Top

Published in:

28-07-2023 | Biomarkers | Review

The effects of pomegranate consumption on inflammatory and oxidative stress biomarkers in adults: a systematic review and meta-analysis

Authors: Hossein Bahari, Hossein Rafiei, Kian Goudarzi, Kosar Omidian, Omid Asbaghi, Kosar Sadat Hosseini Kolbadi, Moslem Naderian, Ali Hosseini

Published in: Inflammopharmacology | Issue 5/2023

Abstract

Background

Several studies have shown the effects of pomegranate on oxidative stress and inflammation biomarkers, while some studies showed no effects of pomegranate on these biomarkers. Therefore, we aimed to evaluate the effects of pomegranate consumption on C-reactive protein (CRP), interlukin-6 (IL-6), tumor necrosis factor α (TNF-α), total antioxidant capacity (TAC), and malondialdehyde (MDA) in adults.

Methods

A systematic literature search was performed using databases, including PubMed, Web of Science, and Scopus, up to May 2023 to identify eligible randomized controlled trials (RCTs). Heterogeneity tests of the included trials were performed using the I² statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference with a 95% confidence interval.

Results

Of 3811 records, 33 eligible RCTs were included in the current study. Our meta-analysis of the pooled findings showed that pomegranate consumption significantly reduced CRP (WMD: −0.50 mg/l; 95% CI −0.79 to −0.20; p = 0.001), IL-6 (WMD: −1.24 ng/L 95% CI −1.95 to −0.54; p = 0.001), TNF-α (WMD: −1.96 pg/ml 95%CI −2.75 to −1.18; p < 0.001), and MDA (WMD: −0.34 nmol/ml 95%CI −0.42 to −0.25; p < 0.001). Pooled analysis of 13 trials revealed that pomegranate consumption led to a significant increase in TAC (WMD: 0.26 mmol/L 95%CI 0.03 to 0.49; p = 0.025).

Conclusion

Overall, the results demonstrated that pomegranate consumption has beneficial effects on oxidative stress and inflammatory biomarkers in adults. Therefore, pomegranate can be consumed as an effective dietary approach to attenuate oxidative stress and inflammation in patients with cardiovascular diseases.

PROSPERO registration code

CRD42023406684

Abedini M, Ramezani-Jolfaie N, Ghasemi-Tehrani H, Tarrahi MJ, Amani R (2023) The effect of concentrated pomegranate juice on biomarkers of inflammation, oxidative stress, and sex hormones in overweight and obese women with polycystic ovary syndrome: a randomized controlled trial. Phytother Res. https://doi.org/10.1002/ptr.7731CrossRefPubMed

Aboonabi A, Aboonabi A (2020) Anthocyanins reduce inflammation and improve glucose and lipid metabolism associated with inhibiting nuclear factor-kappaB activation and increasing PPAR-γ gene expression in metabolic syndrome subjects. Free Radical Biol Med 150:30–39CrossRef

Ağagündüz D, Cocozza E, Cemali Ö, Bayazıt AD, Nanì MF, Cerqua I, Capasso R (2023a) Understanding the role of the gut microbiome in gastrointestinal cancer: a review. Front Pharmacol 14:1130562. https://doi.org/10.3389/fphar.2023.1130562CrossRefPubMedPubMedCentral

Ağagündüz D, Icer MA, Yesildemir O, Koçak T, Kocyigit E, Capasso R (2023b) The roles of dietary lipids and lipidomics in gut-brain axis in type 2 diabetes mellitus. J Transl Med 21(1):240. https://doi.org/10.1186/s12967-023-04088-5CrossRefPubMedPubMedCentral

Ammar A, Turki M, Chtourou H, Hammouda O, Trabelsi K, Kallel C, Ayadi F (2016a) Pomegranate supplementation accelerates recovery of muscle damage and soreness and inflammatory markers after a weightlifting training session. PLoS ONE 11(10):e0160305PubMedPubMedCentralCrossRef

Ammar A, Turki M, Chtourou H, Hammouda O, Trabelsi K, Kallel C, Souissi N (2016b) Pomegranate supplementation accelerates recovery of muscle damage and soreness and inflammatory markers after a weightlifting training session. PLoS ONE. https://doi.org/10.1371/journal.pone.0160305CrossRefPubMedPubMedCentral

