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01-10-2020 | Methotrexate | Review

The advances of methotrexate resistance in rheumatoid arthritis

Authors: Jun Yu, Peng Zhou

Published in: Inflammopharmacology | Issue 5/2020

Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease, which is characterized by a chronic fluctuating course and immune dysfunction, resulting in affecting the health and life quality of RA patients. Methotrexate (MTX), as the standard gold treatment of RA, has received more and more clinical applications and basic pharmacological research. In several observational studies, MTXR, and treatment responses in RA patients show that the ratio of MTXR and non- response is about 30%–50%, namely MTX resistance (MTXR). Extensive efforts have been made into the investigation of the mechanism and effective biomarkers in MTXR of RA. In this paper, we discuss the recent findings regarding the critical signaling pathways of MTXR in RA. Provide research targets and directions for a drug therapy that develop preventive strategies and effective treatments of MTXR.

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Title: The advances of methotrexate resistance in rheumatoid arthritis
Authors: Jun Yu
Peng Zhou
Publication date: 01-10-2020
Publisher: Springer International Publishing
Keywords: Methotrexate
Methotrexate
Rheumatoid Arthritis
Published in: Inflammopharmacology / Issue 5/2020
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-020-00741-3

At a glance: The STEP trials

Springer Medicine

The advances of methotrexate resistance in rheumatoid arthritis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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