neuroradiol 35(10):1976–1982CrossRefPubMed
26.
Sun B, Song L, Wang X, et al. Lymphoma and inflammation in the orbit: diagnostic performance with diffusion-weighted imaging and dynamic contrast-enhanced MRI. J Magn Reson Imaging. doi:10.​1002/​jmri.​25480
27.
Flanders AE, Espinosa GA, Markiewicz DA, Howell DD (1987) Orbital lymphoma. Role of CT and MRI. Radiol Clin North Am 25(3):601–613PubMed
28.
Spielmann AC, Debelle L, Lederlin P, Antunes L, George JL (1998) Massive bone destruction: an atypical sign of orbital lymphoma. J Fr Ophtalmol 21(10):769–772PubMed
29.
Seregard S, Sahlin S (1999) Panorama of orbital space-occupying lesions. The 24-year experience of a referral centre. Acta Ophthalmol Scand 77(1):91–98CrossRefPubMed
30.
Sharara N, Holden JT, Wojno TH, Feinberg AS, Grossniklaus HE (2003) Ocular adnexal lymphoid proliferations: clinical, histologic, flow cytometric, and molecular analysis of forty-three cases. Ophthalmology 110(6):1245–1254CrossRefPubMed
31.
Gupta S, Sood B, Gulati M et al (1999) Orbital mass lesions: US-guided fine-needle aspiration biopsy–experience in 37 patients. Radiology 213(2):568–572CrossRefPubMed
32.
Ishii Y, Tomita N, Takasaki H et al (2012) Clinical features of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. Hematol Oncol 30(4):186–189CrossRefPubMed
Metadata
Title
Characteristics of orbital lymphoma: a clinicopathological study of 26 cases
Authors
Daniel Briscoe
Christine Safieh
Yokrat Ton
Hava Shapiro
Ehud I. Assia
Dvora Kidron
Publication date
01-02-2018
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 1/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0457-y

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