Ammar A, Turki M, Hammouda O, Chtourou H, Trabelsi K, Bouaziz M, Souissi N (2017a) Effects of pomegranate juice supplementation on oxidative stress biomarkers following weightlifting exercise. Nutrients 9(8):819. https://doi.org/10.3390/nu9080819CrossRefPubMedPubMedCentral

Asgary S, Sahebkar A, Afshani MR, Keshvari M, Haghjooyjavanmard S, Rafieian-Kopaei M (2014) Clinical evaluation of blood pressure lowering, endothelial function improving, hypolipidemic and anti-inflammatory effects of pomegranate juice in hypertensive subjects. Phytother Res 28(2):193–199PubMedCrossRef

Asghari G, Sheikholeslami S, Mirmiran P, Chary A, Hedayati M, Shafiee A, Azizi F (2012) Effect of pomegranate seed oil on serum TNF-α level in dyslipidemic patients. Int J Food Sci Nutr 63(3):368–371PubMedCrossRef

Augustin W, Wiswedel I, Noack H, Reinheckel T, Reichelt O (1997) Role of endogenous and exogenous antioxidants in the defence against functional damage and lipid peroxidation in rat liver mitochondria. Detection of mitochondrial diseases. Springer, US, Boston, pp 199–205CrossRef

Aviram M, Dornfeld L, Rosenblat M, Volkova N, Kaplan M, Coleman R, Fuhrman B (2000) Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E–deficient mice. Am J Clin Nutr 71(5):1062–1076PubMedCrossRef

Babaeian S, Ebrahimi-Mameghani M, Niafar M, Sanaii S (2013) The effect of unsweetened pomegranate juice on insulin resistance, high sensitivity c-reactive protein and obesity among type 2 diabetes patients. J Ardabil Univ Med Sci 13(1):7–15

Banerjee N, Kim H, Talcott S, Mertens-Talcott S (2013) Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR. Carcinogenesis 34(12):2814–2822. https://doi.org/10.1093/carcin/bgt295CrossRefPubMed

Barati Boldaji R, Akhlaghi M, Sagheb MM, Esmaeilinezhad Z (2020) Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial. J Sci Food Agric 100(2):846–854PubMedCrossRef

Bayat-Chadegani E, Fallahzadeh H, Askari G, Rahavi R, Maghsoudi Z, Nadjarzadeh A (2015) The effect of pomegranate juice supplementation on muscle damage, oxidative stress and inflammation induced by exercise in healthy young men. J Isfahan Med School 32(320):2464–2472

Behl T, Upadhyay T, Singh S, Chigurupati S, Alsubayiel AM, Mani V, Bungau SG (2021) Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis. Molecules. https://doi.org/10.3390/molecules26216570CrossRefPubMedPubMedCentral

Behl T, Rana T, Alotaibi GH, Shamsuzzaman M, Naqvi M, Sehgal A, Bungau S (2022) Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression. Biomed Pharmacother 146:112545. https://doi.org/10.1016/j.biopha.2021.112545CrossRefPubMed

Bondia-Pons I, Ryan L, Martinez JA (2012) Oxidative stress and inflammation interactions in human obesity. J Physiol Biochem 68:701–711PubMedCrossRef

Borenstein M, Hedges LV, Higgins JP, Rothstein HR (2021) Introduction to meta-analysis. John Wiley and Sons, HobokenCrossRef

Castañeda S, Nurmohamed MT, González-Gay MA (2016) Cardiovascular disease in inflammatory rheumatic diseases. Best Pract Res Clin Rheumatol 30(5):851–869PubMedCrossRef

Clerkin J, Naughton R, Quiney C, Cotter T (2008) Mechanisms of ROS modulated cell survival during carcinogenesis. Cancer Lett 266(1):30–36PubMedCrossRef

Cremonini E, Daveri E, Iglesias DE, Kang J, Wang Z, Gray R, Wood SM (2022) A randomized placebo-controlled cross-over study on the effects of anthocyanins on inflammatory and metabolic responses to a high-fat meal in healthy subjects. Redox Biol 51:102273PubMedPubMedCentralCrossRef

Davidson MH, Maki KC, Dicklin MR, Feinstein SB, Witchger M, Bell M, Aviram M (2009) Effects of consumption of pomegranate juice on carotid intima–media thickness in men and women at moderate risk for coronary heart disease. Am J Cardiol 104(7):936–942PubMedCrossRef

Davinelli S, Bertoglio JC, Zarrelli A, Pina R, Scapagnini G (2015) A randomized clinical trial evaluating the efficacy of an anthocyanin–maqui berry extract (Delphinol®) on oxidative stress biomarkers. J Am Coll Nutr 34(sup1):28–33PubMedCrossRef

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188PubMedCrossRef

Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634PubMedPubMedCentralCrossRef

Epingeac ME, Gaman MA, Diaconu CC, Gaman AM (2020) Crosstalk between oxidative stress and inflammation in obesity. Inflammation 10:18

Esmaeilinezhad Z, Barati-Boldaji R, Brett N, De Zepetnek J, Bellissimo N, Babajafari S, Sohrabi Z (2020) The effect of synbiotics pomegranate juice on cardiovascular risk factors in PCOS patients: a randomized, triple-blinded, controlled trial. J Endocrinol Invest 43:539–548PubMedCrossRef

Faria A, Monteiro R, Mateus N, Azevedo I, Calhau C (2007) Effect of pomegranate (Punica granatum) juice intake on hepatic oxidative stress. Eur J Nutr 46:271–278PubMedCrossRef

Fernández J, Silván B, Entrialgo-Cadierno R, Villar CJ, Capasso R, Uranga JA, Abalo R (2021) Antiproliferative and palliative activity of flavonoids in colorectal cancer. Biomed Pharmacother 143:112241. https://doi.org/10.1016/j.biopha.2021.112241CrossRefPubMed

Ferrarini EG, Paes RS, Baldasso GM, de Assis PM, Gouvêa MC, Cicco P, Dutra RC (2022) Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice. Biomed Pharmacother 154:113552. https://doi.org/10.1016/j.biopha.2022.113552CrossRefPubMed

Fischer R, Maier O (2015) Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF. Oxid Med Cell Longev. https://doi.org/10.1155/2015/610813CrossRefPubMedPubMedCentral

Freitas MA, Vasconcelos A, Gonçalves ECD, Ferrarini EG, Vieira GB, Cicia D, Dutra RC (2021) Involvement of opioid system and TRPM8/TRPA1 channels in the antinociceptive effect of spirulina platensis. Biomolecules. https://doi.org/10.3390/biom11040592CrossRefPubMedPubMedCentral

Ghavipour M, Sotoudeh G, Tavakoli E, Mowla K, Hasanzadeh J, Mazloom Z (2017) Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in Rheumatoid Arthritis patients. Eur J Clin Nutr 71(1):92–96PubMedCrossRef

González R, Ballester I, López-Posadas R, Suárez M, Zarzuelo A, Martínez-Augustin O, Medina FSD (2011) Effects of flavonoids and other polyphenols on inflammation. Crit Rev Food Sci Nutr 51(4):331–362PubMedCrossRef

Grabež M, Škrbić R, Stojiljković MP, Vučić VM, Grujić VR, Jakovljević V, Bigović D (2022) A prospective, randomized, double-blind, placebo-controlled trial of polyphenols on the outcomes of inflammatory factors and oxidative stress in patients with type 2 diabetes mellitus. Rev Cardiovasc Med 23(2):57PubMedCrossRef

Haghighian MK, Rafraf M, Moghaddam A, Hemmati S, Jafarabadi MA, Gargari BP (2016) Pomegranate (Punica granatum L.) peel hydro alcoholic extract ameliorates cardiovascular risk factors in obese women with dyslipidemia: a double blind, randomized, placebo controlled pilot study. Eur J Integr Med 8(5):676–682CrossRef

Haghighian MK, Rafraf M, Hemmati S, Haghravan S, Asghari-Jafarabadi M (2021) Effects of pomegranate (Punica granatum L.) peel extract supplementation on serum lipid profile and oxidative stress in obese women with knee osteoarthritis: a double blind, randomized, placebo controlled study. Adv Integr Med 8(2):107–113CrossRef

Hamoud S, Hayek T, Volkova N, Attias J, Moscoviz D, Rosenblat M, Aviram M (2014) Pomegranate extract (POMx) decreases the atherogenicity of serum and of human monocyte-derived macrophages (HMDM) in simvastatin-treated hypercholesterolemic patients: a double-blinded, placebo-controlled, randomized, prospective pilot study. Atherosclerosis 232(1):204–210PubMedCrossRef

Harris IS, DeNicola GM (2020) The complex interplay between antioxidants and ROS in cancer. Trends Cell Biol 30(6):440–451PubMedCrossRef

Heim KE, Tagliaferro AR, Bobilya DJ (2002) Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem 13(10):572–584PubMedCrossRef

Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558. https://doi.org/10.1002/sim.1186CrossRefPubMed

Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560. https://doi.org/10.1136/bmj.327.7414.557CrossRefPubMedPubMedCentral

Higgins J, Green S (2010) Cochrane handbook for systematic reviews of interventions, version 5.0. 2 [updated Sept 2009], The Cochrane Collaboration, 2009. In

Hosseini B, Saedisomeolia A, Wood LG, Yaseri M, Tavasoli S (2016) Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: a randomized controlled clinical trial. Complement Ther Clin Pract 22:44–50PubMedCrossRef

Hozo SP, Djulbegovic B, Hozo I (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 5:13. https://doi.org/10.1186/1471-2288-5-13CrossRefPubMedPubMedCentral

Huguet A, Hayden JA, Stinson J, McGrath PJ, Chambers CT, Tougas ME, Wozney L (2013) Judging the quality of evidence in reviews of prognostic factor research: adapting the GRADE framework. Syst Rev 2(1):71. https://doi.org/10.1186/2046-4053-2-71CrossRefPubMedPubMedCentral

Hussain T, Tan B, Yin Y, Blachier F, Tossou MC, Rahu N (2016) Oxidative stress and inflammation: what polyphenols can do for us? Oxid Med Cell Longev. https://doi.org/10.1155/2016/7432797CrossRefPubMedPubMedCentral

Jafari T, Fallah AA, Bahrami M, Lorigooini Z (2020a) Effects of pomegranate peel extract and vitamin E on oxidative stress and antioxidative capacity of hemodialysis patients: a randomized controlled clinical trial. J Funct Foods 72:104069. https://doi.org/10.1016/j.jff.2020.104069CrossRef

Jafari T, Fallah AA, Reyhanian A, Sarmast E (2020b) Effects of pomegranate peel extract and vitamin E on the inflammatory status and endothelial function in hemodialysis patients: a randomized controlled clinical trial. Food Funct 11(9):7987–7993PubMedCrossRef

Jafarirad S, Goodarzi R, Mohammadtaghvaei N, Dastoorpoor M, Alavinejad P (2023) Effectiveness of the pomegranate extract in improving hepatokines and serum biomarkers of non-alcoholic fatty liver disease: a randomized double blind clinical trial. Diabetes Metab Syndr 17(1):102693. https://doi.org/10.1016/j.dsx.2022.102693CrossRefPubMed

Khajebishak Y, Payahoo L, Hamishehkar H, Alivand M, Alipour M, Solhi M, Alipour B (2019) Effect of pomegranate seed oil on the expression of PPAR-γ and pro-inflammatory biomarkers in obese type 2 diabetic patients. Nutr Food Sci 49(5):854–865

Lee Y-H, Pratley RE (2005) The evolving role of inflammation in obesity and the metabolic syndrome. Curr DiabRep 5(1):70–75

Lee S, Park Y, Zuidema MY, Hannink M, Zhang C (2011) Effects of interventions on oxidative stress and inflammation of cardiovascular diseases. World J Cardiol 3(1):18PubMedPubMedCentralCrossRef

Lorzadeh E, Heidary Z, Mohammadi M, Nadjarzadeh A, Ramezani-Jolfaie N, Salehi-Abargouei A (2022) Does pomegranate consumption improve oxidative stress? A systematic review and meta-analysis of randomized controlled clinical trials. Clin Nutr ESPEN 47:117–127PubMedCrossRef

Mazani M, Fard A, Baghi A, Nemati A, Mogadam R (2014) Effect of pomegranate juice supplementation on matrix metalloproteinases 2 and 9 following exhaustive exercise in young healthy males. J Pak Med Assoc 64:785–790PubMed

Moazzen H, Alizadeh M (2017) Effects of pomegranate juice on cardiovascular risk factors in patients with metabolic syndrome: a double-blinded, randomized crossover controlled trial. Plant Foods Hum Nutr 72:126–133PubMedCrossRef

Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151(4):264–269PubMedCrossRef

Monteiro R, Azevedo I (2010) Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm. https://doi.org/10.1155/2010/289645CrossRefPubMedPubMedCentral

Morvaridzadeh M, Sepidarkish M, Daneshzad E, Akbari A, Mobini GR, Heshmati J (2020) The effect of pomegranate on oxidative stress parameters: a systematic review and meta-analysis. Complement Ther Med 48:102252PubMedCrossRef

Naghizadeh-Baghi A, Mazani M, Shadman-Fard A, Nemati A (2015) Punica granatum juice effects on oxidative stress in severe physical activity. Mater Socio-Medica 27(1):48CrossRef

Omidian K, Rafiei H, Bandy B (2017) Polyphenol inhibition of benzo [a] pyrene-induced oxidative stress and neoplastic transformation in an in vitro model of carcinogenesis. Food Chem Toxicol 106:165–174PubMedCrossRef

O’Rourke RW (2009) Inflammation in obesity-related diseases. Surgery 145(3):255–259PubMedCrossRef

Pieczenik SR, Neustadt J (2007) Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol 83(1):84–92PubMedCrossRef

Rafiei H, Omidian K, Bandy B (2019) Phenolic breakdown products of cyanidin and quercetin contribute to protection against mitochondrial impairment and reactive oxygen species generation in an in vitro model of hepatocyte steatosis. J Agric Food Chem 67(22):6241–6247PubMedCrossRef

Rahman I, Biswas SK, Kirkham PA (2006) Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 72(11):1439–1452PubMedCrossRef

Rouzbehan B, Abed Natanzi H, Ebrahim K, Ghazalian F (2021) The effect of aerobic exercise and pomegranate juice consumption on serum enzyme levels associated with the oxidant-antioxidant system of women rescued from breast cancer. Iran J Obstet Gynecol Infertil 24(6):25–35. https://doi.org/10.22038/ijogi.2021.18735CrossRef

Santangelo C, Varì R, Scazzocchio B, Di Benedetto R, Filesi C, Masella R (2007) Polyphenols, intracellular signalling and inflammation. Annali-Istituto Superiore Di Sanita 43(4):394

Shabbir U, Tyagi A, Elahi F, Aloo SO, Oh D-H (2021) The potential role of polyphenols in oxidative stress and inflammation induced by gut microbiota in alzheimer’s disease. Antioxidants 10(9):1370PubMedPubMedCentralCrossRef

Shateri Z, Hosseini SA, Abolnezhadian F, Maraghi E, Haddadzadeh Shoushtari M, Zilaee M (2022) Pomegranate extract supplementation improves lung function parameters and IL-35 expression in participants with mild and moderate persistent allergic asthma: A randomized, double-blind, placebo-controlled trial. Front Nutr. https://doi.org/10.3389/fnut.2022.1026343CrossRefPubMedPubMedCentral

Shema-Didi L, Sela S, Ore L, Shapiro G, Geron R, Moshe G, Kristal B (2012) One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: a randomized placebo-controlled trial. Free Radical Biol Med 53(2):297–304CrossRef

Shih P-H, Yeh C-T, Yen G-C (2007) Anthocyanins induce the activation of phase II enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis. J Agric Food Chem 55(23):9427–9435PubMedCrossRef

Sohrab G, Nasrollahzadeh J, Zand H, Amiri Z, Tohidi M, Kimiagar M (2014) Effects of pomegranate juice consumption on inflammatory markers in patients with type 2 diabetes: a randomized, placebo-controlled trial. J Res Med Sci 19(3):215PubMedPubMedCentral

Sohrab G, Angoorani P, Tohidi M, Tabibi H, Kimiagar M, Nasrollahzadeh J (2015) Pomegranate (Punicagranatum) juice decreases lipid peroxidation, but has no effect on plasma advanced glycated end-products in adults with type 2 diabetes: a randomized double-blind clinical trial. Food Nutr Res 59(1):28551PubMedCrossRef

Sohrab G, Ebrahimof S, Sotoudeh G, Neyestani TR, Angoorani P, Hedayati M, Siasi F (2017) Effects of pomegranate juice consumption on oxidative stress in patients with type 2 diabetes: a single-blind, randomized clinical trial. Int J Food Sci Nutr 68(2):249–255PubMedCrossRef

Stockton A, Farhat G, McDougall GJ, Al-Dujaili ES (2017) Effect of pomegranate extract on blood pressure and anthropometry in adults: a double-blind placebo-controlled randomised clinical trial. J Nutr Sci 6:e39PubMedCrossRef

Tobias A (1999) Assessing the influence of a single study in the meta-analysis estimate. Stata Tech Bull 47:15–17

Torre E (2017) Molecular signaling mechanisms behind polyphenol-induced bone anabolism. Phytochem Rev 16(6):1183–1226. https://doi.org/10.1007/s11101-017-9529-xCrossRefPubMedPubMedCentral

Tsuda T, Horio F, Osawa T (2000) The role of anthocyanins as an antioxidant under oxidative stress in rats. BioFactors 13(1–4):133–139PubMedCrossRef

Urbaniak A, Basta P, Ast K, Wołoszyn A, Kuriańska-Wołoszyn J, Latour E, Skarpańska-Stejnborn A (2018) The impact of supplementation with pomegranate fruit (Punica granatum L.) juice on selected antioxidant parameters and markers of iron metabolism in rowers. J Int Soc Sports Nutr 15(1):35PubMedPubMedCentralCrossRef

Voeikov VL (2006) Reactive oxygen species—(ROS) pathogens or sources of vital energy? Part 1 ROS in normal and pathologic physiology of living systems. J Altern Complement Med 12(2):111–118PubMedCrossRef

Wu P-T, Fitschen PJ, Kistler BM, Jeong JH, Chung HR, Aviram M, Wilund KR (2015) Effects of pomegranate extract supplementation on cardiovascular risk factors and physical function in hemodialysis patients. J Med Food 18(9):941–949PubMedCrossRef

Yarmohammadi M, Mahjoub S (2017) Effects of aerobic exercise and pomegranate extract on antioxidant markers in women postmenopausal with type 2 diabetes. Hormo Med J 21(2)

Zarezadeh M, Saedisomeolia A, Hosseini B, Emami MR (2019) The effect of Punica granatum (pomegranate) extract on inflammatory biomarkers, lipid profile, and glycemic indices in patients with overweight and obesity: randomized clinical trial. Qom Univ Med Sci J 13:14–25CrossRef

Zhang H, Tsao R (2016) Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Curr Opin Food Sci 8:33–42CrossRef

Zhao X, Yuan Z (2021) Anthocyanins from pomegranate (Punica granatum L.) and their role in antioxidant capacities in vitro. Chem Biodivers 18(10):e2100399PubMedCrossRef

Title: The effects of pomegranate consumption on inflammatory and oxidative stress biomarkers in adults: a systematic review and meta-analysis
Authors: Hossein Bahari
Hossein Rafiei
Kian Goudarzi
Kosar Omidian
Omid Asbaghi
Kosar Sadat Hosseini Kolbadi
Moslem Naderian
Ali Hosseini
Publication date: 28-07-2023
Publisher: Springer International Publishing
Keyword: Biomarkers
Published in: Inflammopharmacology / Issue 5/2023
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-023-01294-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The effects of pomegranate consumption on inflammatory and oxidative stress biomarkers in adults: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusion

PROSPERO registration code

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

PROSPERO registration code

Please log in to get access to this content

Other articles of this Issue 5/2023

The effect of risperidone on behavioral reactions and gene expression of pro- and anti-inflammatory cytokines in neuropathic pain model induced by chronic constriction injury of the sciatic nerve in rat

Clinical efficacy and safety of melatonin supplementation in multiple sclerosis: a systematic review

A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: a randomized, double-blinded, placebo-controlled clinical trial

Potential of bone morphogenetic protein-7 in treatment of lupus nephritis: addressing the hurdles to implementation

The orchestrating role of deteriorating neurons and TREM-1 in crosstalk with SYK in Alzheimer’s disease progression and neuroinflammation

Zinc and L-carnitine combination with or without methotrexate prevents intestinal toxicity during arthritis treatment via Nrf2/Sirt1/Foxo3 pathways: an In vivo and molecular docking approach